Test-retest reliability of the human connectome: An OPM-MEG study

Rier, Lukas; Michelmann, Sebastian; Ritz, Harrison; Shah, Vishal; Hill, Ryan M.; Osborne, James; Doyle, Cody; Holmes, Niall; Bowtell, Richard; Brookes, Matthew J.; Norman, Kenneth A.; Hasson, Uri; Cohen, Jonathan D.; Boto, Elena

Abstract

Magnetoencephalography with optically pumped magnetometers (OPM-MEG) offers a new way to record electrophysiological brain function, with significant advantages over conventional MEG, including adaptability to head shape/size, free movement during scanning, increased signal amplitude, and no reliance on cryogenics. However, OPM-MEG remains in its infancy, with significant questions to be answered regarding the optimal system design. Here, we present an open-source dataset acquired using a newly constructed OPM-MEG system with a triaxial sensor design, 168 channels, OPM-optimised magnetic shielding, and active background field control. We measure the test-retest reliability of the human connectome, which was computed using amplitude envelope correlation to measure whole-brain (parcellated) functional connectivity, in 10 individuals while they watch a 600 s move clip. Our results show high repeatability between experimental runs at the group level, with a correlation coefficient of 0.81 in the θ, 0.93 in α⁠, and 0.94 in β frequency ranges. At the individual subject level, we found marked differences between individuals, but high within-subject robustness (correlations of 0.56 ± 0.25, 0.72 ± 0.15, and 0.78 ± 0.13 in α⁠, θ, and β respectively). These results compare well to previous findings using conventional MEG and show that OPM-MEG is a viable way to robustly characterise connectivity.

Citation

Rier, L., Michelmann, S., Ritz, H., Shah, V., Hill, R. M., Osborne, J., Doyle, C., Holmes, N., Bowtell, R., Brookes, M. J., Norman, K. A., Hasson, U., Cohen, J. D., & Boto, E. (2023). Test-retest reliability of the human connectome: An OPM-MEG study. Imaging Neuroscience, 1, 1-20. https://doi.org/10.1162/imag_a_00020

• Journal Article Type: Article
• Acceptance Date: Sep 1, 2023
• Online Publication Date: Oct 9, 2023
• Publication Date: 2023
• Deposit Date: Oct 10, 2023
• Publicly Available Date: Oct 19, 2023
• Journal: Imaging Neuroscience
• Print ISSN: 2837-6056
• Electronic ISSN: 2837-6056
• Publisher: Massachusetts Institute of Technology Press
• Peer Reviewed: Peer Reviewed
• Volume: 1
• Pages: 1-20
• DOI: https://doi.org/10.1162/imag_a_00020
• Keywords: optically pumped magnetometers, magnetoencephalography, functional connectivity, reliability, OPM-MEG
• Public URL: https://nottingham-repository.worktribe.com/output/25673020
• Publisher URL: https://direct.mit.edu/imag/article/doi/10.1162/imag_a_00020/117508/Test-retest-reliability-of-the-human-connectome-An