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A methodology to identify consensus classes from clustering algorithms applied to immunohistochemical data from breast cancer patients (2010)
Journal Article
Soria, D., Garibaldi, J. M., Ambrogi, F., Green, A. R., Powe, D., Rakha, E., …Ellis, I. O. (2010). A methodology to identify consensus classes from clustering algorithms applied to immunohistochemical data from breast cancer patients. Computers in Biology and Medicine, 40(3), https://doi.org/10.1016/j.compbiomed.2010.01.003

Single clustering methods have often been used to elucidate clusters in high dimensional medical data, even though reliance on a single algorithm is known to be problematic. In this paper, we present a methodology to determine a set of ‘core classes’... Read More about A methodology to identify consensus classes from clustering algorithms applied to immunohistochemical data from breast cancer patients.

Carbon gold rush and carbon cowboys: a new chapter in green mythology? (2010)
Journal Article
Nerlich, B., & Koteyko, N. (2010). Carbon gold rush and carbon cowboys: a new chapter in green mythology?. Environmental Communication, 4(1), https://doi.org/10.1080/17524030903522389

Individual and collective efforts to mitigate climate change in the form of carbon offsetting and emissions trading schemes have recently become the focus of much media attention. In this paper we explore a subset of the UK national press coverage ce... Read More about Carbon gold rush and carbon cowboys: a new chapter in green mythology?.

Adaptivity and a posteriori error control for bifurcation problems II: Incompressible fluid flow in open systems with Z_2 symmetry (2010)
Journal Article
Cliffe, A., Hall, E., Houston, P., Phipps, E. T., & Salinger, A. G. Adaptivity and a posteriori error control for bifurcation problems II: Incompressible fluid flow in open systems with Z_2 symmetry. Manuscript submitted for publication

In this article we consider the a posteriori error estimation and adaptive mesh refinement of discontinuous Galerkin finite element approximations of the bifurcation problem associated with the steady incompressible Navier-Stokes equations. Particula... Read More about Adaptivity and a posteriori error control for bifurcation problems II: Incompressible fluid flow in open systems with Z_2 symmetry.

From carbon markets to carbon morality: creative compounds as framing devices in online discourses on climate change mitigation (2010)
Journal Article
Koteyko, N., Thelwall, M., & Nerlich, B. (2010). From carbon markets to carbon morality: creative compounds as framing devices in online discourses on climate change mitigation. Science Communication, 32(1), https://doi.org/10.1177/1075547009340421

Lexical combinations of at least two roots around "carbon" as the hub, such as "carbon finance" or "carbon footprint," have recently become ubiquitous in English-speaking science, politics, and mass media. They are part of a new language evolving aro... Read More about From carbon markets to carbon morality: creative compounds as framing devices in online discourses on climate change mitigation.

Pneumonia and influenza: specific considerations in care homes (2010)
Journal Article
Gordon, A., & Ewan, V. (2010). Pneumonia and influenza: specific considerations in care homes. Reviews in Clinical Gerontology, 20(1), 69-80. https://doi.org/10.1017/S0959259810000043

This review provides an update on current evidence surrounding epidemiology, treatment and prevention of lower respiratory tract infection, with special reference to pneumonia and influenza, in care home residents. The care home sector is growing an... Read More about Pneumonia and influenza: specific considerations in care homes.

Structure-Based Discovery of Novel Chemotypes for Adenosine A2A Receptor Antagonists (2010)
Journal Article
Katritch, V., Jaakola, V., Lane, J. R., Lin, J., Ijzerman, A. P., Yeager, M., …Abagyan, R. (2010). Structure-Based Discovery of Novel Chemotypes for Adenosine A2A Receptor Antagonists. Journal of Medicinal Chemistry, 53(4), 1799-1809. https://doi.org/10.1021/jm901647p

The recent progress in crystallography of G-protein coupled receptors opens an unprecedented venue for structure-based GPCR drug discovery. To test efficiency of the structure-based approach, we performed molecular docking and virtual ligand screenin... Read More about Structure-Based Discovery of Novel Chemotypes for Adenosine A2A Receptor Antagonists.

