Skip to main content

Research Repository

Advanced Search

All Outputs (214)

Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex (2019)
Journal Article
Qu, Y., Hahn, I., Lees, M., Parkin, J., Voelzmann, A., Dorey, K., …Prokop, A. (2019). Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex. eLife, 8, Article e50319. https://doi.org/10.7554/elife.50319

© 2019, Qu et al. Cortical collapse factors affect microtubule (MT) dynamics at the plasma membrane. They play important roles in neurons, as suggested by inhibition of axon growth and regeneration through the ARF activator Efa6 in C. elegans, and by... Read More about Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex.

LC-MS metabolomics comparisons of cancer cell and macrophage responses to methotrexate and polymer-encapsulated methotrexate (2019)
Journal Article
Al-Natour, M. A., Alazzo, A., Ghaemmaghami, A. M., Kim, D., & Alexander, C. (2019). LC-MS metabolomics comparisons of cancer cell and macrophage responses to methotrexate and polymer-encapsulated methotrexate. International Journal of Pharmaceutics: X, 1, Article 100036. https://doi.org/10.1016/j.ijpx.2019.100036

Methotrexate (MTX) is a folate analogue antimetabolite widely used for the treatment of rheumatoid arthritis and cancer. A number of studies have shown that MTX delivered via nanoparticle carriers is more potent against cancer cells than free MTX, a... Read More about LC-MS metabolomics comparisons of cancer cell and macrophage responses to methotrexate and polymer-encapsulated methotrexate.

Hmgcr promotes a long-range signal to attract Drosophila germ cells independently of Hedgehog (2019)
Journal Article
Kenwrick, K., Mukherjee, A., & Renault, A. D. (2019). Hmgcr promotes a long-range signal to attract Drosophila germ cells independently of Hedgehog. Journal of Cell Science, 132(23), 1-14. https://doi.org/10.1242/jcs.232637

During development many cell types migrate along stereotyped routes determined through deployment of cell surface or secreted guidance molecules. Whilst we know the identity of many of these molecules, the distances over which they natively operate c... Read More about Hmgcr promotes a long-range signal to attract Drosophila germ cells independently of Hedgehog.

Life-threatening hypersensitivity pneumonitis secondary to e-cigarettes (2019)
Journal Article
Nair, N., Hurley, M., Gates, S., Davies, P., Chen, I. L., Todd, I., …Bhatt, M. (2020). Life-threatening hypersensitivity pneumonitis secondary to e-cigarettes. Archives of Disease in Childhood, 105(11), 1114-1116. https://doi.org/10.1136/archdischild-2019-317889

© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. We report a case of hypersensitivity pneumonitis (HP) in a young person secondary to vaping. He presented with a putative diagnosis of asthma... Read More about Life-threatening hypersensitivity pneumonitis secondary to e-cigarettes.

Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells (2019)
Journal Article
Quilles Junior, J. C., Bradshaw, T. D., Turyanska, L., Carlos, F. D. R. R., Montanari, A., Leitão, A., …Bradshaw, T. D. (2019). Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells. RSC Advances, 9(63), 36699-36706. https://doi.org/10.1039/c9ra07161j

Cysteine proteases play a key role in tumorigenesis causing protein degradation and promoting invasive tumour growth. Cathepsin L is overexpressed in cancer cells and could provide a specific target for delivery of anticancer agents. We encapsulated... Read More about Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells.

Whole-body and adipose tissue-specific mechanisms underlying the metabolic effects of fibroblast growth factor 21 in the Siberian hamster (2019)
Journal Article
Lewis, J. E., Monnier, C., Marshall, H., Fowler, M., Green, R., Cooper, S., …Tsintzas, K. (2020). Whole-body and adipose tissue-specific mechanisms underlying the metabolic effects of fibroblast growth factor 21 in the Siberian hamster. Molecular Metabolism, 31, 45-54. https://doi.org/10.1016/j.molmet.2019.10.009

Objective Fibroblast growth factor 21 (FGF21) has been shown to rapidly lower body weight in the Siberian hamster, a preclinical model of adiposity. This induced negative energy balance mediated by FGF21 is associated with both lowered caloric intak... Read More about Whole-body and adipose tissue-specific mechanisms underlying the metabolic effects of fibroblast growth factor 21 in the Siberian hamster.

