Amjad I. Altokhis
Longitudinal clinical study of patients with iron rim lesions in multiple sclerosis
Altokhis, Amjad I.; Hibbert, Aimee M.; Allen, Christopher M.; Mougin, Olivier; Alotaibi, Abdulmajeed; Lim, Su Yin; Constantinescu, Cris S.; Abdel-Fahim, Rasha; Evangelou, Nikos
Authors
Aimee M. Hibbert
Christopher M. Allen
PhD OLIVIER MOUGIN OLIVIER.MOUGIN@NOTTINGHAM.AC.UK
Senior Research Fellow
Abdulmajeed Alotaibi
Su Yin Lim
Cris S. Constantinescu
Rasha Abdel-Fahim
NIKOS EVANGELOU Nikos.Evangelou@nottingham.ac.uk
Clinical Professor
Abstract
Background: Iron rims (IRs) surrounding white matter lesions (WMLs) are suggested to predict a more severe disease course. Only small longitudinal cohorts of patients with and without iron rim lesions (IRLs) have been reported so far. Objective: To assess whether the presence and number of IRLs in patients with clinically isolated syndrome (CIS) and multiple sclerosis (MS) are associated with long-term disability or progressive disease. Methods: Ninety-one CIS/MS patients were recruited between 2008 and 2013 and scanned with 7 T magnetic resonance imaging (MRI). Expanded Disability Status Scale (EDSS) was used to calculate Age-related Multiple Sclerosis Severity Score (ARMSS) at the time of scan and at the latest clinical follow-up after 9 years. WMLs were assessed for the presence of IRL using Susceptibility weighted imaging (SWI)-filtered phase images. Results: In all, 132 IRLs were detected in 42 patients (46%); 9% of WMLs had IRs; 54% of the cohort had no rims, 30% had 1–3 rims and 16% had ⩾4. Patients with IRL had a higher EDSS and ARMSS. Presence of IRL was also a predictor of long-term disability, especially in patients with ⩾4 IRLs. IRLs have a greater impact on disability compared to the WML number and volume. Conclusion: The presence and number of perilesional IR on MRI hold prognostic value for long-term clinical disability in MS.
Citation
Altokhis, A. I., Hibbert, A. M., Allen, C. M., Mougin, O., Alotaibi, A., Lim, S. Y., …Evangelou, N. (2022). Longitudinal clinical study of patients with iron rim lesions in multiple sclerosis. Multiple Sclerosis Journal, 28(14), 2202-2211. https://doi.org/10.1177/13524585221114750
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 30, 2022 |
Online Publication Date | Aug 24, 2022 |
Publication Date | 2022-12 |
Deposit Date | Jul 26, 2022 |
Publicly Available Date | Aug 24, 2022 |
Journal | Multiple Sclerosis Journal |
Print ISSN | 1352-4585 |
Electronic ISSN | 1477-0970 |
Publisher | SAGE Publications |
Peer Reviewed | Peer Reviewed |
Volume | 28 |
Issue | 14 |
Pages | 2202-2211 |
DOI | https://doi.org/10.1177/13524585221114750 |
Keywords | Neurology (clinical); Neurology |
Public URL | https://nottingham-repository.worktribe.com/output/9401879 |
Publisher URL | https://journals.sagepub.com/doi/full/10.1177/13524585221114750 |
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Longitudinal clinical study of patients with iron rim lesions in multiple sclerosis
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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