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Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis

Barr, Helen L.; Halliday, Nigel; Cámara, Miguel; Barrett, David A.; Williams, Paul; Forrester, Douglas L.; Simms, Rebecca; Smyth, Alan R.; Honeybourne, David; Whitehouse, Joanna L.; Nash, Edward F.; Dewar, Jane; Clayton, Andrew; Knox, Alan J.; Fogarty, Andrew W.


Helen L. Barr

Nigel Halliday

David A. Barrett

Professor of Molecular Microbiology

Douglas L. Forrester

Rebecca Simms

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Professor of Child Health

David Honeybourne

Joanna L. Whitehouse

Edward F. Nash

Jane Dewar

Andrew Clayton

Alan J. Knox

Clinical Associate Professor & Reader in Clinical Epidemiology


Copyright © ERS 2015. Pseudomonas aeruginosa produces quorum sensing signal molecules that are potential biomarkers for infection. A prospective study of 60 cystic fibrosis patients with chronic P. aeruginosa, who required intravenous antibiotics for pulmonary exacerbations, was undertaken. Clinical measurements and biological samples were obtained at the start and end of the treatment period. Additional data were available for 29 of these patients when they were clinically stable. Cross-sectionally, quorum sensing signal molecules were detectable in the sputum, plasma and urine of 86%, 75% and 83% patients, respectively. They were positively correlated between the three biofluids. Positive correlations were observed for most quorum sensing signal molecules in sputum, plasma and urine, with quantitative measures of pulmonary P. aeruginosa load at the start of a pulmonary exacerbation. Plasma concentrations of 2-nonyl-4-hydroxy-quinoline (NHQ) were significantly higher at the start of a pulmonary exacerbation compared to clinical stability ( p


Forrester, D. L., Barr, H. L., Halliday, N., Cámara, M., Barrett, D. A., Williams, P., …Fogarty, A. W. (2015). Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis. European Respiratory Journal, 46(4), 1046-1054.

Journal Article Type Article
Acceptance Date Apr 8, 2015
Online Publication Date May 28, 2015
Publication Date Jan 1, 2015
Deposit Date Feb 15, 2016
Publicly Available Date Feb 15, 2016
Journal European Respiratory Journal
Print ISSN 0903-1936
Electronic ISSN 1399-3003
Publisher European Respiratory Society
Peer Reviewed Peer Reviewed
Volume 46
Issue 4
Pages 1046-1054
Keywords Pulmonary and Respiratory Medicine
Public URL
Publisher URL
Copyright Statement Copyright information regarding this work can be found at the following address:


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