PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1

Foxler, Daniel E.; James, Victoria; Shelton, Samuel J.; de A. Vallim, Thomas Q.; Shaw, Peter E.; Sharp, Tyson V.

doi:10.1016/j.febslet.2011.03.013

Extracellular vesicles, tumor growth, and the metastatic process (2021)
Book Chapter
Wesson, F., Brown, T. J., & James, V. (2022). Extracellular vesicles, tumor growth, and the metastatic process. In D. Heymann (Ed.), Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside (275-284). (3rd). Elsevier. https://doi.org/10.1016/B978-0-12-821666-8.00058-X

Extracellular vesicles (EVs) form an important part of cell-to-cell communication, with roles in both health and disease. Within the cancer setting, this heterogenous population of extracellular messengers can have both pro- and antitumorigenic prope... Read More about Extracellular vesicles, tumor growth, and the metastatic process.

Extracellular Vesicles and Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review (2021)
Working Paper
Gomez, N., James, V., Onion, D., & Fairclough, L. Extracellular Vesicles and Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review

Background: Chronic Obstructive Pulmonary Disease (COPD) is a common inflammatory disease of the airways characterized by irreversible airflow limitation, ranking the third highest cause of death worldwide. Extracellular vesicles (EVs) are important... Read More about Extracellular Vesicles and Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review.

The Role of Extracellular Vesicles in the Development of a Cancer Stem Cell Microenvironment Niche and Potential Therapeutic Targets: a systematic review (2021)
Journal Article
Brown, T. J., & James, V. (2021). The Role of Extracellular Vesicles in the Development of a Cancer Stem Cell Microenvironment Niche and Potential Therapeutic Targets: a systematic review. Cancers, 13(10), Article 2435. https://doi.org/10.3390/cancers13102435

Cancer stem cells (CSCs) have increasingly been shown to be a crucial element of heterogenous tumors. Although a relatively small component of the population, they increase the resistance to treatment and the likelihood of recurrence. In recent years... Read More about The Role of Extracellular Vesicles in the Development of a Cancer Stem Cell Microenvironment Niche and Potential Therapeutic Targets: a systematic review.

Storage stability and delivery potential of cytochalasin B induced membrane vesicles (2021)
Journal Article
Kletukhina, S. K., Neustroeva, O. A., Kurbangaleeva, S. V., Salafutdinov, I. I., Rogov, A. M., James, V., …Gomzikova, M. O. (2021). Storage stability and delivery potential of cytochalasin B induced membrane vesicles. Biotechnology Reports, 30, Article e00616. https://doi.org/10.1016/j.btre.2021.e00616

Cell-free therapies based on extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) are considered as a promising tool for stimulating regeneration and immunomodulation. The need to develop a practical approach for large-scale produc... Read More about Storage stability and delivery potential of cytochalasin B induced membrane vesicles.

Mitochondria donation by mesenchymal stem cells: current understanding and mitochondria transplantation strategies (2021)
Journal Article
Gomzikova, M., James, V., & Rizvanov, A. (2021). Mitochondria donation by mesenchymal stem cells: current understanding and mitochondria transplantation strategies. Frontiers in Cell and Developmental Biology, 9, Article 653322. https://doi.org/10.3389/fcell.2021.653322

The phenomenon of mitochondria donation is found in various tissues of humans and animals and is attracting increasing attention. To date, numerous studies have described the transfer of mitochondria from stem cells to injured cells, leading to incre... Read More about Mitochondria donation by mesenchymal stem cells: current understanding and mitochondria transplantation strategies.

Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity (2021)
Journal Article
Ogurcov, S., Shulman, I., Garanina, E., Sabirov, D., Baichurina, I., Kuznetcov, M., …Mukhamedshina, Y. (2021). Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity. Brain Sciences, 11(3), Article 322. https://doi.org/10.3390/brainsci11030322

Background: Despite considerable interest in the search for a spinal cord injury (SCI) therapy, there is a critical need to develop a panel of diagnostic biomarkers to determine injury severity. In this regard, there is a requirement for continuing r... Read More about Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity.

Cytochalasin B-Induced Membrane Vesicles from Human Mesenchymal Stem Cells Overexpressing IL2 Are Able to Stimulate CD8+ T-Killers to Kill Human Triple Negative Breast Cancer Cells (2021)
Journal Article
Chulpanova, D. S., Gilazieva, Z. E., Kletukhina, S. K., Aimaletdinov, A. M., Garanina, E. E., James, V., …Solovyeva, V. V. (2021). Cytochalasin B-Induced Membrane Vesicles from Human Mesenchymal Stem Cells Overexpressing IL2 Are Able to Stimulate CD8+ T-Killers to Kill Human Triple Negative Breast Cancer Cells. Biology, 10(2), Article 141. https://doi.org/10.3390/biology10020141

Interleukin 2 (IL2) was one of the first cytokines used for cancer treatment due to its ability to stimulate anti-cancer immunity. However, recombinant IL2-based therapy is associated with high systemic toxicity and activation of regulatory T-cells,... Read More about Cytochalasin B-Induced Membrane Vesicles from Human Mesenchymal Stem Cells Overexpressing IL2 Are Able to Stimulate CD8+ T-Killers to Kill Human Triple Negative Breast Cancer Cells.

