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Selenium in reproduction

Mistry, Hiten D.; Broughton Pipkin, Fiona; Redman, Christopher W.G.; Poston, Lucilla

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Hiten D. Mistry

Fiona Broughton Pipkin

Christopher W.G. Redman

Lucilla Poston


Selenium is an essential trace element of importance to human biology and health. Increasing evidence suggests that this mineral plays an important role in normal growth and reproduction in animals and humans, and selenium supplementation is now recommended as part of public health policy in geographical areas with severe selenium deficiency in soil. This review addresses the biological functions of selenium followed by a detailed review of associations between selenium status and reproductive health. In many countries, selenium dietary intake falls below the recommended nutrient intakes and is inadequate to support maximal expression of the selenoenzymes. Numerous reports implicate selenium deficiency in several reproductive and obstetric complications including male and female infertility, miscarriage, preeclampsia, fetal growth restriction, preterm labor, gestational diabetes, and obstetric cholestasis. Currently, there is inadequate information from the available small intervention studies to inform public health strategies. Larger intervention trials are required to reinforce or refute a beneficial role of selenium supplementation in disorders of reproductive health.


Mistry, H. D., Broughton Pipkin, F., Redman, C. W., & Poston, L. (2012). Selenium in reproduction. American Journal of Obstetrics and Gynecology, 206(1),

Journal Article Type Article
Acceptance Date Jul 22, 2011
Online Publication Date Jul 29, 2011
Publication Date Jan 1, 2012
Deposit Date Jul 19, 2017
Publicly Available Date Jul 19, 2017
Journal American Journal of Obstetrics and Gynecology
Print ISSN 0002-9378
Electronic ISSN 1097-6868
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 206
Issue 1
Public URL
Publisher URL
Contract Date Jul 19, 2017


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