All Outputs (1390)

Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers (2021)
Journal Article

The MRE11–RAD50–NBS1 (MRN) complex is critical for genomic stability. Although germline mutations in MRN may increase breast cancer susceptibility, such mutations are extremely rare. Here, we have conducted a comprehensive clinicopathological study o... Read More about Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers.

Improving growth rates in preweaning calves on dairy farms: A randomized controlled trial (2021)
Journal Article

Previous research has identified key factors associated with improved average daily gain (ADG) in preweaning dairy calves and these factors have been combined to create a web app–based calf health plan (www.nottingham.ac.uk/herdhealthtoolkit). A rand... Read More about Improving growth rates in preweaning calves on dairy farms: A randomized controlled trial.

A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection (2021)
Journal Article

Fecal microbiota transplantation (FMT) is highly effective in recurrent Clostridioides difficile infection (CDI); increasing evidence supports FMT in severe or fulminant Clostridioides difficile infection (SFCDI). However, the multifactorial mechanis... Read More about A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection.

Synergy between Toxoplasma gondii type I Δ GRA17 immunotherapy and PD-L1 checkpoint inhibition triggers the regression of targeted and distal tumors (2021)
Journal Article

Background: In this study, we hypothesize that the ability of the protozoan Toxoplasma gondii to modulate immune response within the tumor might improve the therapeutic effect of immune checkpoint blockade. We examined the synergetic therapeutic acti... Read More about Synergy between Toxoplasma gondii type I Δ GRA17 immunotherapy and PD-L1 checkpoint inhibition triggers the regression of targeted and distal tumors.

Identification of the Genome Segments of Bluetongue Virus Type 26/Type 1 Reassortants Influencing Horizontal Transmission in a Mouse Model (2021)
Journal Article

Bluetongue virus serotypes 1 to 24 are transmitted primarily by infected Culicoides midges, in which they also replicate. However, “atypical” BTV serotypes (BTV‐25, ‐26, ‐27 and ‐28) have recently been identified that do not infect and replicate in a... Read More about Identification of the Genome Segments of Bluetongue Virus Type 26/Type 1 Reassortants Influencing Horizontal Transmission in a Mouse Model.

Systematic Analysis of Breed, Methodological, and Geographical Impact on Equine Sperm Progressive Motility (2021)
Journal Article

Over the past five decades, there has been increasing evidence to indicate global declines in human semen quality. Parallel adverse trends measured in male animals indicate a potential environmental aetiology. This study evaluated the progressive mot... Read More about Systematic Analysis of Breed, Methodological, and Geographical Impact on Equine Sperm Progressive Motility.

Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus (2021)
Journal Article

Four undescribed cucurbitacins, designated as petiolaticins A–D, and four known cucurbitacins were isolated from the bark and leaves of Elaeocarpus petiolatus (Jack) Wall. Their chemical structures were elucidated based on detailed analyses of the NM... Read More about Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus.

A scoping review of the current evidence on treatment and outcomes following synovial sepsis (2021)
Journal Article

Background Synovial sepsis is a frequent cause of morbidity and mortality in horses. Despite advances in diagnostics and treatments, persistent infection or chronic lameness can occur. Objectives To perform a scoping review to identify and evalu... Read More about A scoping review of the current evidence on treatment and outcomes following synovial sepsis.

Exercising D. melanogaster Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex (2021)
Journal Article

Ageing is a major risk factor for many of the most prevalent diseases, including neurode-generative diseases, cancer, and heart disease. As the global population continues to age, behavioural interventions that can promote healthy ageing will improve... Read More about Exercising D. melanogaster Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex.

Biosecurity and the ornamental fish trade: A stakeholder perspective in England (2021)
Journal Article

The freshwater and marine ornamental fish industry is a primary route of hazard introduction and emergence, including aquatic animal diseases and non-native species. Prevention measures are key to reducing the risk of hazard incursion and establishme... Read More about Biosecurity and the ornamental fish trade: A stakeholder perspective in England.

