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Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer

Zamberlan, Francesco; Lesbats, Clémentine; Rogers, Nicola J.; Krupa, James L.; Pavlovskaya, Galina E.; Thomas, Neil R.; Faas, Henryk; Meersmann, Thomas

Authors

Francesco Zamberlan

Clémentine Lesbats

Nicola J. Rogers

James L. Krupa

NEIL THOMAS neil.thomas@nottingham.ac.uk
Professor of Medicinal and Biological Chemistry

Henryk Faas henryk.faas@Nottingham.ac.uk



Abstract

A new approach for hyperpolarized 129Xe molecular sensors is explored using paramagnetic relaxation agents that can be deactivated upon chemical or enzymatic reaction with an analyte. Cryptophane encapsulated 129Xe within the vicinity of the paramagnetic center experiences fast relaxation that, through chemical exchange of xenon atoms between cage and solvent pool, causes accelerated hyperpolarized 129Xe signal decay in the dissolved phase. In this work, the relaxivity of GadoliniumIII-DOTA on 129Xe in the solvent was increased eightfold through tethering of the paramagnetic molecule to a cryptophane cage. This potent relaxation agent can be ‘turned off’ specifically for 129Xe through chemical reactions that spatially separate the GdIII centre from the attached cryptophane cage. Unlike 129Xe chemical shift based sensors, the new concept does not require high spectral resolution and may lead to a new generation of responsive contrast agents for molecular MRI.

Journal Article Type Article
Publication Date Jun 17, 2015
Journal ChemPhysChem
Print ISSN 1439-4235
Electronic ISSN 1439-7641
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 16
Issue 11
APA6 Citation Zamberlan, F., Lesbats, C., Rogers, N. J., Krupa, J. L., Pavlovskaya, G. E., Thomas, N. R., …Meersmann, T. (2015). Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer. ChemPhysChem, 16(11), doi:10.1002/cphc.201500367
DOI https://doi.org/10.1002/cphc.201500367
Keywords Hyperpolarized xenon biosensor • MRI contrast agent • cryptophane • HyperCEST • molecular imaging
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/cphc.201500367/abstract
Related Public URLs http://www.interscience.wiley.com/
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
Additional Information This is the pre-peer reviewed version of the following article: Zamberlan, F., Lesbats, C., Rogers, N. J., Krupa, J. L., Pavlovskaya, G. E., Thomas, N. R., Faas, H. M. and Meersmann, T. (2015), Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer. ChemPhysChem, 16: 2294–2298. doi:10.1002/cphc.201500367, which has been published in final form at http://onlinelibrary.wi...cphc.201500367/abstract

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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