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Depolarization induced suppression of excitation and the emergence of ultraslow rhythms in neural networks

Hlinka, J.; Hlinka, Jaroslav; Coombes, S.

Authors

J. Hlinka

Jaroslav Hlinka msxjh1@nottingham.ac.uk



Abstract

Ultraslow fluctuations (0.01-0.1 Hz) are a feature of intrinsic brain activity of as yet unclear origin. We propose a candidate mechanism based on retrograde endocannabinoid signaling in a synaptically coupled network of excitatory neurons. This is known to cause depolarization-induced suppression of excitation (DISE), which we model phenomenologically. We construct emergent network oscillations in a globally coupled network and show that for strong synaptic coupling DISE can lead to a synchronized population burst at the frequencies of resting brain rhythms. © 2010 The American Physical Society.

Journal Article Type Article
Publication Date Feb 8, 2010
Journal Physical Review Letters
Print ISSN 0031-9007
Electronic ISSN 1079-7114
Publisher American Physical Society
Peer Reviewed Peer Reviewed
Volume 104
Issue 6
APA6 Citation Hlinka, J., Hlinka, J., & Coombes, S. (2010). Depolarization induced suppression of excitation and the emergence of ultraslow rhythms in neural networks. Physical Review Letters, 104(6), https://doi.org/10.1103/PhysRevLett.104.068101
DOI https://doi.org/10.1103/PhysRevLett.104.068101
Keywords Neural networks, Depolarization induced suppression of excitation, splay states, Morris-Lecar model, strong global coupling
Publisher URL https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.104.068101
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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