All Outputs (474)

Histone deacetylase inhibition as an anticancer telomerase-targeting strategy (2011)
Journal Article

Aberrant epigenetic regulation of gene expression contributes to tumor initiation and progression. Studies from a plethora of hematologic and solid tumors support the use of histone deacetylase inhibitors (HDACi) as potent anticancer agents. The mech... Read More about Histone deacetylase inhibition as an anticancer telomerase-targeting strategy.

Evolutionary squeaky wheel optimization: a new framework for analysis (2011)
Journal Article

Squeaky wheel optimization (SWO) is a relatively new metaheuristic that has been shown to be effective for many real-world problems. At each iteration SWO does a complete construction of a solution starting from the empty assignment. Although the con... Read More about Evolutionary squeaky wheel optimization: a new framework for analysis.

Global Interventions for Seismic Upgrading of Substandard RC Buildings (2011)
Journal Article

A methodology is developed in this paper for the design and proportioning of interventions for seismic upgrading of substandard reinforced-concrete (RC) buildings. The retrofit approach is presented in the form of a simple design tool that aims towa... Read More about Global Interventions for Seismic Upgrading of Substandard RC Buildings.

Motor racing, tobacco company sponsorship, barcodes and alibi marketing (2011)
Journal Article

Abstract Background Sponsorship of Formula One (F1) motor racing, which has been used as an indirect medium of tobacco advertising for several decades, was prohibited by the 2005 European Union Tobacco Advertising Directive. Most F1 tobacco sponsors... Read More about Motor racing, tobacco company sponsorship, barcodes and alibi marketing.

Identification and recognition of depression in community care assessments: Impact of a national policy in England (2011)
Journal Article

Background: Depression continues to be under-recognized in older people. Most policies addressing this issue focus on the primary health care team. However, recognition may be improved by use of assessment tools and collaboration between secondary he... Read More about Identification and recognition of depression in community care assessments: Impact of a national policy in England.

Validation of Endogenous Control Genes for Gene Expression Studies on Human Ocular Surface Epithelium (2011)
Journal Article

Quantifying the effects of content, complexity and delay on memory for real-world images (2011)
Thesis

“A picture speaks a thousand words”, yet retrieval of a specific, previously viewed image from a large image collection may result in a substantial number of unwanted returns. This thesis offers an investigation into the feasibility of a novel soluti... Read More about Quantifying the effects of content, complexity and delay on memory for real-world images.

The benefits of quantifying climate model uncertainty in climate change impacts assessment: An example with heat-related mortality change estimates (2011)
Journal Article

The majority of climate change impacts assessments account for climate change uncertainty by adopting the scenario-based approach. This typically involves assessing the impacts for a small number of emissions scenarios but neglecting the role of clim... Read More about The benefits of quantifying climate model uncertainty in climate change impacts assessment: An example with heat-related mortality change estimates.

The genetics of pre-eclampsia and other hypertensive disorders of pregnancy (2011)
Journal Article

Hypertension is the most frequent medical complication occurring during pregnancy. In this chapter, we aim to address the genetic contribution to these disorders, with specific focus on preeclampsia. The pathogenic mechanisms underlying pre-eclampsia... Read More about The genetics of pre-eclampsia and other hypertensive disorders of pregnancy.

The collected letters of Robert Southey. Part two, 1798-1803 (2011)
Book

A "non-parametric" version of the naive Bayes classifier (2011)
Journal Article

Many algorithms have been proposed for the machine learning task of classication. One of the simplest methods, the naive Bayes classifyer, has often been found to give good performance despite the fact that its underlying assumptions (of independence... Read More about A "non-parametric" version of the naive Bayes classifier.

Dynamics of DNA replication in yeast (2011)
Journal Article

We present a mathematical model for the spatial dynamics of DNA replication. Using this model we determine the probability distribution for the time at which each chromosomal position is replicated. From this we show, contrary to previous reports, th... Read More about Dynamics of DNA replication in yeast.

Nonlinear summation really can be used to perform AND operations: reply to May and Zhaoping (2011)
Journal Article

From multipotent cells to fully differentiated connective tissue cells for regenerative medicine: emerging applications of mesenchymal stem cells (2011)
Book Chapter

Impulsivity and symptoms of nicotine dependence in a young adult population (2011)
Journal Article

Introduction: Impulsivity is widely regarded as a risk factor for drug dependence. However, its relationship with the symptomatology of nicotine dependence is poorly understood. Methods: To examine the nature of these relationships, we recru... Read More about Impulsivity and symptoms of nicotine dependence in a young adult population.

The importance of antioxidant micronutrients and vitamins in pregnancy (2011)
Journal Article

Pregnancy places increased demands on the mother to provide not only adequate nutrition to support her own health but also to enable the growth and development of the conceptus. A key role of a number of micronutrients and vitamins is their function... Read More about The importance of antioxidant micronutrients and vitamins in pregnancy.

Selenium in reproduction (2011)
Journal Article

Selenium is an essential trace element of importance to human biology and health. Increasing evidence suggests that this mineral plays an important role in normal growth and reproduction in animals and humans, and selenium supplementation is now reco... Read More about Selenium in reproduction.

“Frank Lloyd Oop”: microserfs, modern migration, and the architecture of the nineties (2011)
Journal Article

If the early development of the computing industry in America was marked by a preoccupation with hardware, as companies like UNIVAC, DEC, and IBM filled the nation’s corporate and government offices with mainframes, then a similar pre­occupation has... Read More about “Frank Lloyd Oop”: microserfs, modern migration, and the architecture of the nineties.

Abrasive wear behaviour of conventional and large-particle tungsten carbide-based cermet coatings as a function of abrasive size and type (2011)
Journal Article

Abrasive wear behaviour of materials can be assessed using a wide variety of testing methods, and the relative performance of materials will tend to depend upon the testing procedure employed. In this work, two cermet type coatings have been examined... Read More about Abrasive wear behaviour of conventional and large-particle tungsten carbide-based cermet coatings as a function of abrasive size and type.

Validation of a microsimulation of the port of Dover (2011)
Journal Article

Modelling and simulating the traffic of heavily used but secure environments such as seaports and airports is of increasing importance. Errors made when simulating these environments can have long standing economic, social and environmental implicati... Read More about Validation of a microsimulation of the port of Dover.