Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis

Barr, Helen L.; Halliday, Nigel; C�mara, Miguel; Barrett, David A.; Williams, Paul; Forrester, Douglas L.; Simms, Rebecca; Smyth, Alan R.; Honeybourne, David; Whitehouse, Joanna L.; Nash, Edward F.; Dewar, Jane; Clayton, Andrew; Knox, Alan J.; Fogarty, Andrew W.

doi:10.1183/09031936.00225214

Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial: Oral Glutamine Supplementation in Cystic Fibrosis (2015)
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Rationale: Pulmonary infection and malnutrition in cystic fibrosis are associated with decreased survival. Glutamine has a possible anti-microbial effect, with a specific impact against Pseudomonas aeruginosa. We aimed to test the hypothesis that ora... Read More about Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial: Oral Glutamine Supplementation in Cystic Fibrosis.

In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011 (2015)
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Banning of fetal sex determination and changes in sex ratio in India (2015)
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Effect of early and current Helicobacter pylori infection on the risk of anaemia in 6.5-year-old Ethiopian children (2015)
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Background Epidemiological and clinical studies in high income countries have suggested that Helicobacter pylori (H. pylori) may cause anaemia, but evidence is lacking from low income countries.We examined associations between H. pylori infection... Read More about Effect of early and current Helicobacter pylori infection on the risk of anaemia in 6.5-year-old Ethiopian children.

Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients (2015)
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There is a clinical need for reliable biomarkers for lung cancer that permit early diagnosis of the disease and provide prediction of histological phenotype. A prospective study design was used with a study population of patients with suspected lung... Read More about Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients.

Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review (2015)
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Introduction: As idiopathic pulmonary fibrosis emerges as an important public health problem, there is a need to coordinate data on incidence and mortality globally. This study aims to systematically assess all available studies to investigate the gl... Read More about Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review.

Complications and mortality in hereditary hemorrhagic telangiectasia: a population-based study (2015)
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OBJECTIVES: Studies report that the risks of significant neurologic complications (including stroke, cerebral abscess, and migraine) and hemorrhagic sequelae are high in patients with hereditary hemorrhagic telangiectasia (HHT), and that life expe... Read More about Complications and mortality in hereditary hemorrhagic telangiectasia: a population-based study.

Granulocyte-macrophage colony stimulatory factor enhances the pro-inflammatory response of interferon-?-treated macrophages to pseudomonas aeruginosa infection (2015)
Journal Article

Pseudomonas aeruginosa is an opportunistic pathogen that can cause severe infections at compromised epithelial surfaces, such those found in burns, wounds, and in lungs damaged by mechanical ventilation or recurrent infections, particularly in cystic... Read More about Granulocyte-macrophage colony stimulatory factor enhances the pro-inflammatory response of interferon-?-treated macrophages to pseudomonas aeruginosa infection.

Association of socioeconomic status with sex ratio at live birth in individuals living in the slums of Sholapur city, India (2015)
Journal Article

Background: The existence of female feticide in India is well known. However, limited data are available on the association of socioeconomic status (SES) on sex ratio at live birth in disadvantaged populations, despite the fact that 33% of the popula... Read More about Association of socioeconomic status with sex ratio at live birth in individuals living in the slums of Sholapur city, India.

Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection (2015)
Journal Article

The Cystic Fibrosis (CF) lung harbors a complex, polymicrobial ecosystem, in which Pseudomonas aeruginosa is capable of sustaining chronic infections, which are highly resistant to multiple antibiotics. Here, we investigate the phenotypic and genotyp... Read More about Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection.

Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis (2015)
Journal Article

Copyright © ERS 2015. Pseudomonas aeruginosa produces quorum sensing signal molecules that are potential biomarkers for infection. A prospective study of 60 cystic fibrosis patients with chronic P. aeruginosa, who required intravenous antibiotics for... Read More about Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis.

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