Measurement of Frontal Midline Theta Oscillations using OPM-MEG

Rhodes, Natalie; Rea, Molly; Boto, Elena; Rier, Lukas; Shah, Vishal; Hill, Ryan M.; Osborne, James; Doyle, Cody; Holmes, Niall; Coleman, Sebastian C.; Mullinger, Karen; Bowtell, Richard; Brookes, Matthew J.

Abstract

Optically pumped magnetometers (OPMs) are an emerging lightweight and compact sensor that can measure magnetic fields generated by the human brain. OPMs enable construction of wearable magnetoencephalography (MEG) systems, which offer advantages over conventional instrumentation. However, when trying to measure signals at low frequency, higher levels of inherent sensor noise, magnetic interference and movement artefact introduce a significant challenge. Accurate characterisation of low frequency brain signals is important for neuroscientific, clinical, and paediatric MEG applications and consequently, demonstrating the viability of OPMs in this area is critical. Here, we undertake measurement of theta band (4–8 Hz) neural oscillations and contrast a newly developed 174 channel triaxial wearable OPM-MEG system with conventional (cryogenic-MEG) instrumentation. Our results show that visual steady state responses at 4 Hz, 6 Hz and 8 Hz can be recorded using OPM-MEG with a signal-to-noise ratio (SNR) that is not significantly different to conventional MEG. Moreover, we measure frontal midline theta oscillations during a 2-back working memory task, again demonstrating comparable SNR for both systems. We show that individual differences in both the amplitude and spatial signature of induced frontal-midline theta responses are maintained across systems. Finally, we show that our OPM-MEG results could not have been achieved without a triaxial sensor array, or the use of postprocessing techniques. Our results demonstrate the viability of OPMs for characterising theta oscillations and add weight to the argument that OPMs can replace cryogenic sensors as the fundamental building block of MEG systems.

Citation

Rhodes, N., Rea, M., Boto, E., Rier, L., Shah, V., Hill, R. M., Osborne, J., Doyle, C., Holmes, N., Coleman, S. C., Mullinger, K., Bowtell, R., & Brookes, M. J. (2023). Measurement of Frontal Midline Theta Oscillations using OPM-MEG. NeuroImage, 271, Article 120024. https://doi.org/10.1016/j.neuroimage.2023.120024

• Journal Article Type: Article
• Acceptance Date: Mar 11, 2023
• Online Publication Date: Mar 12, 2023
• Publication Date: May 1, 2023
• Deposit Date: May 9, 2023
• Publicly Available Date: May 12, 2023
• Journal: NeuroImage
• Print ISSN: 1053-8119
• Electronic ISSN: 1095-9572
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 271
• Article Number: 120024
• DOI: https://doi.org/10.1016/j.neuroimage.2023.120024
• Keywords: Magnetoencephalography; Optically pumped magnetometers; Working memory; Neural oscillations; Theta oscillations; Low frequency
• Public URL: https://nottingham-repository.worktribe.com/output/18529413
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S1053811923001702?via%3Dihub