All Outputs (1122)

Modifiable risk factors for poor health outcomes in multiple sclerosis: the urgent need for research to maximise smoking cessation success (2019)
Journal Article
Marck, C. H., das Nair, R., Grech, L., Borland, R., & Constantinescu, C. S. (2020). Modifiable risk factors for poor health outcomes in multiple sclerosis: the urgent need for research to maximise smoking cessation success. Multiple Sclerosis Journal, 26(3), 266-271. https://doi.org/10.1177/1352458519858730

Tobacco smoking is a well-established risk factor for multiple sclerosis (MS) onset, progression, and poor health outcomes in people with MS. Despite smoking being a modifiable risk factor, no research has been undertaken to understand how, or who is... Read More about Modifiable risk factors for poor health outcomes in multiple sclerosis: the urgent need for research to maximise smoking cessation success.

Management of primary pterygium with intra-lesional injection of 5 flurouracil and bevacizumab (Avastin) (2019)
Journal Article
Ghoz, N., Britton, J., Ross, A. R., Mohammed, I., Hogan, E., Said, D. G., & Dua, H. S. (2019). Management of primary pterygium with intra-lesional injection of 5 flurouracil and bevacizumab (Avastin). Eye, 33(11), 1776-1783. https://doi.org/10.1038/s41433-019-0493-0

Background To assess the efficacy of combined 5FU and Avastin injections in the treatment of primary pterygium Methods Sixteen eyes with primary pterygium received intralesional 5 fluorouracil and Avastin (2.5–5 mg) injections every 2 weeks... Read More about Management of primary pterygium with intra-lesional injection of 5 flurouracil and bevacizumab (Avastin).

Prediction of Stroke Risk by Detection of Hemorrhage in Carotid Plaques: Meta-Analysis of Individual Patient Data (2019)
Journal Article
Schindler, A., Schinner, R., Altaf, N., Hosseini, A. A., Simpson, R. J., Esposito-Bauer, L., …Saam, T. (2019). Prediction of Stroke Risk by Detection of Hemorrhage in Carotid Plaques: Meta-Analysis of Individual Patient Data. JACC: Cardiovascular Imaging, 13(2), 395-406. https://doi.org/10.1016/j.jcmg.2019.03.028

Objectives The goal of this study was to compare the risk of stroke between patients with carotid artery disease with and without the presence of intraplaque hemorrhage (IPH) on magnetic resonance imaging. Background IPH in carotid stenosis incr... Read More about Prediction of Stroke Risk by Detection of Hemorrhage in Carotid Plaques: Meta-Analysis of Individual Patient Data.

The effectiveness and safety of anti-fibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 3; peer review: 2 approved] (2019)
Journal Article
Ker, K., Prieto-Merino, D., Sprigg, N., Mahmood, A., Bath, P., Kang Law, Z., …Roberts, I. (2019). The effectiveness and safety of anti-fibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 3; peer review: 2 approved]. Wellcome Open Research, Article 120. https://doi.org/10.12688/wellcomeopenres.13262.3

Introduction: The Anti-fibrinolytics Trialists Collaboration aims to increase knowledge about the effectiveness and safety of anti-fibrinolytic treatment by conducting individual patient data (IPD) meta-analyses of randomised trials. This article pre... Read More about The effectiveness and safety of anti-fibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 3; peer review: 2 approved].

Distinct mechanisms govern recalibration to audio-visual discrepancies in remote and recent history (2019)
Journal Article
Watson, D. M., Akeroyd, M. A., Roach, N. W., & Webb, B. S. (2019). Distinct mechanisms govern recalibration to audio-visual discrepancies in remote and recent history. Scientific Reports, 9, Article 8513. https://doi.org/10.1038/s41598-019-44984-9

To maintain perceptual coherence, the brain corrects for discrepancies between the senses. If, for example, lights are consistently offset from sounds, representations of auditory space are remapped to reduce this error (spatial recalibration). While... Read More about Distinct mechanisms govern recalibration to audio-visual discrepancies in remote and recent history.

Outcome Assessment by Central Adjudicators Versus Site Investigators in Stroke Trials: A Systematic Review and Meta-Analysis (2019)
Journal Article
Godolphin, P. J., Bath, P. M., Algra, A., Berge, E., Brown, M. M., Chalmers, J., …on behalf of the Adjudicating Outcomes in Stroke Trials Collaboration*. (2019). Outcome Assessment by Central Adjudicators Versus Site Investigators in Stroke Trials: A Systematic Review and Meta-Analysis. Stroke, 50(8), 2187-2196. https://doi.org/10.1161/strokeaha.119.025019

© 2019 American Heart Association, Inc. Background and Purpose-In randomized stroke trials, central adjudication of a trial's primary outcome is regularly implemented. However, recent evidence questions the importance of central adjudication in rando... Read More about Outcome Assessment by Central Adjudicators Versus Site Investigators in Stroke Trials: A Systematic Review and Meta-Analysis.

