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Depolarization induced suppression of excitation and the emergence of ultraslow rhythms in neural networks

Hlinka, J.; Hlinka, Jaroslav; Coombes, S.

Authors

J. Hlinka

Jaroslav Hlinka



Abstract

Ultraslow fluctuations (0.01-0.1 Hz) are a feature of intrinsic brain activity of as yet unclear origin. We propose a candidate mechanism based on retrograde endocannabinoid signaling in a synaptically coupled network of excitatory neurons. This is known to cause depolarization-induced suppression of excitation (DISE), which we model phenomenologically. We construct emergent network oscillations in a globally coupled network and show that for strong synaptic coupling DISE can lead to a synchronized population burst at the frequencies of resting brain rhythms. © 2010 The American Physical Society.

Citation

Hlinka, J., Hlinka, J., & Coombes, S. (2010). Depolarization induced suppression of excitation and the emergence of ultraslow rhythms in neural networks. Physical Review Letters, 104(6), https://doi.org/10.1103/PhysRevLett.104.068101

Journal Article Type Article
Acceptance Date Jun 12, 2009
Online Publication Date Feb 8, 2010
Publication Date Feb 8, 2010
Deposit Date Jan 27, 2010
Publicly Available Date Mar 29, 2024
Journal Physical Review Letters
Print ISSN 0031-9007
Electronic ISSN 1079-7114
Publisher American Physical Society
Peer Reviewed Peer Reviewed
Volume 104
Issue 6
DOI https://doi.org/10.1103/PhysRevLett.104.068101
Keywords Neural networks, Depolarization induced suppression of excitation, splay states, Morris-Lecar model, strong global coupling
Public URL https://nottingham-repository.worktribe.com/output/1012772
Publisher URL https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.104.068101

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