Skip to main content

Research Repository

Advanced Search

All Outputs (203)

Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain (2017)
Journal Article
Lewis, J. E., Brameld, J. M., Hill, P., Cocco, C., Noli, B., Ferri, G., …Jethwa, P. (2017). Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain. PLoS ONE, 12, Article e01727. https://doi.org/10.1371/journal.pone.0172724

VGF (non-acronymic) was first highlighted to have a role in energy homeostasis through experiments involving dietary manipulation in mice. Fasting increased VGF mRNA in the Arc and levels were subsequently reduced upon refeeding. This anabolic role f... Read More about Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain.

Effects of short-term energy restriction on liver lipid content and inflammatory status in severely obese adults: results of a randomised controlled trial (RCT) using two dietary approaches (2017)
Journal Article
Baldry, E., Aithal, G. P., Kaye, P., Idris, I., Bennett, A., Leeder, P. C., & MacDonald, I. A. (2017). Effects of short-term energy restriction on liver lipid content and inflammatory status in severely obese adults: results of a randomised controlled trial (RCT) using two dietary approaches. Diabetes, Obesity and Metabolism, 19(8), https://doi.org/10.1111/dom.12918

Short-term very low energy diets (VLED) are used in clinical practice prior to bariatric surgery, however, regimens vary and outcomes for a short intervention are unclear. We examined the effect of two VLEDs; a food-based diet (FD) and meal replaceme... Read More about Effects of short-term energy restriction on liver lipid content and inflammatory status in severely obese adults: results of a randomised controlled trial (RCT) using two dietary approaches.

Identification of a Pseudomonas aeruginosa PAO1 DNA methyltransferase, its Targets, and physiological roles (2017)
Journal Article
Doberenz, S., Eckweiler, D., Reichert, O., Jensen, V., Bunk, B., Spröer, C., …Häussler, S. (2017). Identification of a Pseudomonas aeruginosa PAO1 DNA methyltransferase, its Targets, and physiological roles. mBio, 8(1), Article e02312-16. https://doi.org/10.1128/mBio.02312-16

DNA methylation is widespread among prokaryotes, and most DNA methylation reactions are catalyzed by adenine DNA methyltransferases, which are part of restriction-modification (R-M) systems. R-M systems are known for their role in the defense against... Read More about Identification of a Pseudomonas aeruginosa PAO1 DNA methyltransferase, its Targets, and physiological roles.

Application of carbohydrate arrays coupled with mass spectrometry to detect activity of plant-polysaccharide degradative enzymes from the fungus Aspergillus niger (2017)
Journal Article
van Munster, J. M., Thomas, B., Riese, M., Davis, A. L., Gray, C. J., Archer, D. B., & Flitsch, S. L. (in press). Application of carbohydrate arrays coupled with mass spectrometry to detect activity of plant-polysaccharide degradative enzymes from the fungus Aspergillus niger. Scientific Reports, 7(43117), https://doi.org/10.1038/srep43117

Renewables-based biotechnology depends on enzymes to degrade plant lignocellulose to simple sugars that are converted to fuels or high-value products. Identification and characterization of such lignocellulose degradative enzymes could be fast-tracke... Read More about Application of carbohydrate arrays coupled with mass spectrometry to detect activity of plant-polysaccharide degradative enzymes from the fungus Aspergillus niger.

Bacterial cell-to-cell signaling promotes the evolution of resistance to parasitic bacteriophages (2017)
Journal Article
Moreau, P., Diggle, S. P., & Friman, V. (2017). Bacterial cell-to-cell signaling promotes the evolution of resistance to parasitic bacteriophages. Ecology and Evolution, 7(6), https://doi.org/10.1002/ece3.2818

The evolution of host–parasite interactions could be affected by intraspecies variation between different host and parasite genotypes. Here we studied how bacterial host cell-to-cell signaling affects the interaction with parasites using two bacteria... Read More about Bacterial cell-to-cell signaling promotes the evolution of resistance to parasitic bacteriophages.

A pilot study to survey the carnivore community in the hyper-arid environment of South Sinai Mountains (2017)
Journal Article
Gecchele, L. V., Bremner-Harrison, S., Gilbert, F., Soultan, A. E., Davison, A., & Durrant, K. L. (2017). A pilot study to survey the carnivore community in the hyper-arid environment of South Sinai Mountains. Journal of Arid Environments, 141, https://doi.org/10.1016/j.jaridenv.2017.01.009

Carnivores are one of the taxa most affected by habitat fragmentation and human persecution; as a result, most carnivore species are declining; for this reason monitoring changes in carnivore population is paramount to plan effective conservation pro... Read More about A pilot study to survey the carnivore community in the hyper-arid environment of South Sinai Mountains.

