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Chronic effects of high-intensity interval training on postprandial lipemia in healthy men

Wilhelmsen, Andrew John; Tsintzas, Kostas; Mallinson, Joanne; Jones, Robert; Cooper, Scott; Taylor, Tariq

Authors

Andrew John Wilhelmsen

Joanne Mallinson

Robert Jones

Scott Cooper

Tariq Taylor



Abstract

The aim of this study was to determine thechronic (≥72h post-exercise) effects of high intensity interval training (HIIT) on postprandial lipaemia and metabolic markers in healthy volunteers. Eight physically active young males (Mean ± SD: age 22 ± 3years, height 1.77 ± 0.07m, body mass 67.7 ± 6.2kg) underwent two 6h mixed-meal tolerance tests and resting vastus lateralis muscle biopsies, before the first- and ≥72h after the final-session of four weeks of HIIT (16 sessions in total; 10x60s bouts of cycling at 90% maximal oxygen uptake [V̇O2max], interspersed by 60s intervals at 45% V̇O2max). Arterialised and deep venous blood samples across the forearm, brachial artery blood flow measurements, and whole-body indirect calorimetry data were obtained before, and at regular intervals for 6h after, consumption of a standardised mixed-meal. The main findings revealed that, when assessed ≥72h post-exercise, postprandial free fatty acid (FFA) uptake across the forearm was increased in response to exercise training (P= 0.025). However, four weeks of HIIT did not alter fasting or postprandial circulating triglyceride (TAG) concentrations, or their tissue uptake, despite a 10.2 ± 7.7% improvement in V̇O2max(P= 0.004). Protein content of adipose triglyceride lipase (ATGL) in the vastus lateralis at rest was reduced by 25 ± 21% (P= 0.01). Collectively, these findings suggest that 4 weeks of HITT enhances postprandial clearance of FFA, when assessed ≥72h post-exercise, but does not confer persisting (training) adaptations in postprandial triglyceridaemia.

Citation

Wilhelmsen, A. J., Tsintzas, K., Mallinson, J., Jones, R., Cooper, S., & Taylor, T. (2019). Chronic effects of high-intensity interval training on postprandial lipemia in healthy men. Journal of Applied Physiology, 127(6), 1763-1771. https://doi.org/10.1152/japplphysiol.00131.2019

Journal Article Type Article
Acceptance Date Oct 12, 2019
Online Publication Date Oct 17, 2019
Publication Date Dec 1, 2019
Deposit Date Nov 19, 2019
Publicly Available Date Oct 18, 2020
Journal Journal of Applied Physiology
Print ISSN 8750-7587
Electronic ISSN 1522-1601
Publisher American Physiological Society
Peer Reviewed Peer Reviewed
Volume 127
Issue 6
Pages 1763-1771
DOI https://doi.org/10.1152/japplphysiol.00131.2019
Keywords Physiology (medical); Physiology
Public URL https://nottingham-repository.worktribe.com/output/3331566
Publisher URL https://www.physiology.org/doi/abs/10.1152/japplphysiol.00131.2019