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Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis

Barr, Helen L.; Halliday, Nigel; Cámara, Miguel; Barrett, David A.; Williams, Paul; Forrester, Douglas L.; Simms, Rebecca; Smyth, Alan R.; Honeybourne, David; Whitehouse, Joanna L.; Nash, Edward F.; Dewar, Jane; Clayton, Andrew; Knox, Alan J.; Fogarty, Andrew W.

Authors

Helen L. Barr

Nigel Halliday

David A. Barrett

PAUL WILLIAMS paul.williams@nottingham.ac.uk
Professor of Molecular Microbiology

Douglas L. Forrester

Rebecca Simms

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ALAN SMYTH alan.smyth@nottingham.ac.uk
Professor of Child Health

David Honeybourne

Joanna L. Whitehouse

Edward F. Nash

Jane Dewar

Andrew Clayton

Alan J. Knox

ANDREW FOGARTY andrew.fogarty@nottingham.ac.uk
Clinical Associate Professor & Reader in Clinical Epidemiology



Abstract

Copyright © ERS 2015. Pseudomonas aeruginosa produces quorum sensing signal molecules that are potential biomarkers for infection. A prospective study of 60 cystic fibrosis patients with chronic P. aeruginosa, who required intravenous antibiotics for pulmonary exacerbations, was undertaken. Clinical measurements and biological samples were obtained at the start and end of the treatment period. Additional data were available for 29 of these patients when they were clinically stable. Cross-sectionally, quorum sensing signal molecules were detectable in the sputum, plasma and urine of 86%, 75% and 83% patients, respectively. They were positively correlated between the three biofluids. Positive correlations were observed for most quorum sensing signal molecules in sputum, plasma and urine, with quantitative measures of pulmonary P. aeruginosa load at the start of a pulmonary exacerbation. Plasma concentrations of 2-nonyl-4-hydroxy-quinoline (NHQ) were significantly higher at the start of a pulmonary exacerbation compared to clinical stability ( p

Journal Article Type Article
Publication Date Jan 1, 2015
Journal European Respiratory Journal
Print ISSN 0903-1936
Electronic ISSN 1399-3003
Publisher European Respiratory Society
Peer Reviewed Peer Reviewed
Volume 46
Issue 4
Pages 1046-1054
APA6 Citation Forrester, D. L., Barr, H. L., Halliday, N., Cámara, M., Barrett, D. A., Williams, P., …Fogarty, A. W. (2015). Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis. European Respiratory Journal, 46(4), 1046-1054. https://doi.org/10.1183/09031936.00225214
DOI https://doi.org/10.1183/09031936.00225214
Keywords Pulmonary and Respiratory Medicine
Publisher URL http://erj.ersjournals.com/content/46/4/1046
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0





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