Skip to main content

Research Repository

Advanced Search

Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity

Fisher, Leanne E.; Hook, Andrew L.; Ashraf, Waheed; Yousef, Anfal; Barrett, David A.; Scurr, David J.; Chen, Xinyong; Smith, Emily F.; Fay, Michael; Parmenter, Christopher D.J.; Parkinson, Richard; Bayston, Roger

Authors

ANDREW HOOK ANDREW.HOOK@NOTTINGHAM.AC.UK
Nottingham Research Fellow

Waheed Ashraf

Anfal Yousef

David A. Barrett

DAVID SCURR david.scurr@nottingham.ac.uk
Senior Research Fellow in Surface Analysis

Xinyong Chen

Emily F. Smith

Richard Parkinson



Abstract

Catheter-associated urinary tract infection (CAUTI) is the commonest hospital-acquired infection, accounting for over 100,000 hospital admissions within the USA annually. Biomaterials and processes intended to reduce the risk of bacterial colonization of the catheters for long-term users have not been successful, mainly because of the need for long duration of activity in flow conditions. Here we report the results of impregnation of urinary catheters with a combination of rifampicin, sparfloxacin and triclosan. In flow experiments, the antimicrobial catheters were able to prevent colonization by common uropathogens Proteus mirabilis, Staphylococcus aureus and Escherichia coli for 7 to 12 weeks in vitro compared with 1–3 days for other, commercially available antimicrobial catheters currently used clinically. Resistance development was minimized by careful choice of antimicrobial combinations. Drug release profiles and distribution in the polymer, and surface analysis were also carried out and the process had no deleterious effect on the mechanical performance of the catheter or its balloon. The antimicrobial catheter therefore offers for the first time a means of reducing infection and its complications in long-term urinary catheter users.

Citation

Fisher, L. E., Hook, A. L., Ashraf, W., Yousef, A., Barrett, D. A., Scurr, D. J., …Bayston, R. (2015). Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity. Journal of Controlled Release, 202, 57-64. https://doi.org/10.1016/j.jconrel.2015.01.037

Journal Article Type Article
Acceptance Date Jan 28, 2015
Online Publication Date Jan 30, 2015
Publication Date Mar 28, 2015
Deposit Date Aug 22, 2017
Publicly Available Date Aug 22, 2017
Journal Journal of Controlled Release
Print ISSN 0168-3659
Electronic ISSN 1873-4995
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 202
Pages 57-64
DOI https://doi.org/10.1016/j.jconrel.2015.01.037
Keywords Antimicrobial; Bladder; Catheter infection; Drug release; Silicone; Urinary tract
Public URL http://eprints.nottingham.ac.uk/id/eprint/45041
Publisher URL http://www.sciencedirect.com/science/article/pii/S0168365915000875?via%3Dihub
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0
Additional Information This article is maintained by: Elsevier; Article Title: Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity; Journal Title: Journal of Controlled Release; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jconrel.2015.01.037; Content Type: article; Copyright: Copyright © 2015 The Authors. Published by Elsevier B.V.

Files

1-s2.0-S0168365915000875-main.pdf (2.1 Mb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





You might also like



Downloadable Citations