Histone deacetylase inhibition as an anticancer telomerase-targeting strategy

Rahman, Ruman; Grundy, Richard

Abstract

Aberrant epigenetic regulation of gene expression contributes to tumor initiation and progression. Studies from a plethora of hematologic and solid tumors support the use of histone deacetylase inhibitors (HDACi) as potent anticancer agents. The mechanism(s) of HDACi-induced cancer growth inhibition and cell death are complex and incompletely elucidated. Here, we discuss erroneous epigenetic regulation of hTERT transcription in cancer cells and propose that alleviation of an improper acetylation–deacetylation balance at the hTERT promoter, is one mode by which HDACi induces anticancer effects. We conclude with some pertinent questions and future perspectives arising from the recent impetus in HDACi preclinical and early clinical studies, with particular attention to the cancer stem cell therapeutic paradigm and its relevance to tumor resistance.

Citation

Rahman, R., & Grundy, R. (2011). Histone deacetylase inhibition as an anticancer telomerase-targeting strategy. International Journal of Cancer, 129(12), 2765-2774. doi:10.1002/ijc.26241

• Journal Article Type: Article
• Acceptance Date: May 30, 2011
• Online Publication Date: Aug 8, 2011
• Publication Date: Dec 15, 2011
• Deposit Date: Dec 5, 2018
• Journal: International Journal of Cancer
• Print ISSN: 0020-7136
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 129
• Issue: 12
• Pages: 2765-2774
• DOI: https://doi.org/10.1002/ijc.26241
• Keywords: Cancer Research; Oncology
• Public URL: https://nottingham-repository.worktribe.com/output/1370558
• Publisher URL: https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.26241