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Amide proton transfer imaging in stroke

Heo, Hye Young; Tee, Yee Kai; Harston, George; Leigh, Richard; Chappell, Michael A.

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Hye Young Heo

Yee Kai Tee

George Harston

Richard Leigh


Amide proton transfer (APT) imaging, a variant of chemical exchange saturation transfer MRI, has shown promise in detecting ischemic tissue acidosis following impaired aerobic metabolism in animal models and in human stroke patients due to the sensitivity of the amide proton exchange rate to changes in pH within the physiological range. Recent studies have demonstrated the possibility of using APT-MRI to detect acidosis of the ischemic penumbra, enabling the assessment of stroke severity and risk of progression, monitoring of treatment progress, and prognostication of clinical outcome. This paper reviews current APT imaging methods actively used in ischemic stroke research and explores the clinical aspects of ischemic stroke and future applications for these methods.

Journal Article Type Article
Acceptance Date Mar 21, 2022
Online Publication Date Apr 10, 2022
Publication Date Apr 10, 2022
Deposit Date Apr 11, 2022
Publicly Available Date Apr 12, 2022
Journal NMR in Biomedicine
Print ISSN 0952-3480
Electronic ISSN 1099-1492
Publisher Wiley
Peer Reviewed Peer Reviewed
Article Number e4734
Keywords Spectroscopy; Radiology, Nuclear Medicine and imaging; Molecular Medicine
Public URL
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