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Development of dual anti-biofilm and anti-bacterial medical devices

Burroughs, Laurence; Singh, Sonali; Ashraf, Waheed; Martinez-Pomares, Luisa; Bayston, Roger; Hook, Andrew L.

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Authors

Laurence Burroughs

SONALI SINGH SONALI.SINGH@NOTTINGHAM.AC.UK
Research Development Manager

Waheed Ashraf

Roger Bayston

ANDREW HOOK ANDREW.HOOK@NOTTINGHAM.AC.UK
Assistant Professor



Abstract

The rising occurrence of antimicrobial resistance demands new strategies for delivering antibiotics to ensure their effective use. In this study, a multi-functional strategy to address medical device associated infections is explored whereby an anti-attachment and an antibacterial mechanism have been combined. Silicone catheters impregnated with multiple antibiotics are coated with polyacrylate coatings previously shown to reduce bacterial attachment and biofilm formation. Antibiotics are delivered through the applied coating and the delivery rate depends on the coating thickness and the calculated log P. Coated devices achieve a zone of inhibition and TK100 to Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus similar to those of uncoated devices, whilst maintaining anti-attachment properties. No adverse immunological responses of the coatings were observed. The multi-functional nature of the device developed in the study represents an important approach to combatting medical device associated infections.

Journal Article Type Article
Acceptance Date Jun 10, 2020
Online Publication Date Jun 10, 2020
Publication Date Jul 21, 2020
Deposit Date Jun 16, 2020
Publicly Available Date Jun 16, 2020
Journal Biomaterials science
Electronic ISSN 2047-4849
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 8
Issue 14
Pages 3926-3934
DOI https://doi.org/10.1039/d0bm00709a
Keywords General Materials Science; Biomedical Engineering
Public URL https://nottingham-repository.worktribe.com/output/4661298
Publisher URL https://pubs.rsc.org/en/content/articlelanding/2020/bm/d0bm00709a#

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