Physiological roles of macrophages

Gordon, Siamon; Martinez-Pomares, Luisa

Abstract

Macrophages are present in mammals from midgestation, contributing to physiologic homeostasis throughout life. Macrophages arise from yolk sac and foetal liver progenitors during embryonic development in the mouse and persist in different organs as heterogeneous, self-renewing tissue-resident populations. Bone marrow-derived blood monocytes are recruited after birth to replenish tissue-resident populations and to meet further demands during inflammation, infection and metabolic perturbations. Macrophages of mixed origin and different locations vary in replication and turnover, but are all active in mRNA and protein synthesis, fulfilling organ-specific and systemic trophic functions, in addition to host defence. In this review we emphasise selected properties and non-immune functions of tissue macrophages which contribute to physiologic homeostasis.

Citation

Gordon, S., & Martinez-Pomares, L. (in press). Physiological roles of macrophages. Pflügers Archiv European Journal of Physiology, https://doi.org/10.1007/s00424-017-1945-7

• Journal Article Type: Article
• Acceptance Date: Jan 27, 2017
• Online Publication Date: Feb 9, 2017
• Deposit Date: Feb 3, 2017
• Publicly Available Date: Feb 9, 2017
• Journal: Pflügers Archiv European Journal of Physiology
• Print ISSN: 0031-6768
• Electronic ISSN: 1432-2013
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1007/s00424-017-1945-7
• Keywords: Macrophages, Homeostasis, Tissue heterogeneity, Physiology, Receptors, Phagocytosis
• Public URL: https://nottingham-repository.worktribe.com/output/846663
• Publisher URL: http://link.springer.com/article/10.1007%2Fs00424-017-1945-7