Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model

Costa-Marques, Lu�s; Arnold, Katrin; Pardon, Marie Christine; Leovsky, Christiane; Swarbrick, Samantha; Fabian, Claire; Stolzing, Alexandra

Abstract

© 2019 The Author(s). Background: We investigated early hallmarks of putative therapeutic effects following systemic transplantation of bone marrow derived macrophages (BM-M) in APP/PS1 transgenic mice. Method: BM-M were transplanted into the tail vein and the animals analysed 1 month later. Results: BM-M transplantation promoted the reduction of the amyloid beta [37-42] plaque number and size in the cortex and hippocampus of the treated mice, but no change in the more heavily modified pyroglutamate amyloid beta E3 plaques. The number of phenotypically 'small' microglia increased in the hippocampus. Astrocyte size decreased overall, indicating a reduction of activated astrocytes. Gene expression of interleukin 6 and 10, interferon-gamma, and prostaglandin E receptor 2 was significantly lower in the hippocampus, while interleukin 10 expression was elevated in the cortex of the treated mice. Conclusions: BM-M systemically transplanted, promote a decrease in neuroinflammation and a limited reversion of amyloid pathology. This exploratory study may support the potential of BM-M or microglia-like cell therapy and further illuminates the mechanisms of action associated with such transplants.

Citation

Costa-Marques, L., Arnold, K., Pardon, M. C., Leovsky, C., Swarbrick, S., Fabian, C., & Stolzing, A. (2019). Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model. Translational Neurodegeneration, 8, Article 33. https://doi.org/10.1186/s40035-019-0173-9

• Journal Article Type: Article
• Acceptance Date: Oct 10, 2019
• Online Publication Date: Oct 14, 2019
• Publication Date: Oct 14, 2019
• Deposit Date: Feb 17, 2020
• Publicly Available Date: Mar 3, 2020
• Journal: Translational Neurodegeneration
• Electronic ISSN: 2047-9158
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 8
• Article Number: 33
• DOI: https://doi.org/10.1186/s40035-019-0173-9
• Public URL: https://nottingham-repository.worktribe.com/output/3132094
• Publisher URL: https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-019-0173-9