A new framework for characterization of poroelastic materials using indentation (2019)
Journal Article
Esteki, M. H., Alemrajabi, A. A., Hall, C., Sheridan, G. K., Azadi, M., & Moeendarbary, E. (2020). A new framework for characterization of poroelastic materials using indentation. Acta Biomaterialia, 102, 138-148. https://doi.org/10.1016/j.actbio.2019.11.010

To characterize a poroelastic material, typically an indenter is pressed onto the surface of the material with a ramp of a finite approach velocity followed by a hold where the indenter displacement is kept constant. This leads to deformation of the... Read More about A new framework for characterization of poroelastic materials using indentation.

Prognostic Significance of KN Motif and Ankyrin Repeat Domains 1 (KANK1) in Invasive Breast Cancer (2019)
Journal Article
Kariri, Y. A., Joseph, C., Kurozumi, S., Toss, M. S., Alsaleem, M., Raafat, S., …Rakha, E. A. (2020). Prognostic Significance of KN Motif and Ankyrin Repeat Domains 1 (KANK1) in Invasive Breast Cancer. Breast Cancer Research and Treatment, 179(2), 349–357. https://doi.org/10.1007/s10549-019-05466-8

Background: KN Motif and Ankyrin Repeat Domains 1 (KANK1) plays an important role in cytoskeleton maintenance and contributes to the regulation of cell proliferation, adhesion and apoptosis. KANK1 is involved in progression of a variety of solid tumo... Read More about Prognostic Significance of KN Motif and Ankyrin Repeat Domains 1 (KANK1) in Invasive Breast Cancer.

Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis (2019)
Journal Article
Webb, K., Fogarty, A., Barrett, D. A., Nash, E. F., Whitehouse, J. L., Smyth, A. R., …Cámara, M. (2019). Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis. Journal of Medical Microbiology, 68(12), 1823-1828. https://doi.org/10.1099/jmm.0.001099

Introduction : Pseudomonas aeruginosa is an important respiratory pathogen in cystic fibrosis (CF), which is associated with an accelerated decline in lung function, frequent pulmonary exacerbations and increased mortality. P. aeruginosa produces in... Read More about Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis.

Cetuximab-conjugated chitosan-pectinate (modified) composite nanoparticles for targeting colon cancer (2019)
Journal Article
Sabra, R., Billa, N., & Roberts, C. J. (2019). Cetuximab-conjugated chitosan-pectinate (modified) composite nanoparticles for targeting colon cancer. International Journal of Pharmaceutics, 572, Article 118775. https://doi.org/10.1016/j.ijpharm.2019.118775

© 2019 Elsevier B.V. In the present study, we successfully developed a cetuximab-conjugated modified citrus pectin-chitosan nanoparticles for targeted delivery of curcumin (Cet-MCPCNPs) for the treatment of colorectal cancer. In vitro analyses reveal... Read More about Cetuximab-conjugated chitosan-pectinate (modified) composite nanoparticles for targeting colon cancer.

Extinction risk and conservation gaps for Aloe (Asphodelaceae) in the Horn of Africa (2019)
Journal Article
Bachman, S. P., Wilkin, P., Reader, T., Field, R., Weber, O., Nordal, I., & Demissew, S. (2020). Extinction risk and conservation gaps for Aloe (Asphodelaceae) in the Horn of Africa. Biodiversity and Conservation, 29(1), 77–98. https://doi.org/10.1007/s10531-019-01870-0

Identification of conservation priorities is essential for conservation planning, especially as the biodiversity crisis develops. We aimed to support conservation prioritisation by addressing knowledge gaps for the genus Aloe in the Horn of Africa. S... Read More about Extinction risk and conservation gaps for Aloe (Asphodelaceae) in the Horn of Africa.

Chronic effects of high-intensity interval training on postprandial lipemia in healthy men (2019)
Journal Article
Wilhelmsen, A. J., Tsintzas, K., Mallinson, J., Jones, R., Cooper, S., & Taylor, T. (2019). Chronic effects of high-intensity interval training on postprandial lipemia in healthy men. Journal of Applied Physiology, 127(6), 1763-1771. https://doi.org/10.1152/japplphysiol.00131.2019

The aim of this study was to determine thechronic (≥72h post-exercise) effects of high intensity interval training (HIIT) on postprandial lipaemia and metabolic markers in healthy volunteers. Eight physically active young males (Mean ± SD: age 22 ± 3... Read More about Chronic effects of high-intensity interval training on postprandial lipemia in healthy men.

Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection (2019)
Journal Article
Kulcsar, K. A., Coleman, C. M., Beck, S. E., & Frieman, M. B. (2019). Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection. JCI insight, 4(20), 1-18. https://doi.org/10.1172/jci.insight.131774

Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 in Saudi Arabia and has caused over 2400 cases and more than 800 deaths. Epidemiological studies identified diabetes as the primary comorbidity associated with severe or lethal M... Read More about Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection.

Comparative Docking to Distinct G Protein–Coupled Receptor Conformations Exclusively Yields Ligands with Agonist Efficacy (2019)
Journal Article
Scharf, M. M., Bünemann, M., Baker, J. G., & Kolb, P. (2019). Comparative Docking to Distinct G Protein–Coupled Receptor Conformations Exclusively Yields Ligands with Agonist Efficacy. Molecular Pharmacology, 96(6), 851-861. https://doi.org/10.1124/mol.119.117515

G protein-coupled receptors exist in a whole spectrum of conformations which are stabilised by the binding of ligands with different efficacy or intracellular effector proteins. Here, we investigate whether three-dimensional structures of receptor co... Read More about Comparative Docking to Distinct G Protein–Coupled Receptor Conformations Exclusively Yields Ligands with Agonist Efficacy.

A randomized, controlled, double-blind crossover study on the effects of isoeffective and isovolumetric intravenous crystalloid and gelatin on blood volume, and renal and cardiac hemodynamics (2019)
Journal Article
Bradley, C. R., Bragg, D. D., Cox, E. F., El-Sharkawy, A. M., Buchanan, C. E., Chowdhury, A. H., …Lobo, D. N. (2020). A randomized, controlled, double-blind crossover study on the effects of isoeffective and isovolumetric intravenous crystalloid and gelatin on blood volume, and renal and cardiac hemodynamics. Clinical Nutrition, 39(7), 2070-2079. https://doi.org/10.1016/j.clnu.2019.09.011

Background & aims Blood volume expanding properties of colloids are superior to crystalloids. In addition to oncotic/osmotic properties, the electrolyte composition of infusions may have important effects on visceral perfusion, with infusions contai... Read More about A randomized, controlled, double-blind crossover study on the effects of isoeffective and isovolumetric intravenous crystalloid and gelatin on blood volume, and renal and cardiac hemodynamics.

Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model (2019)
Journal Article
Costa-Marques, L., Arnold, K., Pardon, M. C., Leovsky, C., Swarbrick, S., Fabian, C., & Stolzing, A. (2019). Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model. Translational Neurodegeneration, 8, Article 33. https://doi.org/10.1186/s40035-019-0173-9

© 2019 The Author(s). Background: We investigated early hallmarks of putative therapeutic effects following systemic transplantation of bone marrow derived macrophages (BM-M) in APP/PS1 transgenic mice. Method: BM-M were transplanted into the tail ve... Read More about Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model.

Computer Tomography-Based Psoas Skeletal Muscle Area and Radiodensity are Poor Sentinels for Whole L3 Skeletal Muscle Values (2019)
Journal Article
Rollins, K. E., Gopinath, A., Awwad, A., Macdonald, I. A., & Lobo, D. N. (2020). Computer Tomography-Based Psoas Skeletal Muscle Area and Radiodensity are Poor Sentinels for Whole L3 Skeletal Muscle Values. Clinical Nutrition, 39(7), 2227-2232. https://doi.org/10.1016/j.clnu.2019.10.003

Background and aims Computed tomography (CT)-based measurement of skeletal muscle cross-sectional area (CSA) and Hounsfield unit (HU) radiodensity are used to assess the presence of sarcopenia and myosteatosis, respectively. The validated CT-based t... Read More about Computer Tomography-Based Psoas Skeletal Muscle Area and Radiodensity are Poor Sentinels for Whole L3 Skeletal Muscle Values.