Genetics of Asthma: Insights From Genome Wide Association Studies (2021)
Book Chapter

Asthma is a heterogeneous respiratory disease that can be influenced by genetic and environmental factors leading to disease susceptibility and progression. Genome-wide association studies (GWAS) of asthma have yielded replicated findings and identif... Read More about Genetics of Asthma: Insights From Genome Wide Association Studies.

Pharmacokinetics of paracetamol in the Thoroughbred horse following an oral multi-dose administration (2021)
Journal Article

Paracetamol is a widely used, non-opioid analgesic and antipyretic drug. Scientific evidence suggests that it is an effective pain treatment in equine medicine. However, there is very little published information about the pharmacokinetics of the dru... Read More about Pharmacokinetics of paracetamol in the Thoroughbred horse following an oral multi-dose administration.

Comparative pathology of dog and human prostate cancer (2021)
Journal Article

Though relatively rare in dogs, prostate cancer (PCa) is the most common non-cutaneous cancer in men. Human and canine prostate glands share many functional, anatomical and physiological features. Due to these similarities, canine PCa has been propos... Read More about Comparative pathology of dog and human prostate cancer.

Does using an endotracheal tube or a supraglottic airway device result in better unassisted ventilation in rabbits? (2021)
Journal Article

Extracellular vesicles, tumor growth, and the metastatic process (2021)
Book Chapter

Extracellular vesicles (EVs) form an important part of cell-to-cell communication, with roles in both health and disease. Within the cancer setting, this heterogenous population of extracellular messengers can have both pro- and antitumorigenic prope... Read More about Extracellular vesicles, tumor growth, and the metastatic process.

Sequence and structure comparison of ATP synthase F0 subunits 6 and 8 in notothenioid fish (2021)
Journal Article

Mitochondrial changes such as tight coupling of the mitochondria have facilitated sustained oxygen and respiratory activity in haemoglobin-less icefish of the Channichthyidae family. We aimed to characterise features in the sequence and structure of... Read More about Sequence and structure comparison of ATP synthase F0 subunits 6 and 8 in notothenioid fish.

Stakeholder Perceptions of Disease Management for Dairy Calves: “It’s Just Little Things That Make Such a Big Difference” (2021)
Journal Article

Calf morbidity and mortality rates are often high in dairy herds, raising animal welfare concerns and negatively affecting farm economic efficiency and future performance. Disease prevention is critical to maintain calves in good health, but interven... Read More about Stakeholder Perceptions of Disease Management for Dairy Calves: “It’s Just Little Things That Make Such a Big Difference”.

Waterborne protozoan outbreaks: An update on the global, regional, and national prevalence from 2017 to 2020 and sources of contamination (2021)
Journal Article

The aim of this review is to identify the worldwide trend of waterborne protozoan outbreaks and how it varies between geographic regions during the period from 2017 to 2020. Data about waterborne protozoan outbreaks were gathered and stratified by co... Read More about Waterborne protozoan outbreaks: An update on the global, regional, and national prevalence from 2017 to 2020 and sources of contamination.

Recent Advances in Experimental Dendritic Cell Vaccines for Cancer (2021)
Journal Article

The development of immunotherapeutic methods for the treatment of oncological diseases have made it possible to improve the effectiveness of standard therapies. There was no breakthrough after first using of personalized therapeutic vaccines based on... Read More about Recent Advances in Experimental Dendritic Cell Vaccines for Cancer.

Assessment of proliferation in breast cancer: cell cycle or mitosis? An observational study (2021)
Journal Article

Background and aims: Proliferation is an important indicator of breast cancer (BC) prognosis, but is assessed using different approaches. Not all cells in the cell cycle are committed to division. This study aimed to characterise quantitative differe... Read More about Assessment of proliferation in breast cancer: cell cycle or mitosis? An observational study.