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Outputs (37)

Engineered neural tissue made using hydrogels derived from decellularised tissues for the regeneration of peripheral nerves (2022)
Journal Article
Kellaway, S. C., Roberton, V., Jones, J. N., Loczenski, R., Phillips, J. B., & White, L. J. (2023). Engineered neural tissue made using hydrogels derived from decellularised tissues for the regeneration of peripheral nerves. Acta Biomaterialia, 157, 124-136. https://doi.org/10.1016/j.actbio.2022.12.003

Engineered neural tissue (EngNT) promotes in vivo axonal regeneration. Decellularised materials (dECM) are complex biologic scaffolds that can improve the cellular environment and also encourage positive tissue remodelling in vivo. We hypothesised th... Read More about Engineered neural tissue made using hydrogels derived from decellularised tissues for the regeneration of peripheral nerves.

Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease (2022)
Journal Article
Li, X., Li, T., Zhan, F., Cheng, F., Lu, L., Zhang, B., …Yao, H. (2022). Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease. ACS Chemical Neuroscience, 13(23), 3488-3501. https://doi.org/10.1021/acschemneuro.2c00520

Based on a multitarget strategy, a series of novel chromanone-1-benzyl-1,2,3,6-tetrahydropyridin hybrids were identified for the potential treatment of Alzheimer's disease (AD). Biological evaluation demonstrated that these hybrids exhibited signific... Read More about Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease.

Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease (2022)
Journal Article
Li, X., Li, T., Zhang, P., Li, X., Lu, L., Sun, Y., …Xu, J. (2022). Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease. European Journal of Medicinal Chemistry, 244, Article 114841. https://doi.org/10.1016/j.ejmech.2022.114841

Based on the multitarget strategy, a series of novel clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine hybrids were identified for the potential treatment of Alzheimer's disease (AD). Biological evaluation in vitro revealed that these hybrids exhibited... Read More about Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease.

Printing biohybrid materials for bioelectronic cardio-3D-cellular constructs (2022)
Journal Article
Sanjuan-Alberte, P., Whitehead, C., Jones, J. N., Silva, J. C., Carter, N., Kellaway, S., …Rawson, F. J. (2022). Printing biohybrid materials for bioelectronic cardio-3D-cellular constructs. iScience, 25(7), Article 104552. https://doi.org/10.1016/j.isci.2022.104552

Conductive hydrogels are emerging as promising materials for bioelectronic applications as they minimize the mismatch between biological and electronic systems. We propose a strategy to bioprint biohybrid conductive bioinks based on decellularized ex... Read More about Printing biohybrid materials for bioelectronic cardio-3D-cellular constructs.

Ovarian extracellular matrix‐based hydrogel for human ovarian follicle survival in vivo: A pilot work (2021)
Journal Article
Chiti, M., Vanacker, J., Ouni, E., Tatic, N., Viswanath, A., des Rieux, A., …Amorim, C. A. (2022). Ovarian extracellular matrix‐based hydrogel for human ovarian follicle survival in vivo: A pilot work. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 110(5), 1012-1022. https://doi.org/10.1002/jbm.b.34974

To successfully assemble a bio-engineered ovary, we need to create a three-dimensional matrix able to accommodate isolated follicles and cells. The goal of this study was to develop an extracellular matrix hydrogel (oECM) derived from decellularized... Read More about Ovarian extracellular matrix‐based hydrogel for human ovarian follicle survival in vivo: A pilot work.

Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model (2021)
Journal Article
Markides, H., Foster, N. C., McLaren, J. S., Hopkins, T., Black, C., Oreffo, R. O. C., …El Haj, A. J. (2021). Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model. Cells, 10(7), Article 1776. https://doi.org/10.3390/cells10071776

The ovine critical-sized defect model provides a robust preclinical model for testing tissue-engineered constructs for use in the treatment of non-union bone fractures and severe trauma. A critical question in cell-based therapies is understanding th... Read More about Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model.

