FERNANDO PEREZ-COTA FERNANDO.PEREZ-COTA@NOTTINGHAM.AC.UK
Assistant Professor
Picosecond ultrasonics for elasticity-based imaging and characterization of biological cells
P�rez-Cota, Fernando; Fuentes-Dom�nguez, Rafael; La Cavera III, Salvatore; Hardiman, William; Yao, Mengting; Setchfield, Kerry; Moradi, Emilia; Naznin, Shakila; Wright, Amanda; Webb, Kevin F.; Huett, Alan; Friel, Claire; Sottile, Virginie; Elsheikha, Hany M.; Smith, Richard J.; Clark, Matt
Authors
RAFAEL FUENTES DOMINGUEZ RAFAEL.FUENTESDOMINGUEZ1@NOTTINGHAM.AC.UK
Research Fellow
Salvatore La Cavera III
William Hardiman
Mengting Yao
Kerry Setchfield
Emilia Moradi
Shakila Naznin
AMANDA WRIGHT Amanda.Wright@nottingham.ac.uk
Professor of Optics
Dr KEVIN WEBB KEVIN.WEBB@NOTTINGHAM.AC.UK
Associate Professor
ALAN HUETT Alan.Huett@nottingham.ac.uk
Assistant Professor
CLAIRE FRIEL Claire.Friel@nottingham.ac.uk
Assistant Professor
Virginie Sottile
Professor HANY ELSHEIKHA hany.elsheikha@nottingham.ac.uk
Professor of Interdisciplinary Parasitology
RICHARD SMITH RICHARD.J.SMITH@NOTTINGHAM.AC.UK
Associate Professor
MATT CLARK matt.clark@nottingham.ac.uk
Professor of Applied Optics
Abstract
© 2020 Author(s). Characterization of the elasticity of biological cells is growing as a new way to gain insight into cell biology. Cell mechanics are related to most aspects of cellular behavior, and applications in research and medicine are broad. Current methods are often limited since they require physical contact or lack resolution. From the methods available for the characterization of elasticity, those relying on high frequency ultrasound (phonons) are the most promising because they offer label-free, high (even super-optical) resolution and compatibility with conventional optical microscopes. In this Perspective contribution, we review the state of the art of picosecond ultrasonics for cell imaging and characterization, particularly for Brillouin scattering-based methods, offering an opinion for the challenges faced by the technology. The challenges are separated into biocompatibility, acquisition speed, resolution, and data interpretation and are discussed in detail along with new results.
Citation
Pérez-Cota, F., Fuentes-Domínguez, R., La Cavera III, S., Hardiman, W., Yao, M., Setchfield, K., …Clark, M. (2020). Picosecond ultrasonics for elasticity-based imaging and characterization of biological cells. Journal of Applied Physics, 128(16), Article 160902. https://doi.org/10.1063/5.0023744
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 8, 2020 |
Online Publication Date | Oct 28, 2020 |
Publication Date | Oct 28, 2020 |
Deposit Date | Oct 19, 2020 |
Publicly Available Date | Oct 28, 2020 |
Journal | Journal of Applied Physics |
Print ISSN | 0021-8979 |
Electronic ISSN | 1089-7550 |
Publisher | American Institute of Physics |
Peer Reviewed | Peer Reviewed |
Volume | 128 |
Issue | 16 |
Article Number | 160902 |
DOI | https://doi.org/10.1063/5.0023744 |
Public URL | https://nottingham-repository.worktribe.com/output/4968913 |
Publisher URL | https://aip.scitation.org/doi/10.1063/5.0023744 |
Files
Picosecond Cell Imaging
(5.9 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
You might also like
Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors
(2020)
Journal Article
Combinatorial actions of bacterial effectors revealed by exploiting genetic tools in yeast
(2017)
Journal Article
Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling
(2012)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: digital-library-support@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search