Antiplatelet Therapy After Noncardioembolic Stroke: An Individual Patient Data Network Meta-Analysis (2019)
Journal Article
Greving, J. P., Diener, H., Reitsma, J., Bath, P., Csiba, L., Hacke, W., …Algra, A. (2019). Antiplatelet Therapy After Noncardioembolic Stroke: An Individual Patient Data Network Meta-Analysis. Stroke, 50(7), 1812-1818. https://doi.org/10.1161/strokeaha.118.024497

© 2019 American Heart Association, Inc. Background and Purpose-We assessed the efficacy and safety of antiplatelet agents after noncardioembolic stroke or transient ischemic attack and examined how these vary according to patients' demographic and cl... Read More about Antiplatelet Therapy After Noncardioembolic Stroke: An Individual Patient Data Network Meta-Analysis.

Diverticular disease (2019)
Journal Article
Humes, D., & Spiller, R. (2019). Diverticular disease. Medicine, 47(7), 424-427. https://doi.org/10.1016/j.mpmed.2019.04.005

© 2019 Colonic diverticula are formed by mucosal outpouching from the colonic wall. Their presence increases with increasing age with most, in Caucasian, being situated in the left colon. The aetiology of these outpouchings is not fully understood bu... Read More about Diverticular disease.

The effect of intravenous iron on erythropoiesis in older people with hip fracture (2019)
Journal Article
Moppett, I., Rowlands, M., Mannings, A., Marufu, T., Sahota, O., & Yeung, J. (2019). The effect of intravenous iron on erythropoiesis in older people with hip fracture. Age and Ageing, 48(5), 751–755. https://doi.org/10.1093/ageing/afz049

Background: Anaemia following hip fracture is common and associated with worse outcomes. Intravenous iron is a potential non-transfusion treatment for this anaemia and has been found to reduce transfusion rates in previous observational studies. Ther... Read More about The effect of intravenous iron on erythropoiesis in older people with hip fracture.

Micronutrient and amino acid losses during renal replacement therapy for acute kidney injury (2019)
Journal Article
Oh, W. C., Mafrici, B., Rigby, M., Harvey, D., Sharman, A., Allen, J. C., …Devonald, M. A. (2019). Micronutrient and amino acid losses during renal replacement therapy for acute kidney injury. Kidney International Reports, 4(8), 1094-1108. https://doi.org/10.1016/j.ekir.2019.05.001

© 2019 International Society of Nephrology Introduction: Malnutrition is common in patients with acute kidney injury (AKI), particularly in those requiring renal replacement therapy (RRT). Use of RRT removes metabolic waste products and toxins, but i... Read More about Micronutrient and amino acid losses during renal replacement therapy for acute kidney injury.

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial (2019)
Journal Article
Al-Shahi Salman, R., Minks, D. P., Mitra, D., Rodrigues, M. A., Bhatnagar, P., du Plessis, J. C., …Thomas, K. (2019). Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial. Lancet Neurology, 18(7), 643-652. https://doi.org/10.1016/s1474-4422%2819%2930184-x

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemor... Read More about Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial.

Effects of brain training on brain blood flow (The Cognition and Flow Study—CogFlowS): protocol for a feasibility randomised controlled trial of cognitive training in dementia (2019)
Journal Article
Beishon, L., Evley, R., Panerai, R. B., Subramaniam, H., Mukaetova-Ladinska, E., Robinson, T., & Haunton, V. (2019). Effects of brain training on brain blood flow (The Cognition and Flow Study—CogFlowS): protocol for a feasibility randomised controlled trial of cognitive training in dementia. BMJ Open, 9(5), https://doi.org/10.1136/bmjopen-2018-027817

© Author(s) (or their employer(s)) 2019. Introduction Cognitive training is an emerging non-pharmacological treatment to improve cognitive and physical function in mild cognitive impairment (MCI) and early Alzheimer's disease (AD). Abnormal brain blo... Read More about Effects of brain training on brain blood flow (The Cognition and Flow Study—CogFlowS): protocol for a feasibility randomised controlled trial of cognitive training in dementia.

Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial (2019)
Journal Article
Baigent, C., Lasserson, D., Sullivan, F., Carrie, J., Rojas, J., Amoils, S., …Thomas, K. (2019). Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial. Lancet, 393(10191), 2613-2623. https://doi.org/10.1016/s0140-6736%2819%2930840-2

Background Antiplatelet therapy reduces the risk of major vascular events for people with occlusive vascular disease, although it might increase the risk of intracranial haemorrhage. Patients surviving the commonest subtype of intracranial haemorrhag... Read More about Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial.

