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3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review

Prina, Elisabetta; Mistry, Pritesh; Sidney, Laura E.; Yang, Jing; Wildman, Ricky D.; Bertolin, Marina; Breda, Claudia; Ferrari, Barbara; Barbaro, Vanessa; Hopkinson, Andrew; Dua, Harminder S.; Ferrari, Stefano; Rose, Felicity R A.J.

Authors

Elisabetta Prina

Pritesh Mistry

Laura E. Sidney

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JING YANG jing.yang@nottingham.ac.uk
Assistant Professor

Ricky D. Wildman

Marina Bertolin

Claudia Breda

Barbara Ferrari

Vanessa Barbaro

Andrew Hopkinson

Harminder S. Dua

Stefano Ferrari

Felicity R A.J. Rose



Abstract

In recent years, there has been increased research interest in generating corneal substitutes, either for use in the clinic or as in vitro corneal models. The advancement of 3D microfabrication technologies has allowed the reconstruction of the native microarchitecture that controls epithelial cell adhesion, migration and differentiation. In addition, such technology has allowed the inclusion of a dynamic fluid flow that better mimics the physiology of the native cornea. We review the latest innovative products in development in this field, from 3D microfabricated hydrogels to microfluidic devices.

Journal Article Type Article
Publication Date 2017-06
Journal Stem Cell Reviews and Reports
Print ISSN 1550-8943
Electronic ISSN 1558-6804
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 13
Issue 3
Pages 430-441
APA6 Citation Rose, F. R. A. J., Prina, E., Mistry, P., Sidney, L. E., Yang, J., Wildman, R. D., …Rose, F. R. A. (2017). 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review. Stem Cell Reviews and Reports, 13(3), 430-441. https://doi.org/10.1007/s12015-017-9740-6
DOI https://doi.org/10.1007/s12015-017-9740-6
Keywords Cornea, topography, microfabrication, 3D model, microfluidics
Publisher URL https://link.springer.com/article/10.1007%2Fs12015-017-9740-6
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information The final publication is available at Springer via http://dx.doi.org/10.1007/s12015-017-9740-6.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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