John P. Hutchinson
In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011
Hutchinson, John P.; Fogarty, Andrew W.; McKeever, Tricia M.; Hubbard, Richard B.
Authors
ANDREW FOGARTY ANDREW.FOGARTY@NOTTINGHAM.AC.UK
Clinical Associate Professor & Reader in Clinical Epidemiology
TRICIA MCKEEVER tricia.mckeever@nottingham.ac.uk
Professor of Epidemiology and Medical Statistics
RICHARD HUBBARD richard.hubbard@nottingham.ac.uk
Blf/Gsk Professor of Epidemiological Resp Research
Abstract
Rationale: Surgical lung biopsy can help to determine a specific diagnosis in interstitial lung disease, but has associated risks. Most currently available mortality data are derived from case series and may not be generalizable to broader populations.
Objectives: We aimed to assess in-hospital mortality following surgical lung biopsy for interstitial lung disease in a national secondary care dataset from the United States.
Methods: Data were obtained from the 2000-2011 Nationwide Inpatient Sample. Cases were identified using International Classification of Diseases (ICD-9-CM) codes for interstitial lung disease and surgical lung biopsies. Lung resections and cases of lung cancer were excluded. Weighted data were used to estimate numbers of biopsies nationwide and in-hospital mortality, and multivariable logistic regression was used to adjust for sex, age, geographic region, co-morbidity, type of operation and provisional diagnosis.
Measurements and Main Results: We estimated there to be around 12,000 surgical lung biopsies performed annually for interstitial lung disease in the United States, two-thirds of which were performed electively. In-hospital mortality was 1.7% for elective procedures, but significantly higher for non-elective procedures (16.0%). Male sex, increasing age, increasing co-morbidity, open surgery and a provisional diagnosis of idiopathic pulmonary fibrosis or connective tissue disease related interstitial lung disease were risk factors for increased mortality.
Conclusions: In-hospital mortality following elective surgical lung biopsy for interstitial lung disease is just under 2%, but significantly higher for non-elective procedures. Identified risk factors for death should be taken into account when counselling patients on whether to pursue a histological diagnosis.
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 8, 2015 |
Online Publication Date | Dec 8, 2015 |
Publication Date | May 15, 2016 |
Deposit Date | Apr 19, 2016 |
Publicly Available Date | Apr 19, 2016 |
Journal | American Journal of Respiratory and Critical Care Medicine |
Print ISSN | 1073-449X |
Electronic ISSN | 1535-4970 |
Publisher | American Thoracic Society |
Peer Reviewed | Peer Reviewed |
Volume | 193 |
Issue | 10 |
Pages | 1161-1167 |
DOI | https://doi.org/10.1164/rccm.201508-1632OC |
Keywords | Interstitial lung disease, Mortality, Surgery |
Public URL | https://nottingham-repository.worktribe.com/output/789990 |
Publisher URL | http://www.atsjournals.org/doi/10.1164/rccm.201508-1632OC |
Additional Information | Originally Published in: John P Hutchinson, Andrew W Fogarty, Tricia M McKeever, and Richard B. Hubbard. In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011. American Journal of Respiratory and Critical Care Medicine 2015 ; Volume 193, issue 10, pages 1161-1167 DOI: 10.1164/rccm.201508-1632OC Copyright © 2016 by the American Thoracic Society The final publication is available at http://www.atsjournals.org/doi/10.1164/rccm.201508-1632OC |
Files
Hutchinson - In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA - online data supplement.pdf
(1.4 Mb)
PDF
Hutchinson - In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA.pdf
(970 Kb)
PDF
You might also like
Risk of Suicide After Dementia Diagnosis
(2022)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search