3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review

Prina, Elisabetta; Mistry, Pritesh; Sidney, Laura E.; Yang, Jing; Wildman, Ricky D.; Bertolin, Marina; Breda, Claudia; Ferrari, Barbara; Barbaro, Vanessa; Hopkinson, Andrew; Dua, Harminder S.; Ferrari, Stefano; Rose, Felicity R A.J.

Abstract

In recent years, there has been increased research interest in generating corneal substitutes, either for use in the clinic or as in vitro corneal models. The advancement of 3D microfabrication technologies has allowed the reconstruction of the native microarchitecture that controls epithelial cell adhesion, migration and differentiation. In addition, such technology has allowed the inclusion of a dynamic fluid flow that better mimics the physiology of the native cornea. We review the latest innovative products in development in this field, from 3D microfabricated hydrogels to microfluidic devices.

Citation

Prina, E., Mistry, P., Sidney, L. E., Yang, J., Wildman, R. D., Bertolin, M., Breda, C., Ferrari, B., Barbaro, V., Hopkinson, A., Dua, H. S., Ferrari, S., & Rose, F. R. A. (2017). 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review. Stem Cell Reviews and Reports, 13(3), 430-441. https://doi.org/10.1007/s12015-017-9740-6

• Journal Article Type: Article
• Acceptance Date: Jun 1, 2017
• Online Publication Date: Jun 1, 2017
• Publication Date: 2017-06
• Deposit Date: Jun 12, 2017
• Publicly Available Date: Jun 12, 2017
• Journal: Stem Cell Reviews and Reports
• Print ISSN: 1550-8943
• Electronic ISSN: 1558-6804
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 3
• Pages: 430-441
• DOI: https://doi.org/10.1007/s12015-017-9740-6
• Keywords: Cornea, topography, microfabrication, 3D model, microfluidics
• Public URL: https://nottingham-repository.worktribe.com/output/863343
• Publisher URL: https://link.springer.com/article/10.1007%2Fs12015-017-9740-6
• Additional Information: The final publication is available at Springer via http://dx.doi.org/10.1007/s12015-017-9740-6.
• Contract Date: Jun 12, 2017