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Age-related differences in myeloarchitecture measured at 7 T

Carradus, Andrew J.; Mougin, Olivier; Hunt, Benjamin A.E.; Tewarie, Prejaas K.; Geades, Nicolas; Morris, Peter G.; Brookes, Matthew J.; Gowland, Penny A.; Madan, Christopher R.


Andrew J. Carradus

Benjamin A.E. Hunt

Prejaas K. Tewarie

Nicolas Geades

Peter G. Morris


We have used the magnetisation transfer (MT) MRI measure as a primary measure of myelination in both the grey matter (GM) of the 78 cortical automated anatomical labelling (AAL) regions of the brain, and the underlying white matter in each region, in a cohort of healthy adults (aged 19 to 62 years old). The results revealed a significant quadratic trend in myelination with age, with average global myelination peaking at 42.9 years old in grey matter, and at 41.7 years old in white matter. We also explored the possibility of using the Nuclear Overhauser Enhancement (NOE) effect, which is acquired in a similar method to MT, as an additional measure of myelination. We found that the MT and NOE signals were strongly correlated in the brain and that the NOE effects displayed similar (albeit weaker) parabolic trends with age. We also investigated differences in cortical thickness with age, and confirmed a previous result of a linear decline of 4.5±1.2μm/year.


Carradus, A. J., Mougin, O., Hunt, B. A., Tewarie, P. K., Geades, N., Morris, P. G., …Madan, C. R. (2020). Age-related differences in myeloarchitecture measured at 7 T. Neurobiology of Aging, 96, 246-254.

Journal Article Type Article
Acceptance Date Aug 10, 2020
Online Publication Date Aug 22, 2020
Publication Date 2020-12
Deposit Date Aug 22, 2020
Publicly Available Date Aug 23, 2021
Journal Neurobiology of Aging
Print ISSN 0197-4580
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 96
Pages 246-254
Keywords Developmental Biology; Ageing; General Neuroscience; Geriatrics and Gerontology; Clinical Neurology
Public URL
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