Effects of brain training on brain blood flow (The Cognition and Flow Study—CogFlowS): protocol for a feasibility randomised controlled trial of cognitive training in dementia

Beishon, Lucy; Evley, Rachel; Panerai, Ronney B.; Subramaniam, Hari; Mukaetova-Ladinska, Elizabeta; Robinson, Thompson; Haunton, Victoria

Abstract

© Author(s) (or their employer(s)) 2019. Introduction Cognitive training is an emerging non-pharmacological treatment to improve cognitive and physical function in mild cognitive impairment (MCI) and early Alzheimer's disease (AD). Abnormal brain blood flow is a key process in the development of cognitive decline. However, no studies have explored the effects of cognitive training on brain blood flow in dementia. The primary aim of this study is to assess the feasibility for a large-scale, randomised controlled trial of cognitive training in healthy older adults (HC), MCI and early AD. Methods and analysis This study will recruit 60 participants, in three subgroups of 20 (MCI, HC, AD), from primary, secondary and community services. Participants will be randomised to a 12-week computerised cognitive training programme (five × 30 min sessions per week), or waiting-list control. Participants will undergo baseline and follow-up assessments of: mood, cognition, quality of life and activities of daily living. Cerebral blood flow will be measured at rest and during task activation (pretraining and post-training) by bilateral transcranial Doppler ultrasonography, alongside heart rate (3-lead ECG), end-tidal CO 2 (capnography) and beat-to-beat blood pressure (Finometer). Participants will be offered to join a focus group or semistructured interview to explore barriers and facilitators to cognitive training in patients with dementia. Qualitative data will be analysed using framework analysis, and data will be integrated using mixed methods matrices. Ethics and dissemination Bradford Leeds Research Ethics committee awarded a favourable opinion (18/YH/0396). Results of the study will be published in peer-reviewed journals, and presented at national and international conferences on ageing and dementia. Trials registration number NCT03656107; Pre-results.

Citation

Beishon, L., Evley, R., Panerai, R. B., Subramaniam, H., Mukaetova-Ladinska, E., Robinson, T., & Haunton, V. (2019). Effects of brain training on brain blood flow (The Cognition and Flow Study—CogFlowS): protocol for a feasibility randomised controlled trial of cognitive training in dementia. BMJ Open, 9(5), Article e027817. https://doi.org/10.1136/bmjopen-2018-027817

• Journal Article Type: Article
• Acceptance Date: Mar 29, 2019
• Online Publication Date: May 22, 2019
• Publication Date: 2019-05
• Deposit Date: Jun 6, 2019
• Publicly Available Date: Jun 6, 2019
• Journal: BMJ Open
• Electronic ISSN: 2044-6055
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 5
• Article Number: e027817
• DOI: https://doi.org/10.1136/bmjopen-2018-027817
• Keywords: General Medicine
• Public URL: https://nottingham-repository.worktribe.com/output/2149185
• Publisher URL: https://bmjopen.bmj.com/content/9/5/e027817
• Contract Date: Jun 6, 2019