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Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial: Oral Glutamine Supplementation in Cystic Fibrosis

Forrester, Doug L.; Knox, Alan J.; Smyth, Alan R.; Barr, Helen L.; Simms, Rebecca; Pacey, Sarah J.; Pavord, Ian D.; Honeybourne, David; Dewar, Jane; Clayton, Andy; Fogarty, Andrew W.

Authors

Doug L. Forrester

Alan J. Knox

Alan R. Smyth

Helen L. Barr

Rebecca Simms

Sarah J. Pacey

Ian D. Pavord

David Honeybourne

Jane Dewar

Andy Clayton

ANDREW FOGARTY ANDREW.FOGARTY@NOTTINGHAM.AC.UK
Clinical Associate Professor & Reader in Clinical Epidemiology



Abstract

Rationale: Pulmonary infection and malnutrition in cystic fibrosis are associated with decreased survival. Glutamine has a possible anti-microbial effect, with a specific impact against Pseudomonas aeruginosa. We aimed to test the hypothesis that oral glutamine supplementation (21 g/day) for 8 weeks in adults with cystic fibrosis would decrease pulmonary inflammation and improve clinical status.

Methods: The study design was a randomized double-blind placebo-controlled study design with an iso-nitrogenous placebo. The primary analysis was intention to treat, and the primary outcome was change in induced sputum neutrophils.

Results: Thirty-nine individuals were recruited and thirty-six completed the study. Glutamine supplementation had no impact on any of the outcome measures in the intention-to-treat analysis. In the per protocol analysis, glutamine supplementation was associated with an increase in induced sputum neutrophils (P = 0.046), total cells (P = 0.03), and in Pseudomonas isolation agar colony forming units (P = 0.04) compared to placebo.

Conclusions: There was no effect of glutamine supplementation on markers of pulmonary inflammation in the intention-to-treat analysis.

Citation

Forrester, D. L., Knox, A. J., Smyth, A. R., Barr, H. L., Simms, R., Pacey, S. J., …Fogarty, A. W. (2016). Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial: Oral Glutamine Supplementation in Cystic Fibrosis. Pediatric Pulmonology, 51(3), 253-257. https://doi.org/10.1002/ppul.23370

Journal Article Type Article
Acceptance Date Oct 26, 2015
Online Publication Date Dec 27, 2015
Publication Date 2016-03
Deposit Date Oct 20, 2016
Publicly Available Date Mar 28, 2024
Journal Pediatric Pulmonology
Print ISSN 8755-6863
Electronic ISSN 1099-0496
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 51
Issue 3
Pages 253-257
DOI https://doi.org/10.1002/ppul.23370
Keywords glutamine
cystic fibrosis
infection
nutrition
Public URL https://nottingham-repository.worktribe.com/output/768625
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/ppul.23370/abstract
Additional Information "This is the peer reviewed version of the following article: Doug L. Forrester, Alan J. Knox, Alan R. Smyth, Helen L. Barr, Rebecca Simms, Sarah J. Pacey, Ian D. Pavord, David Honeybourne, Jane Dewar, Andy Clayton and Andrew W. Fogarty. (2016) Pediatric pulmonary 51 (3): 253-257, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/ppul.23370/full
This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."

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