J. Hlinka
Depolarization induced suppression of excitation and the emergence of ultraslow rhythms in neural networks
Hlinka, J.; Hlinka, Jaroslav; Coombes, S.
Authors
Jaroslav Hlinka
Professor STEPHEN COOMBES STEPHEN.COOMBES@NOTTINGHAM.AC.UK
Professor of Applied Mathematics
Abstract
Ultraslow fluctuations (0.01-0.1 Hz) are a feature of intrinsic brain activity of as yet unclear origin. We propose a candidate mechanism based on retrograde endocannabinoid signaling in a synaptically coupled network of excitatory neurons. This is known to cause depolarization-induced suppression of excitation (DISE), which we model phenomenologically. We construct emergent network oscillations in a globally coupled network and show that for strong synaptic coupling DISE can lead to a synchronized population burst at the frequencies of resting brain rhythms. © 2010 The American Physical Society.
Citation
Hlinka, J., Hlinka, J., & Coombes, S. (2010). Depolarization induced suppression of excitation and the emergence of ultraslow rhythms in neural networks. Physical Review Letters, 104(6), https://doi.org/10.1103/PhysRevLett.104.068101
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 12, 2009 |
Online Publication Date | Feb 8, 2010 |
Publication Date | Feb 8, 2010 |
Deposit Date | Jan 27, 2010 |
Publicly Available Date | Mar 29, 2024 |
Journal | Physical Review Letters |
Print ISSN | 0031-9007 |
Electronic ISSN | 1079-7114 |
Publisher | American Physical Society |
Peer Reviewed | Peer Reviewed |
Volume | 104 |
Issue | 6 |
DOI | https://doi.org/10.1103/PhysRevLett.104.068101 |
Keywords | Neural networks, Depolarization induced suppression of excitation, splay states, Morris-Lecar model, strong global coupling |
Public URL | https://nottingham-repository.worktribe.com/output/1012772 |
Publisher URL | https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.104.068101 |
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