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Selenium in reproduction

Mistry, Hiten D.; Broughton Pipkin, Fiona; Redman, Christopher W.G.; Poston, Lucilla

Authors

Hiten D. Mistry

Fiona Broughton Pipkin

Christopher W.G. Redman

Lucilla Poston

Abstract

Selenium is an essential trace element of importance to human biology and health. Increasing evidence suggests that this mineral plays an important role in normal growth and reproduction in animals and humans, and selenium supplementation is now recommended as part of public health policy in geographical areas with severe selenium deficiency in soil. This review addresses the biological functions of selenium followed by a detailed review of associations between selenium status and reproductive health. In many countries, selenium dietary intake falls below the recommended nutrient intakes and is inadequate to support maximal expression of the selenoenzymes. Numerous reports implicate selenium deficiency in several reproductive and obstetric complications including male and female infertility, miscarriage, preeclampsia, fetal growth restriction, preterm labor, gestational diabetes, and obstetric cholestasis. Currently, there is inadequate information from the available small intervention studies to inform public health strategies. Larger intervention trials are required to reinforce or refute a beneficial role of selenium supplementation in disorders of reproductive health.

Journal Article Type Article
Publication Date Jan 1, 2012
Journal American Journal of Obstetrics and Gynecology
Print ISSN 0002-9378
Electronic ISSN 1097-6868
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 206
Issue 1
Institution Citation Mistry, H. D., Broughton Pipkin, F., Redman, C. W., & Poston, L. (2012). Selenium in reproduction. American Journal of Obstetrics and Gynecology, 206(1), doi:10.1016/j.ajog.2011.07.034
DOI https://doi.org/10.1016/j.ajog.2011.07.034
Publisher URL http://www.sciencedirect.com/science/article/pii/S0002937811009513?via%3Dihub
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf




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