Reproducibility of Graph-Theoretic Brain Network Metrics: A Systematic Review
Welton, Thomas; Kent, Daniel; Auer, Dorothee P.; Dineen, Robert A.
Dorothee P. Auer
ROBERT DINEEN email@example.com
Professor of Neuroradiology
This systematic review aimed to assess the reproducibility of graph-theoretic brain network metrics. Primary research studies of test-retest reliability conducted on healthy human subjects were included that quantified test-retest reliability using either the intraclass correlation coefficient (ICC) or the coefficient of variance. The MEDLINE, Web of Knowledge, Google Scholar, and OpenGrey databases were searched up to February 2014. Risk of bias was assessed with 10 criteria weighted toward methodological quality. Twenty-three studies were included in the review (n=499 subjects) and evaluated for various characteristics, including sample size (5–45), retest interval (1 year), acquisition method, and test-retest reliability scores. For at least one metric, ICCs reached the fair range (ICC 0.40–0.59) in one study, the good range (ICC 0.60–0.74) in five studies, and the excellent range (ICC>0.74) in 16 studies. Heterogeneity of methods prevented further quantitative analysis. Reproducibility was good overall. For the metrics having three or more ICCs reported for both functional and structural networks, six of seven were higher in structural networks, indicating that structural networks may be more reliable over time. The authors were also able to highlight and discuss a number of methodological factors affecting reproducibility.
Welton, T., Kent, D., Auer, D. P., & Dineen, R. A. (2015). Reproducibility of Graph-Theoretic Brain Network Metrics: A Systematic Review. Brain Connectivity, 5(4), 193-202. https://doi.org/10.1089/brain.2014.0313
|Journal Article Type||Article|
|Acceptance Date||Dec 1, 2014|
|Deposit Date||May 11, 2017|
|Publisher||Mary Ann Liebert|
|Peer Reviewed||Peer Reviewed|
This file is under embargo due to copyright reasons.
You might also like
Altered whole-brain connectivity in albinism
Aberrant visual pathway development in albinism: from retina to cortex