Are we teaching our students what they need to know about ageing? Results from the National Survey of Undergraduate Teaching in Ageing and Geriatric Medicine (2010)
Journal Article
Gordon, A., Blundell, A. G., Gladman, J. R., & Masud, T. (2010). Are we teaching our students what they need to know about ageing? Results from the National Survey of Undergraduate Teaching in Ageing and Geriatric Medicine. Age and Ageing, 29(3), https://doi.org/10.1093/ageing/afq011

Introduction - Learning about ageing and the appropriate management of older patients is important for all doctors. This survey set out to evaluate what medical undergraduates in the UK are taught about ageing and geriatric medicine and how this tea... Read More about Are we teaching our students what they need to know about ageing? Results from the National Survey of Undergraduate Teaching in Ageing and Geriatric Medicine.

Cerebral misery perfusion diagnosed using hypercapnic blood-oxygenation-level-dependent contrast functional magnetic resonance imaging: a case report (2010)
Journal Article
Gordon, A. L., Goode, S., D'Souza, O., Auer, D. P., & Munshi, S. K. (2010). Cerebral misery perfusion diagnosed using hypercapnic blood-oxygenation-level-dependent contrast functional magnetic resonance imaging: a case report. Journal of Medical Case Reports, 4(1), https://doi.org/10.1186/1752-1947-4-54

Introduction Cerebral misery perfusion represents a failure of cerebral autoregulation. It is animportant differential diagnosis in post-stroke patients presenting with collapses in the presence of haemodynamically significant cerebrovascular stenos... Read More about Cerebral misery perfusion diagnosed using hypercapnic blood-oxygenation-level-dependent contrast functional magnetic resonance imaging: a case report.

5-Carboxyfluorescein tagged N-phenylanthranilamide as a tracer reagent for fluorescence polarization: A robust method to screen MAPK pathway allosteric inhibitors (2010)
Journal Article
Rezvani, Z. N., Mayer, R. J., & Chan, W. C. (2010). 5-Carboxyfluorescein tagged N-phenylanthranilamide as a tracer reagent for fluorescence polarization: A robust method to screen MAPK pathway allosteric inhibitors. Chemical Communications, 46(12), 2043-2045. https://doi.org/10.1039/b925042e

Fluorescence polarization using Nα-(fluorescein-5- carbonyl)-Nε-(N-[2-fluoro-4-iodophenyl]-3,4- difluoroanthraniloyl)lysyl amide is capable of rapidly identifying inhibitor ligands that bind to an allosteric site in MEK1. © The Royal Society of Chemi... Read More about 5-Carboxyfluorescein tagged N-phenylanthranilamide as a tracer reagent for fluorescence polarization: A robust method to screen MAPK pathway allosteric inhibitors.

Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues (2010)
Journal Article
Jaakola, V., Lane, J. R., Lin, J. Y., Katritch, V., Ijzerman, A. P., & Stevens, R. C. (2010). Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues. Journal of Biological Chemistry, 285(17), 13032-13044. https://doi.org/10.1074/jbc.M109.096974

The crystal structure of the human A(2A) adenosine receptor bound to the A(2A) receptor-specific antagonist, ZM241385, was recently determined at 2.6-A resolution. Surprisingly, the antagonist binds in an extended conformation, perpendicular to the p... Read More about Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues.

Coping with infertility online: An examination of self-help mechanisms in an online infertility support group (2010)
Journal Article
Malik, S. H., & Coulson, N. S. (2010). Coping with infertility online: An examination of self-help mechanisms in an online infertility support group. Patient Education and Counseling, 81(2), 315-318. https://doi.org/10.1016/j.pec.2010.01.007

Objective: To examine communication within an online infertility support group. Methods: A content analysis of 3500 messages posted to infertility bulletin boards. Results: The most frequently used self-help mechanisms were support or empathy (45.5%)... Read More about Coping with infertility online: An examination of self-help mechanisms in an online infertility support group.

