Skip to main content

Research Repository

Advanced Search

Professor FELICITY ROSE's Outputs (62)

3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review (2017)
Journal Article
Prina, E., Mistry, P., Sidney, L. E., Yang, J., Wildman, R. D., Bertolin, M., Breda, C., Ferrari, B., Barbaro, V., Hopkinson, A., Dua, H. S., Ferrari, S., & Rose, F. R. A. (2017). 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review. Stem Cell Reviews and Reports, 13(3), 430-441. https://doi.org/10.1007/s12015-017-9740-6

In recent years, there has been increased research interest in generating corneal substitutes, either for use in the clinic or as in vitro corneal models. The advancement of 3D microfabrication technologies has allowed the reconstruction of the nativ... Read More about 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review.

Feasibility of spatially-offset Raman spectroscopy for in-vitro and in-vivo monitoring mineralisation of bone tissue-engineering scaffolds (2016)
Journal Article
Liao, Z., Sinjab, F., Nommeots-Nomm, A., Jones, J., Ruiz-Cantu, L., Yang, J., Rose, F., & Notingher, I. (2017). Feasibility of spatially-offset Raman spectroscopy for in-vitro and in-vivo monitoring mineralisation of bone tissue-engineering scaffolds. Analytical Chemistry, 89(1), 847-853. https://doi.org/10.1021/acs.analchem.6b03785

We investigated the feasibility of using spatially-offset Raman spectroscopy (SORS) for non-destructive characterisation of bone tissue engineering scaffolds. The deep regions of these scaffolds, or scaffolds implanted subcutaneously in live animals,... Read More about Feasibility of spatially-offset Raman spectroscopy for in-vitro and in-vivo monitoring mineralisation of bone tissue-engineering scaffolds.

A new photocrosslinkable polycaprolactone based ink for three dimensional inkjet printing (2016)
Journal Article
He, Y., Tuck, C., Prina, E., Kilsby, S., Christie, S. D., Edmondson, S., Hague, R. J., Rose, F. R., & Wildman, R. D. (2017). A new photocrosslinkable polycaprolactone based ink for three dimensional inkjet printing. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 105(6), 1645-1657. https://doi.org/10.1002/jbm.b.33699

A new type of photocrosslinkable polycaprolactone
(PCL)-based ink that is suitable for three-dimensional (3D) inkjet printing has been developed. Photocrosslinkable PCL dimethylacrylate was synthesized and mixed with poly(ethylene glycol) diacrylate... Read More about A new photocrosslinkable polycaprolactone based ink for three dimensional inkjet printing.

Surface chemistry of Ti6Al4V components fabricated using selective laser melting for biomedical applications (2016)
Journal Article
Vaithilingam, J., Prina, E., Goodridge, R. D., Hague, R. J., Edmondson, S., Rose, F. R., & Christie, S. D. (2016). Surface chemistry of Ti6Al4V components fabricated using selective laser melting for biomedical applications. Materials Science and Engineering: C, 67, 294-303. https://doi.org/10.1016/j.msec.2016.05.054

Selective laser melting (SLM) has previously been shown to be a viable method for fabricating biomedical implants; however, the surface chemistry of SLM fabricated parts is poorly understood. In this study, X-ray photoelectron spectroscopy (XPS) was... Read More about Surface chemistry of Ti6Al4V components fabricated using selective laser melting for biomedical applications.

Disc colours in field and cluster spiral galaxies at 0.5 ≲z≲ 0.8 (2016)
Journal Article
Cantale, N., Jablonka, P., Courbin, F., Rudnick, G., Zaritsky, D., Meylan, G., Desai, V., De Lucia, G., Aragón-Salamanca, A., Poggianti, B. M., Finn, R., & Simard, L. (2016). Disc colours in field and cluster spiral galaxies at 0.5 ≲z≲ 0.8. Astronomy and Astrophysics, 589, Article A82. https://doi.org/10.1051/0004-6361/201525801

We present a detailed study of the colours of late-type galaxy discs for ten of the EDisCS galaxy clusters with 0.5 ≲ z ≲ 0.8. Our cluster sample contains 172 spiral galaxies, and our control sample is composed of 96 field disc galaxies. We deconvolv... Read More about Disc colours in field and cluster spiral galaxies at 0.5 ≲z≲ 0.8.