Matrix-Bound Nanovesicles: The Effects of Isolation Method upon Yield, Purity, and Function (2020)
Journal Article
Quijano, L. M., Naranjo, J. D., El-Mossier, S. O., Turner, N. J., Pineda Molina, C., Bartolacci, J., …Badylak, S. F. (2020). Matrix-Bound Nanovesicles: The Effects of Isolation Method upon Yield, Purity, and Function. Tissue Engineering Part C Methods, 26(10), 528-540. https://doi.org/10.1089/ten.tec.2020.0243

Identification of matrix-bound nanovesicles (MBV) as ubiquitous components of the extracellular matrix (ECM) raises questions regarding their biologic functions and their potential theranostic application. Unlike liquid-phase extracellular vesicles (... Read More about Matrix-Bound Nanovesicles: The Effects of Isolation Method upon Yield, Purity, and Function.

Characterisation and evaluation of the regenerative capacity of Stro-4+ enriched bone marrow mesenchymal stromal cells using bovine extracellular matrix hydrogel and a novel biocompatible melt electro-written medical-grade polycaprolactone scaffold (2020)
Journal Article
Black, C., Kanczler, J., de Andrés, M., White, L., Savi, F., Bas, O., …Oreffo, R. (2020). Characterisation and evaluation of the regenerative capacity of Stro-4+ enriched bone marrow mesenchymal stromal cells using bovine extracellular matrix hydrogel and a novel biocompatible melt electro-written medical-grade polycaprolactone scaffold. Biomaterials, 247, Article 119998. https://doi.org/10.1016/j.biomaterials.2020.119998

Many skeletal tissue regenerative strategies centre around the multifunctional properties of bone marrow derived stromal cells (BMSC) or mesenchymal stem/stromal cells (MSC)/bone marrow derived skeletal stem cells (SSC). Specific identification of th... Read More about Characterisation and evaluation of the regenerative capacity of Stro-4+ enriched bone marrow mesenchymal stromal cells using bovine extracellular matrix hydrogel and a novel biocompatible melt electro-written medical-grade polycaprolactone scaffold.

Stem cells from the dental apical papilla in extracellular matrix hydrogels mitigate inflammation of microglial cells (2019)
Journal Article
Tatic, N., Rose, F. R., des Rieux, A., & White, L. J. (2019). Stem cells from the dental apical papilla in extracellular matrix hydrogels mitigate inflammation of microglial cells. Scientific Reports, 9, https://doi.org/10.1038/s41598-019-50367-x

After spinal cord injury (SCI) chronic inflammation hampers regeneration. Influencing the local microenvironment after SCI may provide a strategy to modulate inflammation and the immune response. The objectives of this work were to determine whether... Read More about Stem cells from the dental apical papilla in extracellular matrix hydrogels mitigate inflammation of microglial cells.

Nanofibrous scaffolds support a 3D in vitro permeability model of the human intestinal epitheleum (2019)
Journal Article
Patient, J. D., Hajiali, H., Harris, K., Abrahamsson, B., Tannergreen, C., White, L. J., …Rose, F. R. (2019). Nanofibrous scaffolds support a 3D in vitro permeability model of the human intestinal epitheleum. Frontiers in Pharmacology, 10, Article 456. https://doi.org/10.3389/fphar.2019.00456

Advances in drug research not only depend on high throughput screening to evaluate large numbers of lead compounds but also on the development of in vitro models which can simulate human tissues in terms of drug permeability and functions. Potential... Read More about Nanofibrous scaffolds support a 3D in vitro permeability model of the human intestinal epitheleum.

Microparticles for controlled GDF6 delivery to direct ASC?based nucleus pulposus regeneration (2019)
Journal Article
Hodgkinson, T., Stening, J. Z., White, L. J., Shakesheff, K. M., Hoyland, J. A., & Richardson, S. M. (2019). Microparticles for controlled GDF6 delivery to direct ASC?based nucleus pulposus regeneration. Journal of Tissue Engineering and Regenerative Medicine, 13(8), 1406-1417. https://doi.org/10.1002/term.2882

Currently, there is no effective long-term treatment for intervertebral disc degeneration (IVDD), making it an attractive candidate for regenerative therapies. Hydrogel delivery of adipose stem cells (ASCs) in combination with controlled release of b... Read More about Microparticles for controlled GDF6 delivery to direct ASC?based nucleus pulposus regeneration.

