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Defining a role for lung function associated gene GSTCD in cell homeostasis (2019)
Journal Article
Henry, A. P., Probert, K., Stewart, C. E., Thakker, D., Bhaker, S., Azimi, S., …Sayers, I. (2019). Defining a role for lung function associated gene GSTCD in cell homeostasis. Respiratory Research, 20(1), doi:10.1186/s12931-019-1146-3

Genome wide association (GWA) studies have reproducibly identified signals on chromosome 4q24 associated with lung function and COPD. GSTCD (Glutathione S-transferase C-terminal domain containing) represents a candidate causal gene in this locus, how... Read More

Cross-sectional study of reversible airway obstruction in LAM: better evidence is needed for bronchodilator and inhaled steroid use (2019)
Journal Article
Johnson, J., & Johnson, S. R. (2019). Cross-sectional study of reversible airway obstruction in LAM: better evidence is needed for bronchodilator and inhaled steroid use. Thorax, doi:10.1136/thoraxjnl-2019-213338

Lymphangioleiomyomatosis can be associated with reversible airflow obstruction and although no guidelines around reversibility testing or inhaled therapy exist, many patients receive bronchodilators and inhaled corticosteroids. To better identify tho... Read More

Evaluation of a nudge intervention providing simple feedback to clinicians of the consequence of radiation exposure on demand for computerised tomography scans: a prospective, controlled study (2019)
Journal Article
Lewis, S., Shaw, D., Langley, T., Fogarty, A., Young, B., & Cranwell, O. (2019). Evaluation of a nudge intervention providing simple feedback to clinicians of the consequence of radiation exposure on demand for computerised tomography scans: a prospective, controlled study. Clinical Medicine, 19(4), 290-293. doi:10.7861/clinmedicine.19-4-290

Computerised tomography (CT) is readily available in developed countries. As one of the side-effects includes an increased risk of cancer, interventions that may encourage more judicious use of CT scans are important. Behavioural economics theory inc... Read More

A Specific Proteinase 3 Activity Footprint in Alpha-1-antitrypsin Deficiency (2019)
Journal Article
Newby, P. R., Crossley, D., Crisford, H., Stockley, J. A., Mumford, R. A., Carter, R. I., …Stockley, R. A. (2019). A Specific Proteinase 3 Activity Footprint in Alpha-1-antitrypsin Deficiency. ERJ Open Research, 5(3), doi:10.1183/23120541.00095-2019

Alpha-1-antitrypsin deficiency is a risk factor for emphysema due to tissue damage by serine proteases. Neutrophil elastase has long been considered the enzyme responsible. However, proteinase 3 also produces the pathological features of Chronic Obst... Read More

An interview analysis of coordination behaviours in out-of-hours secondary care (2019)
Journal Article
Martindale, S., Golightly, D., Pinchin, J., Shaw, D., Blakey, J., Perez, I., & Sharples, S. (2019). An interview analysis of coordination behaviours in out-of-hours secondary care. Applied Ergonomics, 81, doi:10.1016/j.apergo.2019.05.011

This paper seeks to elicit and structure the factors that shape the execution and, in particular, the coordination of work in Out of Hours care. Evenings and weekends in UK hospitals are managed by specific Out of Hours (OoH) care arrangements, and a... Read More

Increased FLYWCH1 Expression is Negatively Correlated with Wnt/β-catenin Target Gene Expression in Acute Myeloid Leukemia Cells (2019)
Journal Article
Almars, A., Chondrou, P. S., Onyido, E. K., Almozyan, S., Seedhouse, C., Babaei-Jadidi, R., & Nateri, A. S. (2019). Increased FLYWCH1 Expression is Negatively Correlated with Wnt/β-catenin Target Gene Expression in Acute Myeloid Leukemia Cells. International Journal of Molecular Sciences, 20(11), doi:10.3390/ijms20112739

Acute myeloid leukaemia (AML) is a heterogeneous clonal malignancy of hematopoietic progenitor cells. The Wnt pathway and its downstream targets are tightly regulated by β-catenin. We recently discovered a new protein, FLYWCH1, which can directly bin... Read More

The Its Not JUST Idiopathic pulmonary fibrosis Study (INJUSTIS): Description of the protocol for a multicentre prospective observational cohort study identifying biomarkers of progressive fibrotic lung disease (2019)
Journal Article
Khan, F., Stewart, I., Howard, L., McKeever, T., Jones, S., Hearson, G., …Saini, G. (2019). The Its Not JUST Idiopathic pulmonary fibrosis Study (INJUSTIS): Description of the protocol for a multicentre prospective observational cohort study identifying biomarkers of progressive fibrotic lung disease. BMJ Open Respiratory Research, 6(1), 1-7. doi:10.1136/bmjresp-2019-000439

Introduction: The Its Not JUST Idiopathic pulmonary fibrosis Study (INJUSTIS) is a multicentre, prospective, observational cohort study. The aims of this study are to identify genetic, serum and other biomarkers that may identify specific molecular m... Read More

Controlled Trial of Budesonide–Formoterol as Needed for Mild Asthma (2019)
Journal Article
Beasley, R., Holliday, M., Reddel, H. K., Braithwaite, I., Ebmeier, S., Hancox, R. J., …Weatherall, M. (2019). Controlled Trial of Budesonide–Formoterol as Needed for Mild Asthma. New England Journal of Medicine, 380(21), 1-11. doi:10.1056/nejmoa1901963

