All Outputs (114)

Paramagnetic rims are a promising diagnostic imaging biomarker in multiple sclerosis (2022)
Journal Article

Background: White matter lesions (WMLs) on brain magnetic resonance imaging (MRI) in multiple sclerosis (MS) may contribute to misdiagnosis. In chronic active lesions, peripheral iron-laden macrophages appear as paramagnetic rim lesions (PRLs). Objec... Read More about Paramagnetic rims are a promising diagnostic imaging biomarker in multiple sclerosis.

The role of temporal coherence and temporal predictability in the build-up of auditory grouping (2022)
Journal Article

The cochlea decomposes sounds into separate frequency channels, from which the auditory brain must reconstruct the auditory scene. To do this the auditory system must make decisions about which frequency information should be grouped together, and wh... Read More about The role of temporal coherence and temporal predictability in the build-up of auditory grouping.

Audiological biomarkers of tinnitus in an older Portuguese population (2022)
Journal Article

Tinnitus is a phantom sound perceived in the absence of external acoustic stimulation. It is described in a variety of ways (e.g., buzzing, ringing, and roaring) and can be a single sound or a combination of different sounds. Our study evaluated asso... Read More about Audiological biomarkers of tinnitus in an older Portuguese population.

Effectiveness of bimodal auditory and electrical stimulation in patients with tinnitus: A feasibility study (2022)
Journal Article

Background: Tinnitus is a common symptom, affecting about 10–15% of the adult population. When input from the somatosensory system can influence and/or elicit tinnitus, this type of subjective tinnitus is called somatosensory tinnitus. Recently, a ne... Read More about Effectiveness of bimodal auditory and electrical stimulation in patients with tinnitus: A feasibility study.

Longitudinal clinical study of patients with iron rim lesions in multiple sclerosis (2022)
Journal Article

Background: Iron rims (IRs) surrounding white matter lesions (WMLs) are suggested to predict a more severe disease course. Only small longitudinal cohorts of patients with and without iron rim lesions (IRLs) have been reported so far. Objective: To a... Read More about Longitudinal clinical study of patients with iron rim lesions in multiple sclerosis.

Chronic postoperative pain after total knee arthroplasty: The potential contributions of synovitis, pain sensitization and pain catastrophizing—An explorative study (2022)
Journal Article

Background: A subset of osteoarthritis patients will experience chronic postoperative pain after total knee arthroplasty (TKA), but the source of pain is unclear. The aim of this exploratory study was to assess patients with and without postoperative... Read More about Chronic postoperative pain after total knee arthroplasty: The potential contributions of synovitis, pain sensitization and pain catastrophizing—An explorative study.

Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review (2022)
Journal Article

Importance: Cerebral small vessel disease (SVD) causes a quarter of strokes and is the most common pathology underlying vascular cognitive impairment and dementia. An important step to developing new treatments is better trial methodology. Disease me... Read More about Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review.

Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study (2022)
Journal Article

Background Hypoxaemia during general anaesthesia can cause harm. Apnoeic oxygenation extends safe apnoea time, reducing risk during airway management. We hypothesised that low-flow nasal oxygenation (LFNO) would extend safe apnoea time similarly to... Read More about Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study.

The role of CYP2C19 genotyping to guide antiplatelet therapy following ischemic stroke or transient ischemic attack (2022)
Journal Article

Introduction: Clopidogrel is an antiplatelet agent recommended for secondary prevention of ischemic stroke (IS) and transient ischemic attack (TIA). Conversion of clopidogrel to its active metabolite by hepatic cytochrome P450-2C19 (CYP2C19) is essen... Read More about The role of CYP2C19 genotyping to guide antiplatelet therapy following ischemic stroke or transient ischemic attack.

Opt-in HIV testing in construction workplaces: an exploration of its suitability, using the socioecological framework (2022)
Journal Article

Background: Late diagnosis of HIV remains a challenge, despite improved testing and treatment. Testing is often targeted at high-risk groups; workplace events might normalise testing and allow access to a wider population. The construction workforce... Read More about Opt-in HIV testing in construction workplaces: an exploration of its suitability, using the socioecological framework.

Evaluation of opt-in HIV testing in the construction workplace using the socioecological framework (2022)
Journal Article

Background Late diagnosis of HIV remains a challenge and the construction workforce has several risk factors for HIV. In the Test@Work programme, we delivered HIV tests embedded within a general health check to construction workers, with high uptake... Read More about Evaluation of opt-in HIV testing in the construction workplace using the socioecological framework.