Targeted protein delivery: carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds (2019)
Journal Article
Tanase, C. E., Qutachi, O., White, L. J., Shakesheff, K. M., McCaskie, A. W., Best, S. M., & Cameron, R. E. (2019). Targeted protein delivery: carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds. Regenerative Biomaterials, 6(5), 279-287. https://doi.org/10.1093/rb/rbz015

Tissue engineering response may be tailored via controlled, sustained release of active agents from protein loaded degradable microparticles incorporated directly within 3D ice-templated collagen scaffolds. However, the effects of covalent crosslink... Read More about Targeted protein delivery: carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds.

A thermoresponsive three-dimensional fibrous cell culture platform for enzyme-free expansion of mammalian cells (2019)
Journal Article
Aladdad, A. M., Amer, M. H., Sidney, L., Hopkinson, A., White, L. J., Alexander, C., & Rose, F. R. (2019). A thermoresponsive three-dimensional fibrous cell culture platform for enzyme-free expansion of mammalian cells. Acta Biomaterialia, 95, 427-438. https://doi.org/10.1016/j.actbio.2019.01.037

A three-dimensional thermoresponsive fibrous scaffold system for the subsequent extended culture and enzyme-free passaging of a range of mammalian cell types is presented. Poly(PEGMA188) was incorporated with poly(ethylene terephthalate) (PET) via bl... Read More about A thermoresponsive three-dimensional fibrous cell culture platform for enzyme-free expansion of mammalian cells.

In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft (2018)
Journal Article
Rose, J., Sidney, L., Patient, J., White, L., Dua, H., El Haj, A., …Rose, F. (2018). In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft. Journal of Biomedical Materials Research Part A, 107(4), 828-838. https://doi.org/10.1002/jbm.a.36598

The advent of innovative surgical procedures utilizing partial thickness corneal grafts has created a need for the development of synthetic implants to recreate corneal stromal tissue. This work evaluates electrospun gelatin and polycaprolactone (PCL... Read More about In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft.

Translation of remote control regenerative technologies for bone repair (2018)
Journal Article
Markides, H., McLaren, J. S., Telling, N. D., Alom, N., Al-Mutheffer, E. A., Oreffo, R., …El-Haj, A. (2018). Translation of remote control regenerative technologies for bone repair. npj Regenerative Medicine, 3(9), 1-12. https://doi.org/10.1038/s41536-018-0048-1

The role of biomechanical stimuli, or mechanotransduction, in normal bone homeostasis and repair is understood to facilitate effective osteogenesis of mesenchymal stem cells (MSCs) in vitro. Mechanotransduction has been integrated into a multitude of... Read More about Translation of remote control regenerative technologies for bone repair.

A biomaterials approach to influence stem cell fate in injectable cell-based therapies (2018)
Journal Article
Amer, M. H., Rose, F. R., Shakesheff, K. M., & White, L. J. (2018). A biomaterials approach to influence stem cell fate in injectable cell-based therapies. Stem Cell Research and Therapy, 9(39), https://doi.org/10.1186/s13287-018-0789-1

Background: Numerous stem cell therapies use injection-based administration to deliver high density cell preparations. However, cell retention rates as low as 1% have been observed within days of transplantation. This study investigated the effects o... Read More about A biomaterials approach to influence stem cell fate in injectable cell-based therapies.

Peptide hydrogels — a tissue engineering strategy for the prevention of oesophageal strictures (2017)
Journal Article
Kumar, D., Workman, V., O'Brien, M. C., McLaren, J. S., White, L. J., Ragunath, K., …Rose, F. R. (2017). Peptide hydrogels — a tissue engineering strategy for the prevention of oesophageal strictures. Advanced Functional Materials, 27(38), Article 1702424. https://doi.org/10.1002/adfm.201702424

Endoscopic treatment of Barrett’s oesophagus often leads to further damage of healthy tissue causing fibrotic tissue formation termed as strictures. This study shows that synthetic, self-assembling peptide hydrogels (PeptiGelDesign) support the activ... Read More about Peptide hydrogels — a tissue engineering strategy for the prevention of oesophageal strictures.

Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges (2017)
Journal Article
Amer, M. H., Rose, F. R., Shakesheff, K. M., Modo, M., & White, L. J. (in press). Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges. npj Regenerative Medicine, 2, Article 23. https://doi.org/10.1038/s41536-017-0028-x

Significant progress has been made during the past decade towards the clinical adoption of cell- based therapeutics. However, existing cell delivery approaches have shown limited success, with numerous studies showing fewer than 5% of injected cells... Read More about Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges.

Decellularized bone extracellular matrix and human dental pulp stem cells as a construct for bone regeneration (2017)
Journal Article
Paduano, F., Marrelli, M., Alom, N., Amer, M. H., White, L. J., Shakesheff, K. M., & Tatullo, M. (in press). Decellularized bone extracellular matrix and human dental pulp stem cells as a construct for bone regeneration. Journal of Biomaterials Science, Polymer Edition, 28(8), https://doi.org/10.1080/09205063.2017.1301770

Dental pulp tissue represents a source of mesenchymal stem cells (MSCs) that have a strong differentiation potential towards the osteogenic lineage. The objective of the current study was to examine in vitro osteogenic induction of dental pulp stem c... Read More about Decellularized bone extracellular matrix and human dental pulp stem cells as a construct for bone regeneration.

Macrophage phenotype in response to ECM bioscaffolds (2017)
Journal Article
Huleihel, L., Dziki, J. L., Bartolacci, J. G., Rausch, T., Scarritt, M. E., Cramer, M. C., …Badylak, S. F. (2017). Macrophage phenotype in response to ECM bioscaffolds. Seminars in Immunology, 29, https://doi.org/10.1016/j.smim.2017.04.004

Macrophage presence and phenotype are critical determinants of the healing response following injury. Downregulation of the pro-inflammatory macrophage phenotype has been associated with the therapeutic use of bioscaffolds composed of extracellular... Read More about Macrophage phenotype in response to ECM bioscaffolds.

Surface modification of PdlLGA microspheres with gelatine methacrylate: evaluation of adsorption, entrapment, and oxygen plasma treatment approaches (2017)
Journal Article
Baki, A., Rahman, C. V., White, L. J., Scurr, D. J., Qutachi, O., & Shakesheff, K. M. (2017). Surface modification of PdlLGA microspheres with gelatine methacrylate: evaluation of adsorption, entrapment, and oxygen plasma treatment approaches. Acta Biomaterialia, 53, 450-459. https://doi.org/10.1016/j.actbio.2017.01.042

Injectable poly (dl-lactic-co-glycolic acid) (PdlLGA) microspheres are promising candidates as biodegradable controlled release carriers for drug and cell delivery applications; however, they have limited functional groups on the surface to enable de... Read More about Surface modification of PdlLGA microspheres with gelatine methacrylate: evaluation of adsorption, entrapment, and oxygen plasma treatment approaches.

The impact of detergents on the tissue decellularization process: a ToF-SIMS study (2016)
Journal Article
White, L. J., Taylor, A. J., Faulk, D. M., Keane, T. J., Saldin, L. T., Reing, J. E., …Badylak, S. F. (2017). The impact of detergents on the tissue decellularization process: a ToF-SIMS study. Acta Biomaterialia, 50, https://doi.org/10.1016/j.actbio.2016.12.033

Biologic scaffolds are derived from mammalian tissues, which must be decellularized to remove cellular antigens that would otherwise incite an adverse immune response. Although widely used clinically, the optimum balance between cell removal and the... Read More about The impact of detergents on the tissue decellularization process: a ToF-SIMS study.

Extracellular matrix hydrogels from decellularized tissues: structure and function (2016)
Journal Article
Saldin, L. T., Cramer, M. C., Velankar, S. S., White, L. J., & Badylak, S. F. (2017). Extracellular matrix hydrogels from decellularized tissues: structure and function. Acta Biomaterialia, 49, https://doi.org/10.1016/j.actbio.2016.11.068

Extracellular matrix (ECM) bioscaffolds prepared from decellularized tissues have been used to facilitate constructive and functional tissue remodeling in a variety of clinical applications. The discovery that these ECM materials could be solubilized... Read More about Extracellular matrix hydrogels from decellularized tissues: structure and function.

