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Imposed rate and extent of weight loss in obese men and adaptive changes in resting and total energy expenditure

Siervo, Mario; Faber, Peter; Lara, Jose; Gibney, Eileen R.; Milne, Eric; Ritz, Patrick; Lobley, Gerald E.; Elia, Marinos; Stubbs, R. James; Johnstone, Alexandra M.

Authors

Mario Siervo

Peter Faber

Jose Lara

Eileen R. Gibney

Eric Milne

Patrick Ritz

Gerald E. Lobley

Marinos Elia

R. James Stubbs

Alexandra M. Johnstone



Abstract

© 2015 Elsevier Inc. All rights reserved. Objectives. Weight loss (WL) is associated with a decrease in total and resting energy expenditure (EE). We aimed to investigate whether (1) diets with different rate and extent of WL determined different changes in total and resting EE and if (2) they influenced the level of adaptive thermogenesis, defined as the decline in total or resting EE not accounted by changes in body composition. Methods. Three groups of six, obesemen participated in a total fast for 6 days to achieve a 5% WLand a very lowcalorie (VLCD, 2.5 MJ/day) for 3 weeks or a low calorie (LCD, 5.2 MJ/day) diet for 6 weeks to achieve a 10% WL. A four-component modelwas used to measure body composition. Indirect calorimetry was used to measure resting EE. Total EE was measured by doubly labelled water (VLCD, LCD) and 24-hour whole-body calorimetry (fasting). Results. VLCD and LCD showed a similar degree ofmetabolic adaptation for total EE (VLCD = - 6.2%; LCD = -6.8%). Metabolic adaptation for resting EE was greater in the LCD (-0.4 MJ/day, - 5.3%) compared to the VLCD (-0.1 MJ/day, -1.4%) group. Resting EE did not decrease after shortterm fasting and no evidence of adaptive thermogenesis (+0.4 MJ/day) was found after 5%WL. The rate ofWL was inversely associated with changes in resting EE (n = 30, r = 0.-42, p = 0.01). Conclusions. The rate of WL did not appear to influence the decline in total EE in obese men after 10% WL. Approximately 6% of this decline in total EE was explained by mechanisms of adaptive thermogenesis.

Citation

Siervo, M., Faber, P., Lara, J., Gibney, E. R., Milne, E., Ritz, P., …Johnstone, A. M. (2015). Imposed rate and extent of weight loss in obese men and adaptive changes in resting and total energy expenditure. Metabolism, 64(8), 896-904. https://doi.org/10.1016/j.metabol.2015.03.011

Journal Article Type Article
Acceptance Date Mar 17, 2015
Online Publication Date Apr 8, 2015
Publication Date 2015-08
Deposit Date Nov 20, 2019
Journal Metabolism
Print ISSN 0026-0495
Electronic ISSN 1532-8600
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 64
Issue 8
Pages 896-904
DOI https://doi.org/10.1016/j.metabol.2015.03.011
Keywords Obesity, Weight loss, Energy expenditure, Metabolic adaptation
Public URL https://nottingham-repository.worktribe.com/output/3344942
Publisher URL https://www.sciencedirect.com/science/article/pii/S0026049515001043?via%3Dihub
Additional Information This article is maintained by: Elsevier; Article Title: Imposed rate and extent of weight loss in obese men and adaptive changes in resting and total energy expenditure; Journal Title: Metabolism; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.metabol.2015.03.011; Content Type: article; Copyright: Copyright © 2015 Published by Elsevier Inc.