Copy number variation of human AMY1 is a minor contributor to variation in salivary amylase expression and activity (2017)
Journal Article
Carpenter, D., Mitchell, L., & Armour, J. A. (2017). Copy number variation of human AMY1 is a minor contributor to variation in salivary amylase expression and activity. Human Genomics, 11, Article 2. https://doi.org/10.1186/s40246-017-0097-3

Background Salivary amylase in humans is encoded by the copy variable gene AMY1 in the amylase gene cluster on chromosome 1. Although the role of salivary amylase is well established, the consequences of the copy number variation (CNV) at AMY1 on... Read More about Copy number variation of human AMY1 is a minor contributor to variation in salivary amylase expression and activity.

Negative regulation of violacein biosynthesis in Chromobacterium violaceum (2017)
Journal Article
Devescovi, G., Kojic, M., Covaceuszach, S., Cámara, M., Williams, P., Bertani, I., …Venturi, V. (in press). Negative regulation of violacein biosynthesis in Chromobacterium violaceum. Frontiers in Microbiology, 8, Article 349. https://doi.org/10.3389/fmicb.2017.00349

In Chromobacteium violaceum, the purple pigment violacein is under positive regulation by the N-acylhomoserine lactone CviI/R quorum sensing system and negative regulation by an uncharacterized putative repressor. In this study we report that the bio... Read More about Negative regulation of violacein biosynthesis in Chromobacterium violaceum.

The genome landscape of indigenous African cattle (2017)
Journal Article
Kim, J., Hanotte, O., Okeyo, A. M., Dessie, T., Bashir, S., Diallo, B., …Kim, H. (2017). The genome landscape of indigenous African cattle. Genome Biology, 18(1), Article 34. https://doi.org/10.1186/s13059-017-1153-y

© 2017 The Author(s). Background: The history of African indigenous cattle and their adaptation to environmental and human selection pressure is at the root of their remarkable diversity. Characterization of this diversity is an essential step toward... Read More about The genome landscape of indigenous African cattle.

Endothelin-1 and its receptors on haemorrhoidal tissue: a potential site for therapeutic intervention (2017)
Journal Article
Lohsiriwat, V., Scholefield, J. H., Wilson, V. G., & Dashwood, M. R. (2017). Endothelin-1 and its receptors on haemorrhoidal tissue: a potential site for therapeutic intervention. British Journal of Pharmacology, 174(7), 569-579. https://doi.org/10.1111/bph.13719

© 2017 The British Pharmacological Society Background and Purpose: Haemorrhoids is a common anorectal condition affecting millions worldwide. We have studied the effect of endothelin-1 (ET-1) and the role of endothelin ETA and ETB receptors in haemor... Read More about Endothelin-1 and its receptors on haemorrhoidal tissue: a potential site for therapeutic intervention.

Mathematical modelling of clostridial acetone-butanol-ethanol fermentation (2017)
Journal Article
Millat, T., & Winzer, K. (in press). Mathematical modelling of clostridial acetone-butanol-ethanol fermentation. Applied Microbiology and Biotechnology, 101(6), https://doi.org/10.1007/s00253-017-8137-4

Clostridial acetone-butanol-ethanol (ABE) fermentation features a remarkable shift in the cellular metabolic activity from acid formation, acidogenesis, to the production of industrial-relevant solvents, solventogensis. In recent decades, mathematica... Read More about Mathematical modelling of clostridial acetone-butanol-ethanol fermentation.

Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus (2017)
Journal Article
Vries, R. P. D., Riley, R., Wiebenga, A., Aguilar-Osorio, G., Amillis, S., Akemi Uchima, C., …Grigoriev, I. V. (2017). Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus. Genome Biology, 18, Article 28. https://doi.org/10.1186/s13059-017-1151-0

Background: The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic contaminants of food, and an import... Read More about Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus.

