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All Outputs (817)

Profiling Humoral Immune Responses to Clostridium difficile-Specific Antigens by Protein Microarray Analysis (2015)
Journal Article
Negm, O. H., Hamed, M. R., Dilnot, E. M., Shone, C. C., Marszalowska, I., Lynch, M., …Monaghan, T. M. (2015). Profiling Humoral Immune Responses to Clostridium difficile-Specific Antigens by Protein Microarray Analysis. Clinical and Vaccine Immunology, 22(9), 1033-1039. https://doi.org/10.1128/CVI.00190-15

Clostridium difficile is an anaerobic, Gram-positive, and spore-forming bacterium that is the leading worldwide infective cause of hospital-acquired and antibiotic-associated diarrhea. Several studies have reported associations between humoral immuni... Read More about Profiling Humoral Immune Responses to Clostridium difficile-Specific Antigens by Protein Microarray Analysis.

Developing and testing an internal audit tool of the psychosocial work environment in the oil and gas industry (2015)
Journal Article
Bergh, L. I. V., Hinna, S., Leka, S., & Zwetsloot, G. I. (2016). Developing and testing an internal audit tool of the psychosocial work environment in the oil and gas industry. Safety Science, 88, https://doi.org/10.1016/j.ssci.2015.06.003

The objective of this paper is to present and discuss a pilot study for conducting internal psychosocial risk auditing in the oil and gas industry, focusing on offshore units. Psychosocial risk auditing is a proactive method for monitoring the status... Read More about Developing and testing an internal audit tool of the psychosocial work environment in the oil and gas industry.

Performance of methods for meta-analysis of diagnostic test accuracy with few studies or sparse data (2015)
Journal Article
Takwoingi, Y., Guo, B., Riley, R. D., & Deeks, J. J. (2015). Performance of methods for meta-analysis of diagnostic test accuracy with few studies or sparse data. Statistical Methods in Medical Research, https://doi.org/10.1177/0962280215592269

Hierarchical models such as the bivariate and hierarchical summary receiver operating characteristic (HSROC) models are recommended for meta-analysis of test accuracy studies. These models are challenging to fit when there are few studies and/or spar... Read More about Performance of methods for meta-analysis of diagnostic test accuracy with few studies or sparse data.

Consensus on Hearing Aid Candidature and Fitting for Mild Hearing Loss, With and Without Tinnitus: Delphi Review (2015)
Journal Article
Sereda, M., Hoare, D. J., Nicholson, R., Smith, S., & Hall, D. A. (2015). Consensus on Hearing Aid Candidature and Fitting for Mild Hearing Loss, With and Without Tinnitus: Delphi Review. Ear and Hearing, 36(4), 417-429. https://doi.org/10.1097/AUD.0000000000000140

Objectives: In many countries including the United Kingdom, hearing aids are a first line of audiologic intervention for many people with tinnitus and aidable hearing loss. Nevertheless, there is a lack of high quality evidence to support that the... Read More about Consensus on Hearing Aid Candidature and Fitting for Mild Hearing Loss, With and Without Tinnitus: Delphi Review.

Women’s experiences of using vaginal trainers (dilators) to treat vaginal penetration difficulties diagnosed as vaginismus: a qualitative interview study (2015)
Journal Article
Macey, K., Gregory, A., Nunns, D., & das Nair, R. (2015). Women’s experiences of using vaginal trainers (dilators) to treat vaginal penetration difficulties diagnosed as vaginismus: a qualitative interview study. BMC Women's Health, 15(1), Article 49. https://doi.org/10.1186/s12905-015-0201-6

Background Recent research has highlighted controversies in the conceptualisation, diagnosis and treatment of vaginismus. Vaginal trainers are currently the most widely used treatment. Critiques have highlighted concerns that the evidence-base of... Read More about Women’s experiences of using vaginal trainers (dilators) to treat vaginal penetration difficulties diagnosed as vaginismus: a qualitative interview study.

“Having diabetes shouldn’t stop them”: healthcare professionals’ perceptions of physical activity in children with Type 1 diabetes (2015)
Journal Article
Quirk, H., Blake, H., Dee, B., & Glazebrook, C. (2015). “Having diabetes shouldn’t stop them”: healthcare professionals’ perceptions of physical activity in children with Type 1 diabetes. BMC Pediatrics, 15(1), https://doi.org/10.1186/s12887-015-0389-5

Background Healthcare professionals (HCP) working with children who have Type 1 Diabetes Mellitus (T1DM) have an important role in advising about and supporting the control of blood glucose level in relation to physical activity. Regular physical... Read More about “Having diabetes shouldn’t stop them”: healthcare professionals’ perceptions of physical activity in children with Type 1 diabetes.

Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer (2015)
Journal Article
Zamberlan, F., Lesbats, C., Rogers, N. J., Krupa, J. L., Pavlovskaya, G. E., Thomas, N. R., …Meersmann, T. (2015). Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer. ChemPhysChem, 16(11), https://doi.org/10.1002/cphc.201500367

A new approach for hyperpolarized 129Xe molecular sensors is explored using paramagnetic relaxation agents that can be deactivated upon chemical or enzymatic reaction with an analyte. Cryptophane encapsulated 129Xe within the vicinity of the paramagn... Read More about Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer.

Symptoms into words: how medical patients talk about fatigue (2015)
Book Chapter
Standen, P., Ward, C. D., Saunders, L., & Beer, C. (2015). Symptoms into words: how medical patients talk about fatigue. In C. D. Ward (Ed.), Meanings of ME: interpersonal and social dimensions of chronic fatigue (67-85). Palgrave Macmillan. https://doi.org/10.1057/9781137467324_7

Fatigue, which is the central symptom of CFS/ME, is notoriously difficult to define. We describe an investigation in which we raise two questions. First, does the way people use fatigue-related language reflect distinctive patterns? Second, is there... Read More about Symptoms into words: how medical patients talk about fatigue.

Does release of antimicrobial agents from impregnated external ventricular drainage catheters affect the diagnosis of ventriculitis? (2015)
Journal Article
Bayston, R., Ashraf, W., & Ortori, C. (2015). Does release of antimicrobial agents from impregnated external ventricular drainage catheters affect the diagnosis of ventriculitis?. Journal of Neurosurgery, 124(2), https://doi.org/10.3171/2014.12.JNS141900

OBJECT Recently concern has arisen over the effect of released antimicrobial agents from antibiotic-impregnated external ventricular drainage (EVD) catheters on the reliability of CSF culture for diagnosis of ventriculitis. The authors designed a... Read More about Does release of antimicrobial agents from impregnated external ventricular drainage catheters affect the diagnosis of ventriculitis?.

Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation (2015)
Journal Article
Smith, J. G. W., Celiz, A. D., Smith, J. G., Patel, A. K., Hook, A. L., Rajamohan, D., …Alexander, M. R. (2015). Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation. Advanced Materials, 27(27), 4006-4012. https://doi.org/10.1002/adma.201501351

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial... Read More about Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation.

Reproducibility of Graph-Theoretic Brain Network Metrics: A Systematic Review (2015)
Journal Article
Welton, T., Kent, D., Auer, D. P., & Dineen, R. A. (2015). Reproducibility of Graph-Theoretic Brain Network Metrics: A Systematic Review. Brain Connectivity, 5(4), 193-202. https://doi.org/10.1089/brain.2014.0313

This systematic review aimed to assess the reproducibility of graph-theoretic brain network metrics. Primary research studies of test-retest reliability conducted on healthy human subjects were included that quantified test-retest reliability using e... Read More about Reproducibility of Graph-Theoretic Brain Network Metrics: A Systematic Review.

Auditory training can improve working memory, attention, and communication in adverse conditions for adults with hearing loss (2015)
Journal Article
Ferguson, M. A., & Henshaw, H. (2015). Auditory training can improve working memory, attention, and communication in adverse conditions for adults with hearing loss. Frontiers in Psychology, 6, Article 556. https://doi.org/10.3389/fpsyg.2015.00556

Auditory training (AT) helps compensate for degradation in the auditory signal. A series of three high-quality training studies are discussed, which include, (i) a randomized controlled trial (RCT) of phoneme discrimination in quiet that trained adul... Read More about Auditory training can improve working memory, attention, and communication in adverse conditions for adults with hearing loss.

Practical dyspnea assessment: relationship between the 0–10 numerical rating scale and the four-level categorical verbal descriptor scale of dyspnea intensity (2015)
Journal Article
Wysham, N. G., Miriovsky, B. J., Currow, D. C., Herndon, J. E., Samsa, G. P., Wilcock, A., & Abernethy, A. P. (in press). Practical dyspnea assessment: relationship between the 0–10 numerical rating scale and the four-level categorical verbal descriptor scale of dyspnea intensity. Journal of Pain and Symptom Management, 50(4), https://doi.org/10.1016/j.jpainsymman.2015.04.015

Context—Measurement of dyspnea is important for clinical care and research. Objectives—To characterize the relationship between the 0–10 Numerical Rating Scale (NRS) and four-level categorical Verbal Descriptor Scale (VDS) for dyspnea assessment. M... Read More about Practical dyspnea assessment: relationship between the 0–10 numerical rating scale and the four-level categorical verbal descriptor scale of dyspnea intensity.

