All Outputs (60)

Controlling the release of indomethacin from glass solutions layered with a rate controlling membrane using fluid-bed processing. Part 1: Surface and cross-sectional chemical analysis (2017)
Journal Article

Fluid bed coating has been shown to be a suitable manufacturing technique to formulate poorly soluble drugs in glass solutions. Layering inert carriers with a drug–polymer mixture enables these beads to be immediately filled into capsules, thus avoid... Read More about Controlling the release of indomethacin from glass solutions layered with a rate controlling membrane using fluid-bed processing. Part 1: Surface and cross-sectional chemical analysis.

Quantification and qualitative effects of different PEGylations on Poly(butyl cyanoacrylate) nanoparticles (2017)
Journal Article

Protein adsorption on nanoparticles (NPs) used in nanomedicine leads to opsonization and activation of the complement system in blood, which substantially reduces the blood circulation time of NPs. The most commonly used method to avoid protein adsor... Read More about Quantification and qualitative effects of different PEGylations on Poly(butyl cyanoacrylate) nanoparticles.

Surface modification of PdlLGA microspheres with gelatine methacrylate: evaluation of adsorption, entrapment, and oxygen plasma treatment approaches (2017)
Journal Article

Injectable poly (dl-lactic-co-glycolic acid) (PdlLGA) microspheres are promising candidates as biodegradable controlled release carriers for drug and cell delivery applications; however, they have limited functional groups on the surface to enable de... Read More about Surface modification of PdlLGA microspheres with gelatine methacrylate: evaluation of adsorption, entrapment, and oxygen plasma treatment approaches.

Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly (2016)
Journal Article

Molecular self-assembly of peptides into ordered nanotubes is highly important for various technological applications. Very short peptide building blocks, as short as dipeptides, can form assemblies with unique mechanical, optical, piezoelectric, and... Read More about Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly.

Age-related changes to human stratum corneum lipids detected using time-of-flight secondary ion mass spectrometry following in vivo sampling (2016)
Journal Article

This work demonstrates the ability to detect changes in both quantity and spatial distribution of human stratum corneum (SC) lipids from samples collected in vivo. The SC functions as the predominant barrier to the body, protecting against the penetr... Read More about Age-related changes to human stratum corneum lipids detected using time-of-flight secondary ion mass spectrometry following in vivo sampling.

Imaging of Crystalline and Amorphous Surface Regions Using Time-of-Flight Secondary-Ion Mass Spectrometry (ToF-SIMS): Application to Pharmaceutical Materials (2016)
Journal Article

The structure of a material, in particular the extremes of crystalline and amorphous forms, significantly impacts material performance in numerous sectors such as semiconductors, energy storage, and pharmaceutical products, which are investigated in... Read More about Imaging of Crystalline and Amorphous Surface Regions Using Time-of-Flight Secondary-Ion Mass Spectrometry (ToF-SIMS): Application to Pharmaceutical Materials.

Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks (2015)
Journal Article

Advanced data analysis tools are crucial for the application of ToF-SIMS analysis to biological samples. Here, we demonstrate that by using a training set approach principal components analysis (PCA) can be performed on large 3D ToF-SIMS images of ne... Read More about Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks.

3D chemical characterization of frozen hydrated hydrogels using ToF-SIMS with argon cluster sputter depth profiling (2015)
Journal Article

Hydrogels have been used extensively in bioengineering as artificial cell culture supports. Investigation of the interrelationship between cellular response to the hydrogel and its chemistry ideally requires methods that allow characterization withou... Read More about 3D chemical characterization of frozen hydrated hydrogels using ToF-SIMS with argon cluster sputter depth profiling.

Multivariate ToF-SIMS image analysis of polymer microarrays and protein adsorption (2015)
Journal Article

The complexity of hyperspectral time of flight secondary ion mass spectrometry (ToF-SIMS) datasets makes their subsequent analysis and interpretation challenging, and is often an impasse to the identification of trends and differences within large sa... Read More about Multivariate ToF-SIMS image analysis of polymer microarrays and protein adsorption.