Eda haplotypes in three-spined stickleback are associated with variation in immune gene expression (2017)
Journal Article
Robertson, S., Bradley, J. E., & MacColl, A. D. (in press). Eda haplotypes in three-spined stickleback are associated with variation in immune gene expression. Scientific Reports, 7, https://doi.org/10.1038/srep42677

Haplotypes underlying local adaptation and speciation are predicted to have numerous phenotypic effects, but few genes involved have been identified, with much work to date concentrating on visible, morphological, phenotypes. The link between genes c... Read More about Eda haplotypes in three-spined stickleback are associated with variation in immune gene expression.

ID4 levels dictate the stem cell state in mouse spermatogonia (2017)
Journal Article
Helsel, A. R., Yang, Q., Oatley, M., Lord, T., Sablitzky, F., & Oatley, J. M. (in press). ID4 levels dictate the stem cell state in mouse spermatogonia. Development, 144, https://doi.org/10.1242/dev.146928

Spermatogenesis is a classic model of cycling cell lineages that depend on a balance between stem cell self-renewal for continuity and the formation of progenitors as the initial step in the production of differentiated cells. The mechanisms that gui... Read More about ID4 levels dictate the stem cell state in mouse spermatogonia.

Metal-based combinations that target protein synthesis by fungi (2017)
Journal Article
Vallières, C., & Avery, S. V. (2017). Metal-based combinations that target protein synthesis by fungi. Advances in Microbial Physiology, 70, 105-121. https://doi.org/10.1016/bs.ampbs.2017.01.001

A wide range of fungicides (or antifungals) are used in agriculture and medicine, with activities against a spectrum of fungal pathogens. Unfortunately, the evolution of fungicide resistance has become a major issue. Therefore, there is an urgent nee... Read More about Metal-based combinations that target protein synthesis by fungi.

Temperate macroalgae impacts tropical fish recruitment at forefronts of range expansion (2017)
Journal Article
Beck, H., Feary, D. A., Nakamura, Y., & Booth, D. J. (in press). Temperate macroalgae impacts tropical fish recruitment at forefronts of range expansion. Coral Reefs, 36(2), https://doi.org/10.1007/s00338-017-1553-1

Warming waters and changing ocean currents are increasing the supply of tropical fish larvae to temperature regions where they are exposed to novel habitats, namely temperate macroalgae and barren reefs. Here, we use underwater surveys on the tempera... Read More about Temperate macroalgae impacts tropical fish recruitment at forefronts of range expansion.

Physiological roles of macrophages (2017)
Journal Article
Gordon, S., & Martinez-Pomares, L. (in press). Physiological roles of macrophages. Pflügers Archiv European Journal of Physiology, https://doi.org/10.1007/s00424-017-1945-7

Macrophages are present in mammals from midgestation, contributing to physiologic homeostasis throughout life. Macrophages arise from yolk sac and foetal liver progenitors during embryonic development in the mouse and persist in different organs as h... Read More about Physiological roles of macrophages.

Expression of Aspergillus niger CAZymes is determined by compositional changes in wheat straw generated by hydrothermal or ionic liquid pretreatments (2017)
Journal Article
Daly, P., van Munster, J. M., Blythe, M. J., Ibbett, R., Kokolski, M., Gaddipati, S., …Archer, D. B. (2017). Expression of Aspergillus niger CAZymes is determined by compositional changes in wheat straw generated by hydrothermal or ionic liquid pretreatments. Biotechnology for Biofuels, 10(1), Article 35. https://doi.org/10.1186/s13068-017-0700-9

Background The capacity of fungi, such as Aspergillus niger, to degrade lignocellulose is harnessed in biotechnology to generate biofuels and high-value compounds from renewable feedstocks. Most feedstocks are currently pretreated to increase enzy... Read More about Expression of Aspergillus niger CAZymes is determined by compositional changes in wheat straw generated by hydrothermal or ionic liquid pretreatments.

Bioprinting Using Mechanically Robust Core–Shell Cell-Laden Hydrogel Strands (2017)
Journal Article
Mistry, P., Aied, A., Alexander, M. R., Shakesheff, K., Bennett, A., & Yang, J. (2017). Bioprinting Using Mechanically Robust Core–Shell Cell-Laden Hydrogel Strands. Macromolecular Bioscience, 17(6), Article 1600472. https://doi.org/10.1002/mabi.201600472

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The strand material in extrusion-based bioprinting determines the microenvironments of the embedded cells and the initial mechanical properties of the constructs. One unmet challenge is the combinat... Read More about Bioprinting Using Mechanically Robust Core–Shell Cell-Laden Hydrogel Strands.