BACKGROUND In double-blind, placebo-controlled trials, budesonide–formoterol used on an as-needed basis resulted in a lower risk of severe exacerbation of asthma than as-needed use of a short-acting β2-agonist (SABA); the risk was similar to that of... Read More

Patient reported distress can aid clinical decision making in idiopathic pulmonary fibrosis: analysis of the PROFILE cohort (2019)
Journal Article
Stewart, I., McKeever, T., Braybrooke, R., Oballa, E., Simpson, J. K., Maher, T. M., …Saini, G. (2019). Patient reported distress can aid clinical decision making in idiopathic pulmonary fibrosis: analysis of the PROFILE cohort. European Respiratory Journal, 53(5), doi:10.1183/13993003.01925-2018

Idiopathic pulmonary fibrosis is a progressive and fatal interstitial lung disease. We aimed to determine if patient response to a palliative assessment survey could predict disease progression or death. We undertook a cross-sectional study in a U... Read More

Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement (2019)
Journal Article
Faas, H. M., Krupa, J. L., Taylor, A. J., Zamberlan, F., Philp, C. J., Williams, H. E., …Meersmann, T. (2019). Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement. Contrast Media and Molecular Imaging, 2019, doi:10.1155/2019/4826520

Paramagnetic gadolinium ions (Gd III), complexed within DOTA-based chelates, have become useful tools to increase the magnetic resonance imaging (MRI) contrast in tissues of interest. Recently, " on/off " probes serving as 19 F·MRI biosensor for targ... Read More

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations (2019)
Journal Article
Sakornsakolpat, P., Prokopenko, D., Lamontagne, M., Reeve, N. F., Guyatt, A. L., Jackson, V. E., …Cho, M. H. (2019). Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations. Nature Genetics, 51, 494–505. doi:10.1038/s41588-018-0342-2

Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide novel insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 control... Read More

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries (2019)
Journal Article
Shrine, N., Guyatt, A. L., Erzurumluoglu, A. M., Jackson, V. E., Hobbs, B. D., Melbourne, C. A., …Wain, L. V. (2019). New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nature Genetics, doi:10.1038/s41588-018-0321-7

Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which ar... Read More

Investigating measurements of fine particle (PM2.5) emissions from the cooking of meals and mitigating exposure using a cooker hood (2019)
Journal Article
O 'Leary, C., Kluizenaar, Y., Jacobs, P., Borsboom, W., Hall, I., & Jones, B. (2019). Investigating measurements of fine particle (PM2.5) emissions from the cooking of meals and mitigating exposure using a cooker hood. Indoor Air, 29(3), 423-438. doi:10.1111/ina.12542

There is growing awareness that indoor exposure to particulate matter with diameter ≤ 2.5μm (PM2.5) is associated with an increased risk of adverse health effects. Cooking is a key indoor source of PM2.5 and an activity conducted daily in most homes.... Read More

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 (2018)
Journal Article
Tzelepis, K., De Braekeleer, E., Aspris, D., Barbieri, I., Vijayabaskar, M. S., Liu, W., …Vassiliou, G. S. (2018). SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4. Nature Communications, 9(1), doi:10.1038/s41467-018-07620-0

We recently identified the splicing kinase gene SRPK1 as a genetic vulnerability of acute myeloid leukemia (AML). Here, we show that genetic or pharmacological inhibition of SRPK1 leads to cell cycle arrest, leukemic cell differentiation and prolonge... Read More

Patient reported distress can aid clinical decision making in idiopathic pulmonary fibrosis: analysis of the PROFILE cohort (2018)
Other
Stewart, I., McKeever, T., Braybrooke, R., Oballa, E., Simpson, J. K., Maher, T. M., …Saini, G. (2018). Patient reported distress can aid clinical decision making in idiopathic pulmonary fibrosis: analysis of the PROFILE cohort

Idiopathic pulmonary fibrosis is a progressive and fatal interstitial lung disease. We aimed to determine if patient response to a palliative assessment survey could predict disease progression or death. We undertook a cross-sectional study in a U... Read More

Genetic risk factors for the development of pulmonary disease identified by genome-wide association (2018)
Journal Article
Hall, R., Hall, I. P., & Sayers, I. (2018). Genetic risk factors for the development of pulmonary disease identified by genome-wide association. Respirology, doi:10.1111/resp.13436

Chronic respiratory diseases are a major cause of morbidity and mortality. Asthma and chronic obstructive pulmonary disease (COPD) combined affect over 500 million people worldwide. While environmental factors are important in disease progression, as... Read More

Hip fracture outcomes in patients with COPD (2018)
Journal Article
Buss, L., McKeever, T. M., Nightingale, J., Akyea, R., Ollivere, B., Moppett, I., & Bolton, C. E. (2018). Hip fracture outcomes in patients with COPD. British Journal of Anaesthesia, 121(6), 1377-1379. doi:10.1016/j.bja.2018.09.008 hideArticle Info

Hip fractures are common in patients with COPD and contemporary outcome data is needed. Patients admitted with a hip fracture to one acute trust (2010-2015) were assessed prospectively (UK National Hip Fracture Database audit) and mortality data col... Read More