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Physiological roles of macrophages

Gordon, Siamon; Martinez-Pomares, Luisa

Authors

Siamon Gordon

Luisa Martinez-Pomares



Abstract

Macrophages are present in mammals from midgestation, contributing to physiologic homeostasis throughout life. Macrophages arise from yolk sac and foetal liver progenitors during embryonic development in the mouse and persist in different organs as heterogeneous, self-renewing tissue-resident populations. Bone marrow-derived blood monocytes are recruited after birth to replenish tissue-resident populations and to meet further demands during inflammation, infection and metabolic perturbations. Macrophages of mixed origin and different locations vary in replication and turnover, but are all active in mRNA and protein synthesis, fulfilling organ-specific and systemic trophic functions, in addition to host defence. In this review we emphasise selected properties and non-immune functions of tissue macrophages which contribute to physiologic homeostasis.

Journal Article Type Article
Journal Pflügers Archiv European Journal of Physiology
Print ISSN 0031-6768
Electronic ISSN 1432-2013
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
APA6 Citation Gordon, S., & Martinez-Pomares, L. (in press). Physiological roles of macrophages. Pflügers Archiv European Journal of Physiology, https://doi.org/10.1007/s00424-017-1945-7
DOI https://doi.org/10.1007/s00424-017-1945-7
Keywords Macrophages, Homeostasis, Tissue heterogeneity, Physiology, Receptors, Phagocytosis
Publisher URL http://link.springer.com/article/10.1007%2Fs00424-017-1945-7
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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