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Inverse association between blood pressure and pulse oximetry accuracy: an observational study in patients with suspected or confirmed COVID-19 infection (2022)
Journal Article
Crooks, C. J., West, J., Morling, J., Simmonds, M., Juurlink, I., Briggs, S., …Fogarty, A. W. (2023). Inverse association between blood pressure and pulse oximetry accuracy: an observational study in patients with suspected or confirmed COVID-19 infection. Emergency Medicine Journal, 40(3), 216-220. https://doi.org/10.1136/emermed-2022-212443

Background Pulse oximeters are a standard non-invasive tool to measure blood oxygen levels, and are used in multiple healthcare settings. It is important to understand the factors affecting their accuracy to be able to use them optimally and safely.... Read More about Inverse association between blood pressure and pulse oximetry accuracy: an observational study in patients with suspected or confirmed COVID-19 infection.

Differential pulse oximetry readings between ethnic groups and delayed transfer to intensive care units (2022)
Journal Article
Crooks, C. J., West, J., Morling, J. R., Simmonds, M., Juurlink, I., Briggs, S., …Fogarty, A. W. (2023). Differential pulse oximetry readings between ethnic groups and delayed transfer to intensive care units. QJM: An International Journal of Medicine, 116(1), 63-67. https://doi.org/10.1093/qjmed/hcac218

Summary Background Pulse oximeters are widely used to monitor blood oxygen saturations, although concerns exist that they are less accurate in individuals with pigmented skin. Aims This study aimed to determine if patients with pigmented skin were mo... Read More about Differential pulse oximetry readings between ethnic groups and delayed transfer to intensive care units.

Age modifies both the maximal temperature and inflammatory response in patients with SARS-CoV-2 infection (2022)
Journal Article
Crooks, C. J., West, J., Morling, J. R., Simmonds, M., Juurlink, I., Briggs, S., …Fogarty, A. (2022). Age modifies both the maximal temperature and inflammatory response in patients with SARS-CoV-2 infection. Clinical Medicine, 22(3), 192-196. https://doi.org/10.7861/clinmed.2021-0603

Objective To determine the maximal response of the temperature and inflammatory response to SARS-CoV-2 infection and how these are modified by age. Methods Participants were patients admitted to hospital with SARS-CoV-2 infection. For each partici... Read More about Age modifies both the maximal temperature and inflammatory response in patients with SARS-CoV-2 infection.

Patients' attitudes towards cost feedback to doctors to prevent unnecessary testing: a qualitative focus group study (2020)
Journal Article
Young, B., Fogarty, A. W., Skelly, R., Shaw, D., Thurley, P., Sturrock, N., …Cranwell, J. (2020). Patients' attitudes towards cost feedback to doctors to prevent unnecessary testing: a qualitative focus group study. Public Health, 185, 338-340. https://doi.org/10.1016/j.puhe.2020.06.023

© 2020 The Authors Objectives: There is a need to improve efficiency in healthcare delivery without compromising quality of care. One approach is the development and evaluation of behavioural strategies to reduce unnecessary use of common tests. Howe... Read More about Patients' attitudes towards cost feedback to doctors to prevent unnecessary testing: a qualitative focus group study.

Phenotypic and functional translation of IL33 genetics in asthma (2020)
Journal Article
Ketelaar, M. E., Portelli, M. A., Dijk, F. N., Shrine, N., Faiz, A., Vermeulen, C. J., …Nawijn, M. C. (2021). Phenotypic and functional translation of IL33 genetics in asthma. Journal of Allergy and Clinical Immunology, 147(1), 144-157. https://doi.org/10.1016/j.jaci.2020.04.051

© 2020 Background: Asthma is a complex disease with multiple phenotypes that may differ in disease pathobiology and treatment response. IL33 single nucleotide polymorphisms (SNPs) have been reproducibly associated with asthma. IL33 levels are elevate... Read More about Phenotypic and functional translation of IL33 genetics in asthma.

