Outputs (18)

Maternal, fetal and placental selectins in women with pre-eclampsia: association with the renin-angiotensin-system (2020)
Journal Article
Mistry, H. D., Ogalde, M. V. H., Pipkin, F. B., Escher, G., & Kurlak, L. O. (2020). Maternal, fetal and placental selectins in women with pre-eclampsia: association with the renin-angiotensin-system. Frontiers in Medicine, 7, https://doi.org/10.3389/fmed.2020.00270

Selectins [endothelial (E), platelet (P), and leucocytes (L)] are a class of cell adhesion molecules, stimulated in response to inflammation. Pre-eclampsia is characterized by inflammation, and angiotensin II is pro-inflammatory. We hypothesized that... Read More about Maternal, fetal and placental selectins in women with pre-eclampsia: association with the renin-angiotensin-system.

The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia (2020)
Journal Article
Stratikos, E., Warthan, M., Strauss, J. F., Kurlak, L. O., Seamon, K., Lee, E. D., & Mistry, H. D. (2020). The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia. Frontiers in Immunology, 11, Article 396. https://doi.org/10.3389/fimmu.2020.00396

Pre-eclampsia (PE) is a disorder of pregnancy, often leading to serious and fatal complications. Endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1/ERAP2) are present in the placenta. They are involved in processes regulating blood pressure, angioge... Read More about The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia.

A pilot study of alterations in oxidized angiotensinogen and antioxidants in pre-eclamptic pregnancy (2020)
Journal Article
Dahabiyeh, L. A., Tooth, D., Kurlak, L. O., Mistry, H. D., Pipkin, F. B., & Barrett, D. A. (2020). A pilot study of alterations in oxidized angiotensinogen and antioxidants in pre-eclamptic pregnancy. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-58930-7

© 2020, The Author(s). The oxidation status of angiotensinogen (AGT) may have a critical role in pre-eclampsia. We used a validated, quantitative, mass spectrometry-based method to measure the oxidized and total AGT levels in plasma of pre-eclamptic... Read More about A pilot study of alterations in oxidized angiotensinogen and antioxidants in pre-eclamptic pregnancy.

Evidence of augmented intrarenal angiotensinogen associated with glomerular swelling in gestational hypertension and pre-eclampsia: clinical implications (2019)
Journal Article
Mistry, H. D., Kurlak, L. O., Gardner, D. S., Torffvit, O., Hansen, A., Broughton Pipkin, F., & Strevens, H. (2019). Evidence of augmented intrarenal angiotensinogen associated with glomerular swelling in gestational hypertension and pre-eclampsia: clinical implications. Journal of the American Heart Association, 8(13), 1-11. https://doi.org/10.1161/JAHA.119.012611

Background-—AGT (angiotensinogen) synthesis occurs in renal proximal tubular epithelial cells, independent from systemic AGT, as a component of the intrarenal renin–angiotensin system. We investigated urinary AGT, as a biomarker for renin–angiotensin... Read More about Evidence of augmented intrarenal angiotensinogen associated with glomerular swelling in gestational hypertension and pre-eclampsia: clinical implications.

Increased maternal and fetal cholesterol efflux capacity and placental cyp27a1 expression in pre-eclampsia (2017)
Journal Article
Mistry, H. D., Kurlak, L., Mansour, Y., Zurkinden, L., Mohaupt, M., & Escher, G. (2017). Increased maternal and fetal cholesterol efflux capacity and placental cyp27a1 expression in pre-eclampsia. Journal of Lipid Research, 58, https://doi.org/10.1194/jlr.M071985

Preeclampsia is a pregnancy-specific condition that leads to increased cardiovascular risk in later life. A decrease in cholesterol efflux capacity is linked to CVD. We hypothesized that in preeclampsia there would be a disruption of maternal/fetal p... Read More about Increased maternal and fetal cholesterol efflux capacity and placental cyp27a1 expression in pre-eclampsia.

Human placental renin–angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia–reoxygenation insult (2016)
Journal Article
Kurlak, L., Mistry, H. D., Cindrova-Davies, T., Burton, G., & Broughton Pipkin, F. (2016). Human placental renin–angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia–reoxygenation insult. Journal of Physiology, 594(5), 1327-1340. https://doi.org/10.1113/JP271045

A functioning placental renin–angiotensin system (RAS) appears necessary for uncomplicated pregnancy and is present during placentation, which occurs under low oxygen tensions. Placental RAS is increased in pre-eclampsia (PE), characterised by placen... Read More about Human placental renin–angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia–reoxygenation insult.

Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year (2015)
Journal Article
Broughton Pipkin, F., Mistry, H. D., Roy, C., Dick, B., Waugh, J., Chikhi, R., …Mohaupt, M. (2015). Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year. Endocrine Connections, 4(4), https://doi.org/10.1530/EC-15-0084

Pre-eclampsia leads to disturbed fetal organ development, including metabolic syndrome, attributed to altered pituitary-adrenal feedback loop. We measured cortisol metabolites in infants born from pre-eclamptic and normotensive women and hypothesised... Read More about Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year.

Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system (2015)
Journal Article
Kurlak, L., Williams, P. J., Bulmer, J. N., Broughton Pipkin, F., & Mistry, H. D. (2015). Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system. Placenta, 36(5), https://doi.org/10.1016/j.placenta.2015.02.011

Normal placentation occurs under low oxygen tensions yet hypoxia is also implicated in placental pathologies such as pre-eclampsia (PE). Hypoxia-inducible factors (HIFs), adenosine and tissue renin-angiotensin-system (RAS) are known to promote angiog... Read More about Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system.

Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia (2014)
Journal Article
Mistry, H. D., Gill, C., Kurlak, L., Seed, P. T., Hestketh, J., Meplan, C., …Poston, L. (2015). Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia. Free Radical Biology and Medicine, 78, https://doi.org/10.1016/j.freeradbiomed.2014.10.580

Aims: Pre-eclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality. Deficiencies of specific micronutrient antioxidant activities associated with copper, selenium, zinc... Read More about Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia.

Expression of voltage-dependent potassium channels in first trimester human placentae (2014)
Journal Article
Mistry, H. D., Kurlak, L., Whitley, G. S., Cartwright, J. E., Broughton Pipkin, F., & Tribe, R. M. (2014). Expression of voltage-dependent potassium channels in first trimester human placentae. Placenta, 35(5), https://doi.org/10.1016/j.placenta.2014.02.008

Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (Kv7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCN... Read More about Expression of voltage-dependent potassium channels in first trimester human placentae.