A detailed assessment of varying ejection rate on delivery efficiency of mesenchymal stem cells using narrow-bore needles (2016)
Journal Article
Rose, F., Shakesheff, K., White, L., & Amer, M. (2016). A detailed assessment of varying ejection rate on delivery efficiency of mesenchymal stem cells using narrow-bore needles. Stem Cells Translational Medicine, 5(3), 366-378. https://doi.org/10.5966/sctm.2015-0208

As the number of clinical trials exploring cell therapy rises, a thorough understanding of the limits of cell delivery is essential. We used an extensive toolset comprising various standard and multiplex assays for the assessment of cell delivery pos... Read More about A detailed assessment of varying ejection rate on delivery efficiency of mesenchymal stem cells using narrow-bore needles.

In vivo assessment of bone regeneration in alginate/bone ECM hydrogels with incorporated skeletal stem cells and single growth factors (2015)
Journal Article
Gothard, D., Smith, E. L., Kanczler, J. M., Black, C. R., Wells, J. A., Roberts, C. A., White, L., Qutachi, O., Peto, H., Rashidi, H., Rojo, L., Stevens, M. M., El Haj, A. J., Rose, F., Shakesheff, K., & Oreffo, R. O. (2015). In vivo assessment of bone regeneration in alginate/bone ECM hydrogels with incorporated skeletal stem cells and single growth factors. PLoS ONE, 10(12), Article e0145080. https://doi.org/10.1371/journal.pone.0145080

Adapting the electrospinning process to provide three unique environments for a tri-layered in vitro model of the airway wall (2015)
Journal Article
Bridge, J. C., Aylott, J. W., Brightling, C. E., Ghaemmaghami, A. M., Knox, A. J., Lewis, M. P., Rose, F., & Morris, G. E. (2015). Adapting the electrospinning process to provide three unique environments for a tri-layered in vitro model of the airway wall. Journal of Visualized Experiments, 101, Article e52986. https://doi.org/10.3791/52986

Electrospinning is a highly adaptable method producing porous 3D fibrous scaffolds that can be exploited in in vitro cell culture. Alterations to intrinsic parameters within the process allow a high degree of control over scaffold characteristics inc... Read More about Adapting the electrospinning process to provide three unique environments for a tri-layered in vitro model of the airway wall.

Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds (2014)
Journal Article
Morris, G., Bridge, J., Eltboli, O., Lewis, M., Knox, A., Aylott, J. W., Brightling, C., Ghaemmaghami, A., & Rose, F. R. (2014). Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds. AJP - Lung Cellular and Molecular Physiology, 307(1), Article L38-L47. https://doi.org/10.1152/ajplung.00318.2013

Human airway smooth muscle (HASM) contraction plays a central role in regulating airway resistance in both healthy and asthmatic bronchioles. In vitro studies that investigate the intricate mechanisms that regulate this contractile process are predom... Read More about Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds.

Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model (2014)
Journal Article
Smith, E., Rose, F., Kanczler, J., Shakesheff, K., Gothard, D., White, L., Roberts, C., Wells, J., Qutachi, O., Sawkins, M., Peto, H., Rashidi, H., Rojocd, L., Stevens, M., El Haj, A., & Oreffoa, R. (2014). Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model. Acta Biomaterialia, 10(10), 4186-4196. https://doi.org/10.1016/j.actbio.2014.06.011

Current clinical treatments for skeletal conditions resulting in large-scale bone loss include autograft or allograft, both of which have limited effectiveness. In seeking to address bone regeneration, several tissue engineering strategies have come... Read More about Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model.

A novel electrospun biphasic scaffold provides optimal three-dimensional topography forin vitroco-culture of airway epithelial and fibroblast cells (2014)
Journal Article
Morris, G., Bridge, J., Brace, L., Knox, A., Aylott, J. W., Brightling, C., Ghaemmaghami, A. M., & Rose, F. R. (2014). A novel electrospun biphasic scaffold provides optimal three-dimensional topography forin vitroco-culture of airway epithelial and fibroblast cells. Biofabrication, 6(3), Article 035014. https://doi.org/10.1088/1758-5082/6/3/035014

Conventional airway in vitro models focus upon the function of individual structural cells cultured in a two-dimensional monolayer, with limited three-dimensional (3D) models of the bronchial mucosa. Electrospinning offers an attractive method to pro... Read More about A novel electrospun biphasic scaffold provides optimal three-dimensional topography forin vitroco-culture of airway epithelial and fibroblast cells.