Hospital doctors’ attitudes to brief educational messages that aim to modify diagnostic test requests: a qualitative study (2020)
Journal Article
Young, B., Fogarty, A. W., Skelly, R., Shaw, D., Sturrock, N., Norwood, M., …Cranwell, J. (2020). Hospital doctors’ attitudes to brief educational messages that aim to modify diagnostic test requests: a qualitative study. BMC Medical Informatics and Decision Making, 20(1), 80. https://doi.org/10.1186/s12911-020-1087-2

BACKGROUND: Avoidable use of diagnostic tests can both harm patients and increase the cost of healthcare. Nudge-type educational interventions have potential to modify clinician behaviour while respecting clinical autonomy and responsibility, but the... Read More about Hospital doctors’ attitudes to brief educational messages that aim to modify diagnostic test requests: a qualitative study.

Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium (2020)
Journal Article
Portelli, M. A., Dijk, F. N., Ketelaar, M. E., Shrine, N., Hankinson, J., Bhaker, S., …Sayers, I. (2020). Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium. JCI insight, 5(8), Article 132446. https://doi.org/10.1172/jci.insight.132446

The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the functional mechanisms underlying these associations remain to be def... Read More about Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium.

Evaluation of the impact of a brief educational message on clinicians’ awareness of risks of ionising-radiation exposure in imaging investigations: a pilot pre-post intervention study (2019)
Journal Article
Young, B., Cranwell, J., Fogarty, A. W., Skelly, R., Sturrock, N., Norwood, M., …Thurley, P. (2019). Evaluation of the impact of a brief educational message on clinicians’ awareness of risks of ionising-radiation exposure in imaging investigations: a pilot pre-post intervention study. BMC Health Services Research, 19, https://doi.org/10.1186/s12913-019-4712-y

Background: In the context of increasing availability of computed tomography (CT) scans, judicious use of ionising radiation is a priority to minimise the risk of future health problems. Hence, education of clinicians on the risks and benefits of CT... Read More about Evaluation of the impact of a brief educational message on clinicians’ awareness of risks of ionising-radiation exposure in imaging investigations: a pilot pre-post intervention study.

Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis (2019)
Journal Article
Webb, K., Fogarty, A., Barrett, D. A., Nash, E. F., Whitehouse, J. L., Smyth, A. R., …Cámara, M. (2019). Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis. Journal of Medical Microbiology, 68(12), 1823-1828. https://doi.org/10.1099/jmm.0.001099

Introduction : Pseudomonas aeruginosa is an important respiratory pathogen in cystic fibrosis (CF), which is associated with an accelerated decline in lung function, frequent pulmonary exacerbations and increased mortality. P. aeruginosa produces in... Read More about Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis.

Does cost feedback modify demand for common blood tests in secondary care? A prospective controlled intervention study (2019)
Journal Article
Lewis, S., Young, B., Thurley, P., Shaw, D., Cranwell, J., Skelly, R., …Fogarty, A. W. (2019). Does cost feedback modify demand for common blood tests in secondary care? A prospective controlled intervention study. Future Healthcare Journal, 6(3), 204-208. https://doi.org/10.7861/fhj.2019-0001

Background: Behavioural insights or ‘nudge’ theory suggests that non-directional interventions may be used to modify human behaviour. We have tested the hypothesis that the provision of the cost of common blood tests with their results may modify sub... Read More about Does cost feedback modify demand for common blood tests in secondary care? A prospective controlled intervention study.

Changes in Asthma Mortality in England and Wales since 2001 (2019)
Journal Article
Shaw, D. E., Gaynor, C. M., & Fogarty, A. (2019). Changes in Asthma Mortality in England and Wales since 2001. Thorax, 74(12), 1174-1175. https://doi.org/10.1136/thoraxjnl-2019-213350

The number of deaths from asthma in England and Wales has not changed significantly over the last decade. This lack of improvement has received attention from both national asthma guidelines and the media. We examined asthma death data from the Offic... Read More about Changes in Asthma Mortality in England and Wales since 2001.

Evaluation of a nudge intervention providing simple feedback to clinicians of the consequence of radiation exposure on demand for computerised tomography scans: a prospective, controlled study (2019)
Journal Article
Lewis, S., Shaw, D., Langley, T., Fogarty, A., Young, B., & Cranwell, O. (2019). Evaluation of a nudge intervention providing simple feedback to clinicians of the consequence of radiation exposure on demand for computerised tomography scans: a prospective, controlled study. Clinical Medicine, 19(4), 290-293. https://doi.org/10.7861/clinmedicine.19-4-290

Computerised tomography (CT) is readily available in developed countries. As one of the side-effects includes an increased risk of cancer, interventions that may encourage more judicious use of CT scans are important. Behavioural economics theory inc... Read More about Evaluation of a nudge intervention providing simple feedback to clinicians of the consequence of radiation exposure on demand for computerised tomography scans: a prospective, controlled study.

