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Vegetable oils composition affects the intestinal lymphatic transport and systemic bioavailability of co-administered lipophilic drug cannabidiol

Feng, Wanshan; Qin, Chaolong; Abdelrazig, Salah; Bai, Ziyu; Raji, Mekha; Darwish, Randa; Chu, YenJu; Ji, Liuhang; Gray, David A.; Stocks, Michael J.; Constantinescu, Cris S.; Barrett, David A.; Fischer, Peter M.; Gershkovich, Pavel

Vegetable oils composition affects the intestinal lymphatic transport and systemic bioavailability of co-administered lipophilic drug cannabidiol Thumbnail


Authors

Wanshan Feng

Chaolong Qin

Salah Abdelrazig

Ziyu Bai

Mekha Raji

Randa Darwish

YenJu Chu

Liuhang Ji

DAVID GRAY david.gray@nottingham.ac.uk
Professor of Applied Lipid Science

MICHAEL STOCKS MICHAEL.STOCKS@NOTTINGHAM.AC.UK
Professor of Medicinal Chemistry and Drug Discovery

Cris S. Constantinescu

David A. Barrett

Peter M. Fischer



Abstract

Although natural sesame oil has been shown to facilitate the lymphatic delivery and oral bioavailability of the highly lipophilic drug cannabidiol (CBD), considerable variability remains an unresolved challenge. Vegetable oils differ substantially in composition, which could lead to differences in promotion of intestinal lymphatic transport of lipophilic drugs. Therefore, the differences in composition of sesame, sunflower, peanut, soybean, olive and coconut oils and their corresponding role as vehicles in promoting CBD lymphatic targeting and bioavailability were investigated in this study. The comparative analysis suggests that the fatty acids profile of vegetable oils is overall similar to the fatty acids profile in the corresponding chylomicrons in rat lymph. However, arachidonic acid (C20:4), was introduced to chylomicrons from endogenous nondietary sources. Overall, fatty acid composition of natural vegetable oils vehicles affected the intestinal lymphatic transport and bioavailability of CBD following oral administration in this work. Olive oil led to the highest concentration of CBD in the lymphatic system and in the systemic circulation in comparison to the other natural vegetable oils following oral administration in rats.

Journal Article Type Article
Acceptance Date Jun 19, 2022
Online Publication Date Jun 23, 2022
Publication Date Aug 25, 2022
Deposit Date Jul 1, 2022
Publicly Available Date Jun 24, 2023
Journal International Journal of Pharmaceutics
Print ISSN 0378-5173
Electronic ISSN 1873-3476
Publisher Elsevier BV
Peer Reviewed Peer Reviewed
Volume 624
Article Number 121947
DOI https://doi.org/10.1016/j.ijpharm.2022.121947
Keywords Pharmaceutical Science
Public URL https://nottingham-repository.worktribe.com/output/8771179
Publisher URL https://www.sciencedirect.com/science/article/pii/S0378517322005026?via%3Dihub