Corneal nerves in health and disease (2019)
Journal Article
Al Aqaba, M. A., Dhillon, V. K., Mohammed, I., Said, D. G., & Dua, H. S. (2019). Corneal nerves in health and disease. Progress in Retinal and Eye Research, 73, Article 100762. https://doi.org/10.1016/j.preteyeres.2019.05.003

The cornea is the most sensitive structure in the human body. Corneal nerves adapt to maintain transparency and contribute to corneal health by mediating tear secretion and protective reflexes and provide trophic support to epithelial and stromal cel... Read More about Corneal nerves in health and disease.

Relationship between neuromelanin and dopamine terminals within the Parkinson’s nigrostriatal system (2019)
Journal Article
Martín-Bastida, A., Lao-Kaim, N. P., Roussakis, A. A., Searle, G. E., Xing, Y., Gunn, R. N., …Piccini, P. (2019). Relationship between neuromelanin and dopamine terminals within the Parkinson’s nigrostriatal system. Brain, 142(7), 2023–2036. https://doi.org/10.1093/brain/awz120

© 2019 The Author(s). All rights reserved. Parkinson's disease is characterized by the progressive loss of pigmented dopaminergic neurons in the substantia nigra and associated striatal deafferentation. Neuromelanin content is thought to reflect the... Read More about Relationship between neuromelanin and dopamine terminals within the Parkinson’s nigrostriatal system.

How do we know that our patients have benefitted from our ENT/Audiological interventions?: presented at the Annual Meeting of ADANO 2016 in Berlin (2019)
Journal Article
Hall, D. A., Kitterick, P. T., Heffernan, E., Fackrell, K., Lucas, L., & Ferguson, M. (2019). How do we know that our patients have benefitted from our ENT/Audiological interventions?: presented at the Annual Meeting of ADANO 2016 in Berlin. Otology and Neurotology, 40(4), e474-e481. https://doi.org/10.1097/MAO.0000000000001937

This short review article gives an introduction to some of the fundamental concepts and challenges facing measurement in hearing healthcare practice and research. The impact of hearing loss almost always extends beyond the sensory impairment itself,... Read More about How do we know that our patients have benefitted from our ENT/Audiological interventions?: presented at the Annual Meeting of ADANO 2016 in Berlin.

Determining the sample size for future trials of hearing instruments for unilaterally deaf adults: an application of network meta-analysis (2019)
Journal Article
Gaunt, A. C., & Kitterick, P. T. (2019). Determining the sample size for future trials of hearing instruments for unilaterally deaf adults: an application of network meta-analysis. Otology and Neurotology, 40(4), e342–e348. https://doi.org/10.1097/MAO.0000000000002186

Objective: Previous trials have compared the efficacy of hearing instruments to no intervention in adults with single- sided deafness (SSD) or the relative efficacy of different instruments. Network meta-analysis (NMA) was used to refine estimates of... Read More about Determining the sample size for future trials of hearing instruments for unilaterally deaf adults: an application of network meta-analysis.

Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients (2019)
Journal Article
Damion, R. A., Knight, M. J., McGarry, B. L., Bosnell, R., Jezzard, P., Harston, G. W., …Kauppinen, R. A. (2019). Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients. Physics in Medicine and Biology, 64(9), Article 095016. https://doi.org/10.1088/1361-6560/ab1442

The apparent diffusion coefficient (ADC) of cerebral water, as measured by diffusion MRI, rapidly decreases in ischaemia, highlighting a lesion in acute stroke patients. The MRI T2 relaxation time changes in ischaemic brain such that T2 in ADC lesion... Read More about Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients.

Hearing impairment and daily-life fatigue: a qualitative study (2019)
Journal Article
Holman, J. A., Drummond, A., Hughes, S. E., & Naylor, G. (2019). Hearing impairment and daily-life fatigue: a qualitative study. International Journal of Audiology, 58(7), 408-416. https://doi.org/10.1080/14992027.2019.1597284

Objective: Hearing impairment is linked to increased fatigue, yet little is known about the real-world impact of this fatigue. This qualitative study investigated the experience of daily-life fatigue in people with a hearing impairment. Design: Ind... Read More about Hearing impairment and daily-life fatigue: a qualitative study.

Content validity and readability of patient-reported questionnaire instruments of hearing disability (2019)
Journal Article
Manchaiah, V., Granberg, S., Grover, V., Saunders, G., & Hall, D. (2019). Content validity and readability of patient-reported questionnaire instruments of hearing disability. International Journal of Audiology, 58(9), 565-575. https://doi.org/10.1080/14992027.2019.1602738

Objective: The current study evaluates the content validity (i.e., domains assessed) and readability levels of patient-reported questionnaire instruments using internationally recognized procedures and tools. Design: A review of the literature to... Read More about Content validity and readability of patient-reported questionnaire instruments of hearing disability.