Weight gain during acute treatment of an initial pulmonary exacerbation is associated with a longer interval to the next exacerbation in adults with cystic fibrosis (2017)
Journal Article
Barr, H. L., Cámara, M., Barrett, D., Williams, P., Forrester, D., Smyth, A., …Fogarty, A. W. (in press). Weight gain during acute treatment of an initial pulmonary exacerbation is associated with a longer interval to the next exacerbation in adults with cystic fibrosis. ERJ Open Research, 3(3), https://doi.org/10.1183/23120541.00057-2017

sTREM-1 is elevated in cystic fibrosis and correlates with proteases (2017)
Journal Article
Forrester, D., Barr, H. L., Fogarty, A., & Knox, A. (2017). sTREM-1 is elevated in cystic fibrosis and correlates with proteases. Pediatric Pulmonology, 52(4), 467-471. https://doi.org/10.1002/ppul.23650

Background: sTREM-1 (soluble triggering receptor expressed on myeloid cells-1) is a novel inflammatory marker that may be of clinical use in cystic fibrosis (CF). Dysregulation of the TREM pathway has been demonstrated in other inflammatory diseases... Read More about sTREM-1 is elevated in cystic fibrosis and correlates with proteases.

Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: a longitudinal study (2016)
Journal Article
Barr, H. L., Halliday, N., Barrett, D. A., Williams, P., Forrester, D. L., Peckham, D., …Fogarty, A. W. (2017). Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: a longitudinal study. Journal of Cystic Fibrosis, 16(2), 230-238. https://doi.org/10.1016/j.jcf.2016.10.005

Background Pulmonary P. aeruginosa infection is associated with poor outcomes in cystic fibrosis (CF) and early diagnosis is challenging, particularly in those who are unable to expectorate sputum. Specific P. aeruginosa 2-alkyl-4-quinolones are det... Read More about Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: a longitudinal study.

Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial: Oral Glutamine Supplementation in Cystic Fibrosis (2015)
Journal Article
Forrester, D. L., Knox, A. J., Smyth, A. R., Barr, H. L., Simms, R., Pacey, S. J., …Fogarty, A. W. (2016). Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial: Oral Glutamine Supplementation in Cystic Fibrosis. Pediatric Pulmonology, 51(3), 253-257. https://doi.org/10.1002/ppul.23370

Rationale: Pulmonary infection and malnutrition in cystic fibrosis are associated with decreased survival. Glutamine has a possible anti-microbial effect, with a specific impact against Pseudomonas aeruginosa. We aimed to test the hypothesis that ora... Read More about Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial: Oral Glutamine Supplementation in Cystic Fibrosis.

Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients (2015)
Journal Article
Ravipati, S., Baldwin, D. R., Barr, H. L., Fogarty, A. W., & Barrett, D. A. (in press). Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients. Metabolomics, 11(6), https://doi.org/10.1007/s11306-015-0811-x

There is a clinical need for reliable biomarkers for lung cancer that permit early diagnosis of the disease and provide prediction of histological phenotype. A prospective study design was used with a study population of patients with suspected lung... Read More about Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients.

The UK prevalence of hereditary haemorrhagic telangiectasia and its association with sex, socioeconomic status and region of residence: a population-based study (2013)
Journal Article
Donaldson, J. W., McKeever, T. M., Hall, I. P., Hubbard, R., & Fogarty, A. W. (2014). The UK prevalence of hereditary haemorrhagic telangiectasia and its association with sex, socioeconomic status and region of residence: a population-based study. Thorax, 69(2), 161-167. https://doi.org/10.1136/thoraxjnl-2013-203720

Background Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant genetic disorder of aberrant blood vessel development characterised by arteriovenous malformations. HHT is associated with significant morbidity due to complications inc... Read More about The UK prevalence of hereditary haemorrhagic telangiectasia and its association with sex, socioeconomic status and region of residence: a population-based study.