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Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells (2018)
Journal Article

Acute myeloid leukaemia (AML) cells often up-regulate pro-survival members of the BCL-2 protein family, such as BCL-2 and MCL-1, to avoid apoptosis. Venetoclax (ABT-199) targets BCL-2 and has shown promising efficacy in AML but over-expression of MCL... Read More about Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells.

On the real catalytically active species for CO2 fixation into cyclic carbonates under near ambient conditions: dissociation equilibrium of [BMIm][Fe(NO)2Cl2] dependant on reaction temperature (2018)
Journal Article

An imidazolium based iron-containing ionic liquid [BMIm][Fe(NO)2Cl2] (BMIm = 1-n-butyl-3-methyl-imidazolium) has been synthesized for the first time and fully characterized employing a wide range of techniques. The iron-based containing ionic liquid... Read More about On the real catalytically active species for CO2 fixation into cyclic carbonates under near ambient conditions: dissociation equilibrium of [BMIm][Fe(NO)2Cl2] dependant on reaction temperature.

Class 1 PI3K clinical candidates and recent inhibitor design strategies: a medicinal chemistry perspective (2018)
Journal Article

Phosphatidylinositol 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylate the 3-OH of the inositol ring of phosphoinositides, and deregulation of this pathway has implications in many diseases. The search for novel PI3K inhibitors has b... Read More about Class 1 PI3K clinical candidates and recent inhibitor design strategies: a medicinal chemistry perspective.

The professional development of counsellors and psychotherapists: Implications of empirical studies for supervision, training and practice (2018)
Journal Article

Background: This article presents key findings of two major empirical studies of psychotherapist and counsellor development. Both aimed to advance knowledge of variations in professional development and better understand the complexity of formative i... Read More about The professional development of counsellors and psychotherapists: Implications of empirical studies for supervision, training and practice.

A systematic review of behaviour change techniques within interventions to prevent return to smoking postpartum (2018)
Journal Article

Introduction: There is no routine support to prevent postpartum smoking relapse, due to lack of effective interventions. Previous reviews have identified behaviour change techniques (BCTs) within pregnancy cessation trials to specify which components... Read More about A systematic review of behaviour change techniques within interventions to prevent return to smoking postpartum.

In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft (2018)
Journal Article

The advent of innovative surgical procedures utilizing partial thickness corneal grafts has created a need for the development of synthetic implants to recreate corneal stromal tissue. This work evaluates electrospun gelatin and polycaprolactone (PCL... Read More about In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft.

A robust Bayesian methodology for damage localization in plate-like structures using ultrasonic guided-waves (2018)
Journal Article

SHM methods for damage detection and localization in plate-like structures have typically relied on signal post-processing techniques applied to ultrasonic guided-waves. The time of flight is one of these signals features which has been extensively u... Read More about A robust Bayesian methodology for damage localization in plate-like structures using ultrasonic guided-waves.