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Prognostic Significance of KN Motif and Ankyrin Repeat Domains 1 (KANK1) in Invasive Breast Cancer

Kariri, Yousif A; Joseph, Chitra; Kurozumi, Sasagu; Toss, Michael S; Alsaleem, Mansour; Raafat, Sara; Mongan, Nigel P; Aleskandarany, Mohammed A; Green, Andrew R; Rakha, Emad A

Authors

Yousif A Kariri

Chitra Joseph

Sasagu Kurozumi

Mansour Alsaleem

Sara Raafat

Nigel P Mongan

Andrew R Green

Emad A Rakha



Abstract

Background: KN Motif and Ankyrin Repeat Domains 1 (KANK1) plays an important role in cytoskeleton maintenance and contributes to the regulation of cell proliferation, adhesion and apoptosis. KANK1 is involved in progression of a variety of solid tumours, however, its role in invasive breast cancer (BC) remains unknown. This study aims to evaluate the clinicopathological and prognostic value of KANK1 expression in operable BC.
Methods: KANK1 expression was assessed at the transcriptomic level using multiple BC cohorts; the Molecular Taxonomy of BC International Consortium cohort (METABRIC; n=1980), The Cancer Genome Atlas BC cohort (TCGA; n=949) and the publicly available BC transcriptomic data hosted by BC Gene-Expression Miner (bc- GenExMiner v4.0) and Kaplan Meier-plotter?. The Nottingham BC cohort (n=1500) prepared as tissue microarrays was used to assess KANK1 protein expression using immunohistochemistry (IHC). The association between clinicopathological variables and patient outcome was investigated.
Results: In the METABRIC cohort, high expression of KANK1 mRNA was associated with characteristics of good prognosis including lower grade, absence of lymphovascular invasion and HER2 negativity (all; p

Journal Article Type Article
Publication Date Nov 2, 2019
Print ISSN 0167-6806
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Institution Citation Kariri, Y. A., Joseph, C., Kurozumi, S., Toss, M. S., Alsaleem, M., Raafat, S., …Rakha, E. A. (2019). Prognostic Significance of KN Motif and Ankyrin Repeat Domains 1 (KANK1) in Invasive Breast Cancer. Breast Cancer Research and Treatment, https://doi.org/10.1007/s10549-019-05466-8
DOI https://doi.org/10.1007/s10549-019-05466-8
Publisher URL https://link.springer.com/article/10.1007%2Fs10549-019-05466-8

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