Amide proton transfer imaging in stroke

Heo, Hye Young; Tee, Yee Kai; Harston, George; Leigh, Richard; Chappell, Michael A.

Abstract

Amide proton transfer (APT) imaging, a variant of chemical exchange saturation transfer MRI, has shown promise in detecting ischemic tissue acidosis following impaired aerobic metabolism in animal models and in human stroke patients due to the sensitivity of the amide proton exchange rate to changes in pH within the physiological range. Recent studies have demonstrated the possibility of using APT-MRI to detect acidosis of the ischemic penumbra, enabling the assessment of stroke severity and risk of progression, monitoring of treatment progress, and prognostication of clinical outcome. This paper reviews current APT imaging methods actively used in ischemic stroke research and explores the clinical aspects of ischemic stroke and future applications for these methods.

Citation

Heo, H. Y., Tee, Y. K., Harston, G., Leigh, R., & Chappell, M. A. (2022). Amide proton transfer imaging in stroke. NMR in Biomedicine, Article e4734. https://doi.org/10.1002/nbm.4734

• Journal Article Type: Article
• Acceptance Date: Mar 21, 2022
• Online Publication Date: Apr 10, 2022
• Publication Date: Apr 10, 2022
• Deposit Date: Apr 11, 2022
• Publicly Available Date: Apr 12, 2022
• Journal: NMR in Biomedicine
• Print ISSN: 0952-3480
• Electronic ISSN: 1099-1492
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Article Number: e4734
• DOI: https://doi.org/10.1002/nbm.4734
• Keywords: Spectroscopy; Radiology, Nuclear Medicine and imaging; Molecular Medicine
• Public URL: https://nottingham-repository.worktribe.com/output/7755062
• Publisher URL: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/nbm.4734