Pharmacokinetics of paracetamol in the Thoroughbred horse following an oral multi-dose administration

Pesko, Bogumila; Habershon-Butcher, Jocelyn; Muir, Tessa; Gray, Bob; Taylor, Polly; Fenwick, Susanna; Hincks, Pamela; Scarth, James; Paine, Stuart

Abstract

Paracetamol is a widely used, non-opioid analgesic and antipyretic drug. Scientific evidence suggests that it is an effective pain treatment in equine medicine. However, there is very little published information about the pharmacokinetics of the drug in the horse. The aim of the research was to determine the pharmacokinetics of paracetamol in equine plasma and urine to inform treatment of Thoroughbred racehorses. In this multi-dose study, paracetamol was administered orally at 20mg/kg to six Thoroughbred horses. Pre- and post-administration urine and plasma samples were collected and analysed using a quantitative liquid chromatography–tandem mass spectrometry (LC-MS/MS) method. Pharmacokinetic analysis of urine and plasma paracetamol clearance profiles was carried out, which enabled the calculation of possible screening limits (SL) that can regulate for a detection time of 120h. Additionally, an estimation of orthocetamol concentration levels in urine was carried out to investigate any underlying relationship between the para- and ortho-isomers as both were suspected to contribute to basal levels, possibly due to environmental feed sources.

Citation

Pesko, B., Habershon-Butcher, J., Muir, T., Gray, B., Taylor, P., Fenwick, S., Hincks, P., Scarth, J., & Paine, S. (2022). Pharmacokinetics of paracetamol in the Thoroughbred horse following an oral multi-dose administration. Journal of Veterinary Pharmacology and Therapeutics, 45(1), 54-62. https://doi.org/10.1111/jvp.13024

• Journal Article Type: Article
• Acceptance Date: Sep 27, 2021
• Online Publication Date: Oct 13, 2021
• Publication Date: Jan 1, 2022
• Deposit Date: Nov 25, 2021
• Publicly Available Date: Oct 14, 2022
• Journal: Journal of Veterinary Pharmacology and Therapeutics
• Print ISSN: 0140-7783
• Electronic ISSN: 1365-2885
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 45
• Issue: 1
• Pages: 54-62
• DOI: https://doi.org/10.1111/jvp.13024
• Keywords: General Veterinary; Pharmacology
• Public URL: https://nottingham-repository.worktribe.com/output/6788109
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1111/jvp.13024
• Additional Information: This is the peer reviewed version of the following article: Pesko, B., Habershon-Butcher, J., Muir, T., Gray, B., Taylor, P., Fenwick, S., Hincks, P., Scarth, J., & Paine, S. (2022). Pharmacokinetics of paracetamol in the Thoroughbred horse following an oral multi-dose administration. Journal of Veterinary Pharmacology and Therapeutics, 45, 54– 62. which has been published in final form at https://doi.org/10.1111/jvp.13024. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.