Plasma and urine pharmacokinetics of two formulations of dexamethasone in greyhound dogs

Morris, Tim; Paine, Stuart W.; Zahra, Paul; Li, Eric; Colgan, Sally; Karamatic, Steven

Abstract

Dexamethasone, formulated as sodium phosphate and as phenylpropionate combined with sodium phosphate, was administered subcutaneously to six greyhounds. Plasma and urine were collected for up to 240h and analysed with a limit of quantification (LOQ) of at least 100pg/ml for dexamethasone. Dexamethasone, formulated as sodium phosphate, terminal half-life was 10.4h in plasma and approximately 16h in urine, and at 96h, plasma hydrocortisone concentrations returned to background with dexamethasone levels around the LOQ. Dexamethasone, formulated as phenylpropionate combined with sodium phosphate, terminal half-life, was 25.6h in plasma and approximately 26h in urine, and at 96h, plasma hydrocortisone concentrations returned to background with dexamethasone levels in three of the six greyhounds around the LOQ. Critical assessment of the pharmacokinetic and pharmacodynamic data indicated how it might be utilized for medication control in racing greyhounds.

Citation

Morris, T., Paine, S. W., Zahra, P., Li, E., Colgan, S., & Karamatic, S. (2021). Plasma and urine pharmacokinetics of two formulations of dexamethasone in greyhound dogs. Journal of Veterinary Pharmacology and Therapeutics, 44(5), 689-695. https://doi.org/10.1111/jvp.12970

• Journal Article Type: Article
• Acceptance Date: Mar 7, 2021
• Online Publication Date: Mar 17, 2021
• Publication Date: Mar 17, 2021
• Deposit Date: Mar 31, 2021
• Publicly Available Date: Mar 31, 2021
• Journal: Journal of Veterinary Pharmacology and Therapeutics
• Print ISSN: 0140-7783
• Electronic ISSN: 1365-2885
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 44
• Issue: 5
• Pages: 689-695
• DOI: https://doi.org/10.1111/jvp.12970
• Keywords: Pharmacology; General Veterinary
• Public URL: https://nottingham-repository.worktribe.com/output/5403364
• Publisher URL: https://onlinelibrary.wiley.com/doi/full/10.1111/jvp.12970