The Influence of Spray-Drying Parameters on Phase Behavior, Drug Distribution, and In Vitro Release of Injectable Microspheres for Sustained Release (2015)
Journal Article

Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity (2015)
Journal Article

© 2015 Published by Elsevier B.V. Catheter-associated urinary tract infection (CAUTI) is the commonest hospital-acquired infection, accounting for over 100,000 hospital admissions within the USA annually. Biomaterials and processes intended to reduce... Read More about Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity.

3D ToF-SIMS Imaging of Polymer Multilayer Films Using Argon Cluster Sputter Depth Profiling (2015)
Journal Article

ToF-SIMS imaging with argon cluster sputter depth profiling has provided detailed insight into the three-dimensional (3D) chemical composition of a series of polymer multilayer structures. Depths of more than 15 μm were profiled in these samples whil... Read More about 3D ToF-SIMS Imaging of Polymer Multilayer Films Using Argon Cluster Sputter Depth Profiling.

In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor (2014)
Journal Article

At present no scientific rationale exists for selecting a particular enabling strategy to formulate a poorly water-soluble drug, although this is crucial as it will influence the in vivo performance of the resulting formulation. This study provides a... Read More about In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor.

Combination of (M)DSC and Surface Analysis to Study the Phase Behaviour and Drug Distribution of Ternary Solid Dispersions (2014)
Journal Article

Purpose: Miscibility of the different compounds that make up a solid dispersion based formulation play a crucial role in the drug release profile and physical stability of the solid dispersion as it defines the phase behaviour of the dispersion. The... Read More about Combination of (M)DSC and Surface Analysis to Study the Phase Behaviour and Drug Distribution of Ternary Solid Dispersions.

Spectroscopic Studies of Internal Injector Deposits (IDID) Resulting from the Use of Non-Commercial Low Molecular Weight Polyisobutylenesuccinimide (PIBSI) (2014)
Journal Article

Copyright © 2014 SAE International. Since 2009, there has been a rise in deposits of various types found in diesel fuel injection systems. They have been identified in the filter, the injector tip and recently inside the injector. The latter internal... Read More about Spectroscopic Studies of Internal Injector Deposits (IDID) Resulting from the Use of Non-Commercial Low Molecular Weight Polyisobutylenesuccinimide (PIBSI).

Injectable and porous PLGA microspheres that form highly porous scaffolds at body temperature (2014)
Journal Article

Injectable scaffolds are of interest in the field of regenerative medicine because of their minimally invasive mode of delivery. For tissue repair applications, it is essential that such scaffolds have the mechanical properties, porosity and pore dia... Read More about Injectable and porous PLGA microspheres that form highly porous scaffolds at body temperature.

High throughput screening for biomaterials discovery (2014)
Journal Article

Using microarray technologies thousands of biomedical materials can be screened in a rapid, parallel and cost effective fashion to identify the optimum candidate that fulfils a specific biomedical application. High throughput surface characterization... Read More about High throughput screening for biomaterials discovery.

Thermally Switchable Polymers Achieve Controlled Escherichia coli Detachment (2014)
Journal Article

The thermally triggered release of up to 96% of attached uropathogenic E. coli is achieved on two polymers with opposite changes in surface wettability upon reduction in temperature. This demonstrates that the bacterial attachment to a surface cannot... Read More about Thermally Switchable Polymers Achieve Controlled Escherichia coli Detachment.

Ambient DESI and LESA-MS analysis of proteins adsorbed to a biomaterial surface using in-situ surface tryptic digestion (2013)
Journal Article

The detection and identification of proteins adsorbed onto biomaterial surfaces under ambient conditions has significant experimental advantages but has proven to be difficult to achieve with conventional measuring technologies. In this study, we pre... Read More about Ambient DESI and LESA-MS analysis of proteins adsorbed to a biomaterial surface using in-situ surface tryptic digestion.

Strategies for MCR image analysis of large hyperspectral data-sets (2012)
Journal Article

Polymer microarrays are a key enabling technology for high throughput materials discovery. In this study, multivariate image analysis, specifically multivariate curve resolution (MCR), is applied to the hyperspectral time of flight secondary ion mass... Read More about Strategies for MCR image analysis of large hyperspectral data-sets.