Depolarization induced suppression of excitation and the emergence of ultraslow rhythms in neural networks (2010)
Journal Article
Hlinka, J., Hlinka, J., & Coombes, S. (2010). Depolarization induced suppression of excitation and the emergence of ultraslow rhythms in neural networks. Physical Review Letters, 104(6), https://doi.org/10.1103/PhysRevLett.104.068101

Ultraslow fluctuations (0.01-0.1 Hz) are a feature of intrinsic brain activity of as yet unclear origin. We propose a candidate mechanism based on retrograde endocannabinoid signaling in a synaptically coupled network of excitatory neurons. This is k... Read More about Depolarization induced suppression of excitation and the emergence of ultraslow rhythms in neural networks.

Potential Energy Surfaces Fitted by Artificial Neural Networks (2010)
Journal Article
Handley, C. M., & Popelier, P. L. A. (2010). Potential Energy Surfaces Fitted by Artificial Neural Networks. Journal of Physical Chemistry A, 114(10), 3371-3383. https://doi.org/10.1021/jp9105585

Molecular mechanics is the tool of choice for the modeling of systems that are so large or complex that it is impractical or impossible to model them by ab initio methods. For this reason there is a need for accurate potentials that are able to quick... Read More about Potential Energy Surfaces Fitted by Artificial Neural Networks.

The effect of cooperative Jahn–Teller interactions on C60− anions (2010)
Journal Article
Moujaes, E. A., & Dunn, J. L. (2010). The effect of cooperative Jahn–Teller interactions on C60− anions. Journal of Physics: Condensed Matter, 22(8), https://doi.org/10.1088/0953-8984/22/8/085007

Singly charged buckminsterfullerene anions, C60−, are subject to a strong intramolecular T [circle times] h Jahn–Teller (JT) effect. When such ions interact with other C60− ions in a solid through a cooperative JT effect, they will be subject to an... Read More about The effect of cooperative Jahn–Teller interactions on C60− anions.

A new method for conditioning stochastic groundwater flow models in fractured media (2010)
Journal Article
Milne, A., Cliffe, A., Holton, D., Houston, P., Jackson, C. P., & Joyce, S. A new method for conditioning stochastic groundwater flow models in fractured media. Manuscript submitted for publication

Many geological formations consist of crystalline rocks that have very low matrix permeability but allow flow through an interconnected network of fractures. Understanding the flow of groundwater through such rocks is important in considering disposa... Read More about A new method for conditioning stochastic groundwater flow models in fractured media.

Normed algebras of differentiable functions on compact plane sets (2010)
Journal Article
Dales, H., & Feinstein, J. (2010). Normed algebras of differentiable functions on compact plane sets. Indian Journal of Pure and Applied Mathematics, 41(1), https://doi.org/10.1007/s13226-010-0005-1

We investigate the completeness and completions of the normed algebras (D(1)(X),∥•∥) for perfect, compact plane sets X. In particular, we construct a radially self-absorbing, compact plane set X such that the normed algebra (D(1)(X),∥•∥) is not compl... Read More about Normed algebras of differentiable functions on compact plane sets.

Press protest and publics: the agency of publics in newspaper campaigns (2010)
Journal Article
Birks, J. (2010). Press protest and publics: the agency of publics in newspaper campaigns. Discourse and Communication, 4(1), https://doi.org/10.1177/1750481309353285

Campaign advocacy is a common but rarely researched practice in British tabloid journalism. Newspaper campaigns give an account of ‘public opinion’ to politicians, make explicit claims to speak for ‘the public’ and authentically represent them, and... Read More about Press protest and publics: the agency of publics in newspaper campaigns.