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Frequency difference mapping applied to the corpus callosum at 7T

Tendler, Benjamin C.; Bowtell, Richard


Benjamin C. Tendler


Purpose: Frequency difference mapping (FDM) is a phase processing technique which characterises the non-linear temporal evolution of the phase of gradient echo signals. Here, a novel FDM processing algorithm is introduced, which is shown to reveal information about white matter microstructure. Unlike some other phase processing techniques, the FDM algorithm presented here does not require the use of phase unwrapping or sophisticated image processing. It uses a series of scaled complex divisions to unwrap phase and remove background fields.

Methods: 10 healthy subjects underwent a series of single-slice, sagittal multi-echo gradient echo scans at 7T with the slice positioned at the mid-line. Phase data were processed with the novel FDM algorithm and the temporal evolution of the magnitude signal and frequency difference was examined in 5 regions of the corpus callosum (genu, anterior body, middle body, posterior body and splenium).

Results: Consistent frequency difference contrast relative to surrounding tissue was observed in all subjects in the corpus callosum, and in other white matter regions where the nerves fibres run perpendicular to

Journal Article Type Article
Publication Date 2019-05
Journal Magnetic Resonance in Medicine
Print ISSN 0740-3194
Electronic ISSN 1522-2594
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 81
Issue 5
Pages 3017-3031
APA6 Citation Tendler, B. C., & Bowtell, R. (2019). Frequency difference mapping applied to the corpus callosum at 7T. Magnetic Resonance in Medicine, 81(5), 3017-3031.
Keywords Radiology Nuclear Medicine and imaging
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