TLR2 Stimulation Regulates the Balance between Regulatory T Cell and Th17 Function: A Novel Mechanism of Reduced Regulatory T Cell Function in Multiple Sclerosis (2015)
Journal Article
Nyirenda, M. H., Morandi, E., Vinkemeier, U., Constantin-Teodosiu, D., Drinkwater, S., Mee, M., …Gran, B. (2015). TLR2 Stimulation Regulates the Balance between Regulatory T Cell and Th17 Function: A Novel Mechanism of Reduced Regulatory T Cell Function in Multiple Sclerosis. Journal of Immunology, 194(12), 5761-5774. https://doi.org/10.4049/%E2%80%8Bjimmunol.1400472

CD4+CD25hi FOXP3+ regulatory T cells (Tregs) maintain tolerance to self-Ags. Their defective function is involved in the pathogenesis of multiple sclerosis (MS), an inflammatory demyelinating disease of the CNS. However, the mechanisms of such defect... Read More about TLR2 Stimulation Regulates the Balance between Regulatory T Cell and Th17 Function: A Novel Mechanism of Reduced Regulatory T Cell Function in Multiple Sclerosis.

Medical students’ personal experience of high-stakes failure: case studies using interpretative phenomenological analysis (2015)
Journal Article
Patel, R., Tarrant, C., Bonas, S., & Shaw, R. (2015). Medical students’ personal experience of high-stakes failure: case studies using interpretative phenomenological analysis. BMC Medical Education, 15(1), Article 86. https://doi.org/10.1186/s12909-015-0371-9

Background Failing a high-stakes assessment at medical school is a major event for those who go through the experience. Students who fail at medical school may be more likely to struggle in professional practice, therefore helping individuals overco... Read More about Medical students’ personal experience of high-stakes failure: case studies using interpretative phenomenological analysis.

Markers of progression in early-stage invasive breast cancer: a predictive immunohistochemical panel algorithm for distant recurrence risk stratification (2015)
Journal Article
Aleskandarany, M. A., Soria, D., Green, A. R., Nolan, C., Diez-Rodriguez, M., Ellis, I. O., & Rakha, E. A. (2015). Markers of progression in early-stage invasive breast cancer: a predictive immunohistochemical panel algorithm for distant recurrence risk stratification. Breast Cancer Research and Treatment, 151(2), 325-333. https://doi.org/10.1007/s10549-015-3406-3

Accurate distant metastasis (DM) prediction is critical for risk stratification and effective treatment decisions in breast cancer (BC). Many prognostic markers/models based on tissue marker studies are continually emerging using conventional statist... Read More about Markers of progression in early-stage invasive breast cancer: a predictive immunohistochemical panel algorithm for distant recurrence risk stratification.

Imposed rate and extent of weight loss in obese men and adaptive changes in resting and total energy expenditure (2015)
Journal Article
Siervo, M., Faber, P., Lara, J., Gibney, E. R., Milne, E., Ritz, P., …Johnstone, A. M. (2015). Imposed rate and extent of weight loss in obese men and adaptive changes in resting and total energy expenditure. Metabolism, 64(8), 896-904. https://doi.org/10.1016/j.metabol.2015.03.011

© 2015 Elsevier Inc. All rights reserved. Objectives. Weight loss (WL) is associated with a decrease in total and resting energy expenditure (EE). We aimed to investigate whether (1) diets with different rate and extent of WL determined different cha... Read More about Imposed rate and extent of weight loss in obese men and adaptive changes in resting and total energy expenditure.

Childbirth experience questionnaire: validating its use in the United Kingdom (2015)
Journal Article
Walker, K. F., Wilson, P., Bugg, G., Dencker, A., & Thornton, J. (2015). Childbirth experience questionnaire: validating its use in the United Kingdom. BMC Pregnancy and Childbirth, 15(86), https://doi.org/10.1186/s12884-015-0513-4

BACKGROUND: The Childbirth Experience Questionnaire (CEQ) was developed in Sweden in 2010 and validated in 920 primiparous women. It has not been validated in the United Kingdom (UK). Measuring the impact of an intervention on a woman's childbirth e... Read More about Childbirth experience questionnaire: validating its use in the United Kingdom.