All Outputs (8)

Disruption of Epithelial Barriers for Molecular Delivery Enhancement or Extraction of Extracellular Fluids (2024)
Patent
Webb, K., Moradi, E., & Foss, A. (2024). Disruption of Epithelial Barriers for Molecular Delivery Enhancement or Extraction of Extracellular Fluids. WO2024009101A1. UK

The invention provides a method of delivering a payload molecule across an epithelial tissue barrier, the method comprising: applying the payload molecule to the epithelial tissue barrier, and additionally applying an agent to the epithelial tissue b... Read More about Disruption of Epithelial Barriers for Molecular Delivery Enhancement or Extraction of Extracellular Fluids.

Picosecond ultrasonics for elasticity-based imaging and characterization of biological cells (2020)
Journal Article
Pérez-Cota, F., Fuentes-Domínguez, R., La Cavera III, S., Hardiman, W., Yao, M., Setchfield, K., …Clark, M. (2020). Picosecond ultrasonics for elasticity-based imaging and characterization of biological cells. Journal of Applied Physics, 128(16), Article 160902. https://doi.org/10.1063/5.0023744

© 2020 Author(s). Characterization of the elasticity of biological cells is growing as a new way to gain insight into cell biology. Cell mechanics are related to most aspects of cellular behavior, and applications in research and medicine are broad.... Read More about Picosecond ultrasonics for elasticity-based imaging and characterization of biological cells.

Label-free, high resolution, multi-modal light microscopy for discrimination of live stem cell differentiation status (2018)
Journal Article
Zhang, J., Moradi, E., Somekh, M. G., & Mather, M. L. (2018). Label-free, high resolution, multi-modal light microscopy for discrimination of live stem cell differentiation status. Scientific Reports, 8(1), Article 697. https://doi.org/10.1038/s41598-017-18714-y

A label-free microscopy method for assessing the differentiation status of stem cells is presented with potential application for characterization of therapeutic stem cell populations. The microscopy system is capable of characterizing live cells bas... Read More about Label-free, high resolution, multi-modal light microscopy for discrimination of live stem cell differentiation status.

Cell imaging by phonon microscopy: sub-optical wavelength ultrasound for non-invasive imaging (2017)
Journal Article
Perez-Cota, F., Smith, R. J., Moradi, E., Leija, A. L., Velickovic, K., Marques, L., …Clark, M. (2017). Cell imaging by phonon microscopy: sub-optical wavelength ultrasound for non-invasive imaging

The mechanical properties of cells play an important role in cell function and behavior. This paper presents recent developments that have enabled the use of laser-generated phonons (ultrasound) with sub-optical wavelengths to look inside living cell... Read More about Cell imaging by phonon microscopy: sub-optical wavelength ultrasound for non-invasive imaging.

High resolution 3D imaging of living cells with sub-optical wavelength phonons (2016)
Journal Article
Perez-Cota, F., Smith, R. J., Moradi, E., Marques, L., Webb, K. F., & Clark, M. (2016). High resolution 3D imaging of living cells with sub-optical wavelength phonons. Scientific Reports, 6, Article 39326. https://doi.org/10.1038/srep39326

Label-free imaging of living cells below the optical diffraction limit poses great challenges for optical microscopy. Biologically relevant structural information remains below the Rayleigh limit and beyond the reach of conventional microscopes. Supe... Read More about High resolution 3D imaging of living cells with sub-optical wavelength phonons.

Thin-film transducers for the detection and imaging of Brillouin oscillations in transmission on cultured cells (2015)
Journal Article
Perez-Cota, F., Smith, R. J., Moradi, E., Webb, K. F., & Clark, M. (in press). Thin-film transducers for the detection and imaging of Brillouin oscillations in transmission on cultured cells. Journal of Physics: Conference Series, 684(1), https://doi.org/10.1088/1742-6596/684/1/012003

Mechanical imaging and characterisation of biological cells has been a subject of interest for the last twenty years. Ultrasonic imaging based on the scanning acoustic microscope (SAM) and mechanical probing have been extensively reported. Large acou... Read More about Thin-film transducers for the detection and imaging of Brillouin oscillations in transmission on cultured cells.

Thin-film optoacoustic transducers for the subcellular Brillouin oscillation imaging of individual biological cells (2015)
Journal Article
Perez-Cota, F., Smith, R. J., Moradi, E., Marques, L., Webb, K. F., & Clark, M. (2015). Thin-film optoacoustic transducers for the subcellular Brillouin oscillation imaging of individual biological cells. Applied Optics, 54(28), https://doi.org/10.1364/AO.54.008388

Mechanical characterisation and imaging of biological tissue has piqued interest in the applicability to cell and tissue biology. One method, based on detection of Brillouin oscillations, has already lead to demonstrations on biological cells using u... Read More about Thin-film optoacoustic transducers for the subcellular Brillouin oscillation imaging of individual biological cells.

Sub-100 nm resolution microscopy based on proximity projection grating scheme (2015)
Journal Article
Hu, F., Somekh, M. G., Albutt, D. J., Webb, K., Moradi, E., & See, C. W. (2015). Sub-100 nm resolution microscopy based on proximity projection grating scheme. Scientific Reports, 5, https://doi.org/10.1038/srep08589

Structured illumination microscopy (SIM) has been widely used in life science imaging applications. The maximum resolution improvement of SIM, compared to conventional bright field system is a factor of 2. Here we present an approach to structured il... Read More about Sub-100 nm resolution microscopy based on proximity projection grating scheme.