Extracellular matrix-derived hydrogels for dental stem cell delivery (2016)
Journal Article
Viswanath, A., Vanacker, J., Germain, L., Leprince, J. G., Diogenes, A., Shakesheff, K. M., …des Rieux, A. (2016). Extracellular matrix-derived hydrogels for dental stem cell delivery. Journal of Biomedical Materials Research Part A, 105(1), 319-328. https://doi.org/10.1002/jbm.a.35901

Decellularised mammalian extracellular matrices (ECM) have been widely accepted as an ideal substrate for repair and remodelling of numerous tissues in clinical and pre-clinical studies. Recent studies have demonstrated the ability of ECM scaffolds d... Read More about Extracellular matrix-derived hydrogels for dental stem cell delivery.

Restoring Mucosal Barrier Function and Modifying Macrophage Phenotype with an Extracellular Matrix Hydrogel: Potential Therapy for Ulcerative Colitis (2016)
Journal Article
Keane, T. J., Dziki, J., Sobieski, E., Smoulder, A., Castleton, A. A., Turner, N. J., …Badylak, S. F. (2017). Restoring Mucosal Barrier Function and Modifying Macrophage Phenotype with an Extracellular Matrix Hydrogel: Potential Therapy for Ulcerative Colitis. Journal of Crohn's and Colitis, 11(3), 360-368. https://doi.org/10.1093/ecco-jcc/jjw149

Background and Aims: Despite advances in therapeutic options, more than half of all patients with ulcerative colitis [UC] do not achieve long-term remission, many require colectomy, and the disease still has a marked negative impact on quality of lif... Read More about Restoring Mucosal Barrier Function and Modifying Macrophage Phenotype with an Extracellular Matrix Hydrogel: Potential Therapy for Ulcerative Colitis.

A detailed assessment of varying ejection rate on delivery efficiency of mesenchymal stem cells using narrow-bore needles (2016)
Journal Article
Rose, F., Shakesheff, K., White, L., & Amer, M. (2016). A detailed assessment of varying ejection rate on delivery efficiency of mesenchymal stem cells using narrow-bore needles. Stem Cells Translational Medicine, 5(3), 366-378. doi:10.5966/sctm.2015-0208

As the number of clinical trials exploring cell therapy rises, a thorough understanding of the limits of cell delivery is essential. We used an extensive toolset comprising various standard and multiplex assays for the assessment of cell delivery pos... Read More about A detailed assessment of varying ejection rate on delivery efficiency of mesenchymal stem cells using narrow-bore needles.

Odontogenic differentiation of human dental pulp stem cells on hydrogel scaffolds derived from decellularized bone extracellular matrix and collagen type I (2016)
Journal Article
Paduano, F., Marrelli, M., White, L. J., Shakesheff, K., & Tatullo, M. (2016). Odontogenic differentiation of human dental pulp stem cells on hydrogel scaffolds derived from decellularized bone extracellular matrix and collagen type I. PLoS ONE, 11(2), 1-18. https://doi.org/10.1371/journal.pone.0148225

Objectives The aim of this study was to evaluate the level of odontogenic differentiation of dental pulp stem cells (DPSCs) on hydrogel scaffolds derived from bone extracellular matrix (bECM) in comparison to those seeded on collagen I (Col-I), on... Read More about Odontogenic differentiation of human dental pulp stem cells on hydrogel scaffolds derived from decellularized bone extracellular matrix and collagen type I.

A Thermoresponsive and Magnetic Colloid for 3D Cell Expansion and Reconfiguration (2014)
Journal Article
Saunders, B. R., Gould, T., Saeed, A. O., Francini, N., White, L., Dixon, J. E., …Shakesheff, K. M. (2015). A Thermoresponsive and Magnetic Colloid for 3D Cell Expansion and Reconfiguration. Advanced Materials, 27(4), 662-668. https://doi.org/10.1002/adma.201403626

A dual thermoresponsive and magnetic colloidal gel matrix is described for enhanced stem-cell culture. The combined properties of the material allow enzyme-free passaging and expansion of mesenchymal stem cells, as well as isolation of cells postcult... Read More about A Thermoresponsive and Magnetic Colloid for 3D Cell Expansion and Reconfiguration.