Conversation success in one-to-one and group conversation: a group concept mapping study of adults with normal and impaired hearing (2022)
Journal Article

Objective: The concept of conversation success is undefined, although prior work has variously related it to accurate exchange of information, alignment between interlocutors, and good management of misunderstandings. This study aimed (1) to identify... Read More about Conversation success in one-to-one and group conversation: a group concept mapping study of adults with normal and impaired hearing.

Potential Diagnostic Applications of Multi-Delay Arterial Spin Labeling in Early Alzheimer’s Disease: The Chinese Imaging, Biomarkers, and Lifestyle Study (2022)
Journal Article

Background: Cerebral blood flow (CBF) alterations are involved in the onset and progression of Alzheimer’s disease (AD) and can be a potential biomarker. However, CBF measured by single-delay arterial spin labeling (ASL) for discrimination of mild co... Read More about Potential Diagnostic Applications of Multi-Delay Arterial Spin Labeling in Early Alzheimer’s Disease: The Chinese Imaging, Biomarkers, and Lifestyle Study.

Multiple sclerosis and the risk of infection: Association of British Neurologists consensus guideline (2022)
Journal Article

Infection in people with multiple sclerosis (MS) is of major concern, particularly for those receiving disease-modifying therapies. This article explores the risk of infection in people with MS and provides guidance - developed by Delphi consensus by... Read More about Multiple sclerosis and the risk of infection: Association of British Neurologists consensus guideline.

What factors are important to whom in what context, when adults are prescribed hearing aids for hearing loss? A realist review protocol (2022)
Journal Article

INTRODUCTION: Hearing aids are the gold standard treatment to help manage hearing loss. However, not everyone who needs them has them, and of those who do, a significant proportion of people do not use them at all, or use them infrequently. Despite l... Read More about What factors are important to whom in what context, when adults are prescribed hearing aids for hearing loss? A realist review protocol.

What factors are important to whom in what context, when adults are prescribed hearing aids for hearing loss? A realist review protocol (2022)
Journal Article

Introduction Hearing aids are the gold standard treatment to help manage hearing loss. However, not everyone who needs them has them, and of those who do, a significant proportion of people do not use them at all, or use them infrequently. Despite li... Read More about What factors are important to whom in what context, when adults are prescribed hearing aids for hearing loss? A realist review protocol.

Protein kinase C-β distinctly regulates blood-brain barrier-forming capacity of Brain Microvascular endothelial cells and outgrowth endothelial cells (2022)
Journal Article

Outgrowth endothelial cells (OECs) provide an endogenous repair mechanism and thus maintain endothelial barrier integrity. As inhibition of protein kinase C-β (PKC-β) activity has been shown to attenuate endothelial damage in various pathological con... Read More about Protein kinase C-β distinctly regulates blood-brain barrier-forming capacity of Brain Microvascular endothelial cells and outgrowth endothelial cells.

Vegetable oils composition affects the intestinal lymphatic transport and systemic bioavailability of co-administered lipophilic drug cannabidiol (2022)
Journal Article

Although natural sesame oil has been shown to facilitate the lymphatic delivery and oral bioavailability of the highly lipophilic drug cannabidiol (CBD), considerable variability remains an unresolved challenge. Vegetable oils differ substantially in... Read More about Vegetable oils composition affects the intestinal lymphatic transport and systemic bioavailability of co-administered lipophilic drug cannabidiol.

Decentralised clinical trials in multiple sclerosis research (2022)
Journal Article

Randomised controlled trials (RCTs) play an important role in multiple sclerosis (MS) research, ensuring that new interventions are safe and efficacious before their introduction into clinical practice. Trials have been evolving to improve the robust... Read More about Decentralised clinical trials in multiple sclerosis research.

Time Course for Benefit and Risk with Ticagrelor and Aspirin in Individuals with Acute Ischemic Stroke or Transient Ischemic Attack Who Carry CYP2C19 Loss-of-Function Alleles: A Secondary Analysis of the CHANCE-2 Randomized Clinical Trial (2022)
Journal Article

Importance: Dual antiplatelet therapy (DAPT) with ticagrelor and aspirin has been found to be effective for secondary prevention after minor ischemic stroke or transient ischemic attack (TIA) in individuals who carry CYP2C19 loss-of-function (LOF) al... Read More about Time Course for Benefit and Risk with Ticagrelor and Aspirin in Individuals with Acute Ischemic Stroke or Transient Ischemic Attack Who Carry CYP2C19 Loss-of-Function Alleles: A Secondary Analysis of the CHANCE-2 Randomized Clinical Trial.