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Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial

Baigent, Colin; Lasserson, Daniel; Sullivan, Frank; Carrie, Johanna; Rojas, Javier; Amoils, Shannon; Bamford, John; Armitage, Jane; Rinkel, Gabriel; Lowe, Gordon; Emberson, Jonathan; Innes, Karen; Dinsmore, Lynn; Drever, Jonathan; Williams, Carol; Perry, David; McGill, Connor; Buchanan, David; Walker, Allan; Hutchison, Aidan; Matthews, Christopher; Fraser, Ruth; McGrath, Aileen; Deary, Ann; Anderson, Rosemary; Walker, Pauli; Hansen, Christian; Parker, Richard; Rodriguez, Aryelly; Macleod, Malcolm; Gattringer, Thomas; Palmer, Jeb; Sakka, Eleni; Adil-Smith, Jennifer; Minks, David; Mitra, Dipayan; Bhatnagar, Priya; du Plessis, Johannes; Joshi, Yogish; Lerpiniere, Christine; O'Brien, Richard; Burgess, Seona; Mead, Gillian; Paulton, Ruth; Doubal, Fergus; McCormick, Katrina; Hunter, Neil; Taylor, Pat; Parakramawansha, Ruwan; Perry, Jack; Blair, Gordon; MacRaild, Allan; Parry-Jones, Adrian; Johnes, Mary; Lee, Stephanie; Shaw, Kelly Marie; Burger, Ilse; Punter, Martin; Ingham, Andrea; Perez, J...

Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial Thumbnail


Authors

Colin Baigent

Daniel Lasserson

Frank Sullivan

Johanna Carrie

Javier Rojas

Shannon Amoils

John Bamford

Jane Armitage

Gabriel Rinkel

Gordon Lowe

Jonathan Emberson

Karen Innes

Lynn Dinsmore

Jonathan Drever

Carol Williams

David Perry

Connor McGill

David Buchanan

Allan Walker

Aidan Hutchison

Christopher Matthews

Ruth Fraser

Aileen McGrath

Ann Deary

Rosemary Anderson

Pauli Walker

Christian Hansen

Richard Parker

Aryelly Rodriguez

Malcolm Macleod

Thomas Gattringer

Jeb Palmer

Eleni Sakka

Jennifer Adil-Smith

David Minks

Dipayan Mitra

Priya Bhatnagar

Johannes du Plessis

Yogish Joshi

Christine Lerpiniere

Richard O'Brien

Seona Burgess

Gillian Mead

Ruth Paulton

Fergus Doubal

Katrina McCormick

Neil Hunter

Pat Taylor

Ruwan Parakramawansha

Jack Perry

Gordon Blair

Allan MacRaild

Adrian Parry-Jones

Mary Johnes

Stephanie Lee

Kelly Marie Shaw

Ilse Burger

Martin Punter

Andrea Ingham

Jane Perez

Zin Naing

Jordi Morell

Tracy Marsden

Andrea Hall

Sally Marshall

Louise Harrison

Rowilson Jarapa

Edith Wood

Victoria O'Loughlin

David Cohen

Silvie Davies

Kelechi Njoku

Mushiya Mpelembue

Laura Burgess

Radim Licenik

Mmua Ngwako

Nabeela Nisar

Rangah Niranchanan

Tatjana Roganova

Rajaram Bathula

Joseph Devine

Anette David

Anne Oshodi

Fenglin Guo

Emmanuelle Owoyele

Varthi Sukdeo

Robert Ballantine

Mudhar Abbdul-saheb

Angela Chamberlain

Aberami Chandrakumar

Philip Poku

Kirsty Harkness

Catrin Blank

Emma Richards

Ali Ali

Faith Kibutu

Olesia Balitska

Kathryn Birchall

Pauline Bayliss

Clare Doyle

Kathy Stocks

Arshad Majis

Jo Howe

Christine Kamara

Luke Barron

Ahmad Maatouk

Ralf Lindert

Katy Dakin

Jessica Redgrave

Biju Bhaskaran

Isam Salih

Debs Kelly

Susan Szabo

Dawn Tomlin

Helen Bearne

Jean Buxton

Pauline Fitzell

Georgina Ayres

Afaq Saulat

Kathleen Horan

Joanne Garfield-Smith

Harbens Bhakri

Paul Guyler

Devesh Sinha

Thayalini Loganathan

Amber Siddiqui

Anwer Siddiqui

Lucy Coward

Swapna Kunhunny

Sharon Tysoe

Rajalakshmi Orath Prabakaran

Shyam Kelavkar

Sindhu Rashmi

David Ngo

Kheng Xiong Ng

Nisha Menon

Sweni Shah

Mark Barber

Derek Esson

Fiona Brodie

Talat Anjum

Mushtaq Wani

Manju Krishnan

Leanne Quinn

Jayne Spencer

Terry Jones

Helen Thompson-Jones

Lynne Dacey

Srikanth Chenna

Sharon Storton

Sarah Thomas

Teresa Beaty

Shelley Treadwell

Caroline Davies

Susan Tucker

Lynda Connor

Peter Slade

Glyn Gainard

Girish Muddegowda

Ranjan Sanyal

Alda Remegoso

Nenette Abano

Chelsea Causley

Racquel Carpio

Stephanie Stevens

Adrian Butler

Resti Varquez

Hayley Denic

Francis Alipio

Andrew Moores

Adrian Barry

Holly Maguire

Jeanette Grocott

Kay Finney

Sue Lyjko

Christine Roffe

Joanne Hiden

Phillip Ferdinand

Vera Cvoro

Khalil Ullah

Nicola Chapman

Mandy Couser

Susan Pound

Katrina McCormick

Sean Mcauley

Senthil Raghunathan

Faye Shelton

Margi Godfrey

Diane Havard

AMANDA BUCK AMANDA.BUCK@NOTTINGHAM.AC.UK
Senior Clinical Trial Co-Ordinator

Kailash Krishnan

Nicola Gilzeane

Jack Roffe

Judith Clarke

Katherine Whittamore

Saima Sheikh

NIKOLA SPRIGG nikola.sprigg@nottingham.ac.uk
Professor of Stroke Medicine

Rekha Keshvara

Carla Jordan

Benjamin Jackson

Gwendoline Wilkes

Jason Appleton

Zhe Law

Oliver Matias

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Mohammed Moqsith

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Richard Miller

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Nikki Gautam

Duncan Bailey

Kelly Amor

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Raj Shekhar

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Iman Ahmed

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Neetish Goorah

Angela Bell

Christine Kelly

Arun Singh

Jamie Walford

Benjamin Tomlinson

Farzana Patel

Stephen Duberley

Ingrid Kane

Chakravarthi Rajkumar

Jane Gaylard

Joanna Breeds

Nicola Gainsborough

Alexandra Pitt-Ford

Emma Barbon

Laura Latter

Philip Thompson

Simon Hervey

Shrivakumar Krishnamoorthy

Joseph Vassallo

Deborah Walter

Helen Cochrane

Meena Srinivasan

Robert Campbell

Denise Donaldson

Nichola Motherwell

Frances Hurford

Indranil Mukherjee

Antony Kenton

Sheila Nyabadza

Irene Martin

Benjamin Hunt

Hardi Hassan

Sarah O'Toole

Bander Dallol

Janet Putterill

Ratneshwari Jha

Rachel Gallifent

Puneet Kakar

Aparna Pusalkar

kelly Chan

Puneet Dangri

Hannah Beadle

Angela Cook

Karen Crabtree

Santhosh Subramonian

Peter Owusu-Agyei

Natalie Temple

Nicola Butterworth-Cowin

Suzanne Ragab

Kerstin Knops

Emma Jinks

Christine Dickson

Laura Gleave

Judith Dube

Jacqui Leggett

Tatiana Garcia

Sissy Ispoglou

Rachel Evans

Sandeep Ankolekar

Anne Hayes

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Bithi Rahman

Josette Milligan

Carol Graham

Josin Jose

Breffni Keegan

Mandy Doherty

Jim Kelly

Caroline Blair

Richard Dewar

James White

Kelly Thomas



Abstract

Background Antiplatelet therapy reduces the risk of major vascular events for people with occlusive vascular disease, although it might increase the risk of intracranial haemorrhage. Patients surviving the commonest subtype of intracranial haemorrhage, intracerebral haemorrhage, are at risk of both haemorrhagic and occlusive vascular events, but whether antiplatelet therapy can be used safely is unclear. We aimed to estimate the relative and absolute effects of antiplatelet therapy on recurrent intracerebral haemorrhage and whether this risk might exceed any reduction of occlusive vascular events.

Citation

Baigent, C., Lasserson, D., Sullivan, F., Carrie, J., Rojas, J., Amoils, S., …Thomas, K. (2019). Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial. Lancet, 393(10191), 2613-2623. https://doi.org/10.1016/s0140-6736%2819%2930840-2

Journal Article Type Article
Acceptance Date May 1, 2019
Online Publication Date May 22, 2019
Publication Date Jun 29, 2019
Deposit Date Jun 13, 2019
Publicly Available Date Jun 13, 2019
Journal The Lancet
Print ISSN 0140-6736
Electronic ISSN 1474-547X
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 393
Issue 10191
Pages 2613-2623
DOI https://doi.org/10.1016/s0140-6736%2819%2930840-2
Keywords General Medicine
Public URL https://nottingham-repository.worktribe.com/output/2153663
Publisher URL https://www.sciencedirect.com/science/article/pii/S0140673619308402
Additional Information Date of acceptance is estimated.

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