Age-related differences in myeloarchitecture measured at 7 T

Carradus, Andrew J.; Mougin, Olivier; Hunt, Benjamin A.E.; Tewarie, Prejaas K.; Geades, Nicolas; Morris, Peter G.; Brookes, Matthew J.; Gowland, Penny A.; Madan, Christopher R.

Abstract

We have used the magnetisation transfer (MT) MRI measure as a primary measure of myelination in both the grey matter (GM) of the 78 cortical automated anatomical labelling (AAL) regions of the brain, and the underlying white matter in each region, in a cohort of healthy adults (aged 19 to 62 years old). The results revealed a significant quadratic trend in myelination with age, with average global myelination peaking at 42.9 years old in grey matter, and at 41.7 years old in white matter. We also explored the possibility of using the Nuclear Overhauser Enhancement (NOE) effect, which is acquired in a similar method to MT, as an additional measure of myelination. We found that the MT and NOE signals were strongly correlated in the brain and that the NOE effects displayed similar (albeit weaker) parabolic trends with age. We also investigated differences in cortical thickness with age, and confirmed a previous result of a linear decline of 4.5±1.2μm/year.

Citation

Carradus, A. J., Mougin, O., Hunt, B. A., Tewarie, P. K., Geades, N., Morris, P. G., …Madan, C. R. (2020). Age-related differences in myeloarchitecture measured at 7 T. Neurobiology of Aging, 96, 246-254. https://doi.org/10.1016/j.neurobiolaging.2020.08.009

• Journal Article Type: Article
• Acceptance Date: Aug 10, 2020
• Online Publication Date: Aug 22, 2020
• Publication Date: 2020-12
• Deposit Date: Aug 22, 2020
• Publicly Available Date: Aug 23, 2021
• Journal: Neurobiology of Aging
• Print ISSN: 0197-4580
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 96
• Pages: 246-254
• DOI: https://doi.org/10.1016/j.neurobiolaging.2020.08.009
• Keywords: Developmental Biology; Ageing; General Neuroscience; Geriatrics and Gerontology; Clinical Neurology
• Public URL: https://nottingham-repository.worktribe.com/output/4847523
• Publisher URL: https://www.sciencedirect.com/science/article/abs/pii/S0197458020302657