Evaluation of skeletal tissue repair, Part 2: Enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model (2014)
Journal Article
Smith, E., Felicity, R., Kanczler, J., Shakesheff, K., Gothard, D., White, L., Roberts, C., Wells, J., Qutachi, O., Sawkins, M., Peto, H., Rashidi, H., Rojocd, L., Stevens, M., El Haj, A., & Oreffoa, R. (2014). Evaluation of skeletal tissue repair, Part 2: Enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model. Acta Biomaterialia, 10(10), 4197-4205. https://doi.org/10.1016/j.actbio.2014.05.025

There is an unmet need for improved, effective tissue engineering strategies to replace or repair bone damaged through disease or injury. Recent research has focused on developing biomaterial scaffolds capable of spatially and temporally releasing co... Read More about Evaluation of skeletal tissue repair, Part 2: Enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model.

A novel technique for the production of electrospun scaffolds with tailored three-dimensional micro-patterns employing additive manufacturing (2014)
Journal Article
Rogers, C. M., Morris, G. E., Gould, T. W., Bail, R., Toumpaniari, S., Harrington, H., Dixon, J. E., Shakesheff, K. M., Segal, J., & Rose, F. R. A. J. (2014). A novel technique for the production of electrospun scaffolds with tailored three-dimensional micro-patterns employing additive manufacturing. Biofabrication, 6(3), 035003. https://doi.org/10.1088/1758-5082/6/3/035003

Electrospinning is a common technique used to fabricate fibrous scaffolds for tissue engineering applications. There is now growing interest in assessing the ability of collector plate design to influence the patterning of the fibres during the elect... Read More about A novel technique for the production of electrospun scaffolds with tailored three-dimensional micro-patterns employing additive manufacturing.

Immunocompetent 3D model of human upper airway for disease modeling and in vitro drug evaluation (2014)
Journal Article
Harrington, H., Cato, P., Salazar, F., Wilkinson, M., Knox, A., Haycock, J. W., Rose, F., Aylott, J. W., & Ghaemmaghami, A. M. (2014). Immunocompetent 3D model of human upper airway for disease modeling and in vitro drug evaluation. Molecular Pharmaceutics, 11(7), 2082-2091. https://doi.org/10.1021/mp5000295

The development of more complex in vitro models for the assessment of novel drugs and chemicals is needed because of the limited biological relevance of animal models to humans as well as ethical considerations. Although some human-cell-based assays... Read More about Immunocompetent 3D model of human upper airway for disease modeling and in vitro drug evaluation.

Self-reporting Scaffolds for 3-Dimensional Cell Culture (2013)
Journal Article
Harrington, H., Rose, F. R., Aylott, J. W., & Ghaemmaghami, A. M. (2013). Self-reporting Scaffolds for 3-Dimensional Cell Culture. Journal of Visualized Experiments, https://doi.org/10.3791/50608

Culturing cells in 3D on appropriate scaffolds is thought to better mimic the in vivo microenvironment and increase cell-cell interactions. The resulting 3D cellular construct can often be more relevant to studying the molecular events and cell-cell... Read More about Self-reporting Scaffolds for 3-Dimensional Cell Culture.

Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix (2013)
Journal Article
Rahman, C. V., Smith, S. J., Morgan, P. S., Langmack, K. A., Clarke, P. A., Ritchie, A. A., Macarthur, D. C., Rose, F. R., Shakesheff, K. M., Grundy, R. G., & Rahman, R. (2013). Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix. PLoS ONE, 8(10), Article e77435. https://doi.org/10.1371/journal.pone.0077435

INTRODUCTION

Polymer-based delivery systems offer innovative intra-cavity administration of drugs, with the potential to better target micro-deposits of cancer cells in brain parenchyma beyond the resected cavity. Here we evaluate clinical utility... Read More about Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix.

Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution (2013)
Journal Article
Reinwald, Y., Johal, R. K., Ghaemmaghami, A. M., Rose, F. R., Howdle, S. M., & Shakesheff, K. M. (2014). Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution. Polymer, 55(1), 435-444. https://doi.org/10.1016/j.polymer.2013.09.041

This study aims to investigate interconnectivity and permeability of scCO2-foamed scaffolds and the influence of structural scaffold properties on cell distribution. Supercritical fluid technology was utilized to fabricated scaffolds from 37 kDa, 53... Read More about Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution.

Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition (2012)
Journal Article
Smith, S. J., Wilson, M., Ward, J. H., Rahman, C. V., Peet, A. C., Macarthur, D. C., Rose, F. R., Grundy, R. G., & Rahman, R. (2012). Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition. PLoS ONE, 7(12), Article e52335. https://doi.org/10.1371/journal.pone.0052335

INTRODUCTION

Physiologically relevant pre-clinical ex vivo models recapitulating CNS tumor micro-environmental complexity will aid development of biologically-targeted agents. We present comprehensive characterization of tumor aggregates generated... Read More about Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition.