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Cell response to plasma electrolytic oxidation surface-modified low-modulus ?-type titanium alloys

Tanase, C.E.; Golozar, M.; Best, S.M.; Brooks, R.A.

Authors

C.E. Tanase

M. Golozar

S.M. Best

R.A. Brooks



Abstract

Plasma electrolytic oxidation (PEO) has been demonstrated to be an effective surface treatment for enhancing the osteoconduction and osseointegration of commercially pure ?-Ti (CP ?-Ti) dental implant materials for clinical application. To explore the feasibility of extending the application of PEO to low-modulus ?-type titanium alloys for load-bearing orthopaedic implants, a thorough understanding of the effect of substrate material on the biological performance of the PEO-treated surface is required. A 10?kW 50?Hz KeroniteTM processing unit was used to modify the surface of low-modulus near ?-Ti13Nb13Zr and ?-Ti45Nb substrates. CP ?-Ti and (??+??)-Ti6Al4V were also used in parallel as reference materials. In vitro culture of foetal human osteoblast (fHOb) cells on PEO-treated low-modulus near ?-Ti13Nb13Zr and ?-Ti45Nb alloys revealed comparable behaviour to that seen with CP ?-Ti and (??+??)-Ti6Al4V with respect to metabolic activity, collagen production, matrix formation and matrix mineralisation. No difference was observed in TNF-? and IL-10 cytokine release from CD14+ monocytes as markers of inflammatory response across samples. Cell interdigitation into the porous structure of the PEO coatings was demonstrated and cell processes remained adherent to the porous structure despite rigorous sonication. This study shows that PEO technology can be used to modify the surface of low-modulus ?-type titanium alloys with porous structure facilitating osseointegration, without impeding osteoblast activity or introducing an untoward inflammatory response.

Citation

Tanase, C., Golozar, M., Best, S., & Brooks, R. (2021). Cell response to plasma electrolytic oxidation surface-modified low-modulus ?-type titanium alloys. Colloids and Surfaces B: Biointerfaces, 176, 176-184. https://doi.org/10.1016/j.colsurfb.2018.12.064

Journal Article Type Article
Acceptance Date Dec 22, 2018
Online Publication Date Dec 26, 2018
Publication Date Apr 1, 2021
Deposit Date Mar 15, 2021
Journal Colloids and Surfaces B: Biointerfaces
Print ISSN 0927-7765
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 176
Pages 176-184
DOI https://doi.org/10.1016/j.colsurfb.2018.12.064
Keywords Biotechnology; Physical and Theoretical Chemistry; Colloid and Surface Chemistry; Surfaces and Interfaces; General Medicine
Public URL https://nottingham-repository.worktribe.com/output/3918965
Publisher URL https://www.sciencedirect.com/science/article/abs/pii/S0927776518309457
Additional Information This article is maintained by: Elsevier; Article Title: Cell response to plasma electrolytic oxidation surface-modified low-modulus β-type titanium alloys; Journal Title: Colloids and Surfaces B: Biointerfaces; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.colsurfb.2018.12.064; Content Type: article; Copyright: Crown Copyright © 2019 Published by Elsevier B.V. All rights reserved.