Formulations for modulation of protein release from large-size PLGA microparticles for tissue engineering (2014)
Journal Article
Qodratnama, R., Pio Serino, L., Cox, H., Qutachi, O., & White, L. J. (2015). Formulations for modulation of protein release from large-size PLGA microparticles for tissue engineering. Materials Science and Engineering: C, 47, 230-236. doi:10.1016/j.msec.2014.11.003

In this study we present an approach to pre-program lysozyme release from large size (100–300 μm) poly(dl-lactic acid-co-glycolic acid) (PLGA) microparticles. This approach involved blending in-house synthesized triblock copolymers with a PLGA 85:15.... Read More about Formulations for modulation of protein release from large-size PLGA microparticles for tissue engineering.

Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model (2014)
Journal Article
Smith, E., Rose, F., Kanczler, J., Shakesheff, K., Gothard, D., White, L., …Oreffoa, R. (2014). Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model. Acta Biomaterialia, 10(10), 4186-4196. https://doi.org/10.1016/j.actbio.2014.06.011

Current clinical treatments for skeletal conditions resulting in large-scale bone loss include autograft or allograft, both of which have limited effectiveness. In seeking to address bone regeneration, several tissue engineering strategies have come... Read More about Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model.

A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis in a contaminated in vivo bone defect model (2014)
Journal Article
McLaren, J. S., White, L., Cox, H., Ashraf, W., Rahman, C., Blunn, G., …Scammell, B. E. (2014). A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis in a contaminated in vivo bone defect model. eCells and Materials Journal, 27, 332-349. https://doi.org/10.22203/eCM.v027a24

Open fractures are at risk of serious infection and, if infected, require several surgical interventions and courses of systemic antibiotics. We investigated a new injectable formulation that simultaneously hardens in vivo to form a porous scaffold f... Read More about A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis in a contaminated in vivo bone defect model.

A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis and encourage new bone growth (2014)
Journal Article
McLaren, J. S., Bayston, R., White, L. J., Cox, H. C., Ashraf, W., Rahman, C. V., …Scammell, B. E. (2014). A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis and encourage new bone growth. eCells and Materials Journal, 27, 332-349. https://doi.org/10.22203/eCM.v027a24

Open fractures are at risk of serious infection and, if infected, require several surgical interventions and courses of systemic antibiotics. We investigated a new injectable formulation that simultaneously hardens in vivo to form a porous scaffold f... Read More about A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis and encourage new bone growth.

Evaluation of skeletal tissue repair, Part 2: Enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model (2014)
Journal Article
Smith, E., Felicity, R., Kanczler, J., Shakesheff, K., Gothard, D., White, L., …Oreffoa, R. (2014). Evaluation of skeletal tissue repair, Part 2: Enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model. Acta Biomaterialia, 10(10), 4197-4205. https://doi.org/10.1016/j.actbio.2014.05.025

There is an unmet need for improved, effective tissue engineering strategies to replace or repair bone damaged through disease or injury. Recent research has focused on developing biomaterial scaffolds capable of spatially and temporally releasing co... Read More about Evaluation of skeletal tissue repair, Part 2: Enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model.

Uniform cell colonization of porous 3-D scaffolds achieved using radial control of surface chemistry (2011)
Journal Article
Intranuovo, F., Howard, D., White, L. J., Johal, R. K., Ghaemmaghami, A. M., Favia, P., …Alexander, M. R. (2011). Uniform cell colonization of porous 3-D scaffolds achieved using radial control of surface chemistry. Acta Biomaterialia, 7(9), 3336-3344. https://doi.org/10.1016/j.actbio.2011.05.020

Uniform cellular distribution is a prerequisite to forming tissue within porous scaffolds, but the seeding process often results in preferential adhesion of cells at the periphery. We develop a vapour phase coating strategy which is readily applicabl... Read More about Uniform cell colonization of porous 3-D scaffolds achieved using radial control of surface chemistry.