Human Mesenchymal Stem Cells Overexpressing Interleukin 2 Can Suppress Proliferation of Neuroblastoma Cells in Co-Culture and Activate Mononuclear Cells In Vitro (2020)
Journal Article
Chulpanova, D. S., Solovyeva, V. V., James, V., Arkhipova, S. S., Gomzikova, M. O., Garanina, E. E., …Rizvanov, A. A. (2020). Human Mesenchymal Stem Cells Overexpressing Interleukin 2 Can Suppress Proliferation of Neuroblastoma Cells in Co-Culture and Activate Mononuclear Cells In Vitro. Bioengineering, 7(2), Article 59. https://doi.org/10.3390/bioengineering7020059

High-dose recombinant interleukin 2 (IL2) therapy has been shown to be successful in renal cell carcinoma and metastatic melanoma. However, systemic administration of high doses of IL2 can be toxic, causing capillary leakage syndrome and stimulating... Read More about Human Mesenchymal Stem Cells Overexpressing Interleukin 2 Can Suppress Proliferation of Neuroblastoma Cells in Co-Culture and Activate Mononuclear Cells In Vitro.

Mesenchymal Stem Cell Therapy for Spinal Cord Contusion: A Comparative Study on Small and Large Animal Models (2019)
Journal Article
Mukhamedshina, Y., Shulman, I., Ogurcov, S., Kostennikov, A., Zakirova, E., Akhmetzyanova, E., …Rizvanov, A. (2019). Mesenchymal Stem Cell Therapy for Spinal Cord Contusion: A Comparative Study on Small and Large Animal Models. Biomolecules, 9(12), Article 811. https://doi.org/10.3390/biom9120811

Here, we provide a first comparative study of the therapeutic potential of allogeneic mesenchymal stem cells derived from bone marrow (BM-MSCs), adipose tissue (AD-MSCs), and dental pulp (DP-MSCs) embedded in fibrin matrix, in small (rat) and large (... Read More about Mesenchymal Stem Cell Therapy for Spinal Cord Contusion: A Comparative Study on Small and Large Animal Models.

Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation (2019)
Journal Article
Gomzikova, M. O., James, V., & Rizvanov, A. A. (2019). Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation. Frontiers in Immunology, 10, https://doi.org/10.3389/fimmu.2019.02663

The immunosuppressive potential of mesenchymal stem cells has been extensively investigated in many studies in vivo and in vitro. In recent years, a variety preclinical and clinical studies have demonstrated that mesenchymal stem cells ameliorate imm... Read More about Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation.

Specific trophoblast transcripts transferred by extracellular vesicles affect gene expression in endometrial epithelial cells and may have a role in embryo-maternal crosstalk (2019)
Journal Article
Es-Haghi, M., Godakumara, K., Häling, A., Lättekivi, F., Lavrits, A., Viil, J., …Fazeli, A. (2019). Specific trophoblast transcripts transferred by extracellular vesicles affect gene expression in endometrial epithelial cells and may have a role in embryo-maternal crosstalk. Cell Communication and Signaling, 17(1), Article 146. https://doi.org/10.1186/s12964-019-0448-x

© 2019 The Author(s). Background: Successful establishment of pregnancy hinges on appropriate communication between the embryo and the uterus prior to implantation, but the nature of this communication remains poorly understood. Here, we tested the h... Read More about Specific trophoblast transcripts transferred by extracellular vesicles affect gene expression in endometrial epithelial cells and may have a role in embryo-maternal crosstalk.

Extracellular vesicles in the diagnosis and treatment of central nervous system diseases (2019)
Journal Article
Shaimardanova, A. A., Solovyeva, V. V., Chulpanova, D. S., James, V., Kitaeva, K. V., & Rizvanov, A. A. (2020). Extracellular vesicles in the diagnosis and treatment of central nervous system diseases. Neural Regeneration Research, 15(4), 586=596. https://doi.org/10.4103/1673-5374.266908

Extracellular vesicles, exosomes and microvesicles, play a fundamental role in the activity of the nervous system, participating in signal transmission between neurons and providing the interaction of central nervous system (CNS) with all body system... Read More about Extracellular vesicles in the diagnosis and treatment of central nervous system diseases.

Analysis of the interaction and proliferative activity of adenocarcinoma, peripheral blood mononuclear and mesenchymal stromal cells after co-cultivation in vitro (2019)
Journal Article
Kitaeva, K. V., Prudnikov, T. S., Gomzikova, M. O., Kletukhina, S. K., James, V., Rizvanov, A. A., & Solovyeva, V. V. (2019). Analysis of the interaction and proliferative activity of adenocarcinoma, peripheral blood mononuclear and mesenchymal stromal cells after co-cultivation in vitro. BioNanoScience, 9(2), 502-509. https://doi.org/10.1007/s12668-019-00625-z

The tumor microenvironment is a heterogeneous population of cells actively involved in the process of growth and development of a tumor. Research has demonstrated the interactions between the different populations of cells are critical for the format... Read More about Analysis of the interaction and proliferative activity of adenocarcinoma, peripheral blood mononuclear and mesenchymal stromal cells after co-cultivation in vitro.

Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders (2019)
Journal Article
Galieva, L. R., James, V., Mukhamedshina, Y. O., & Rizvanov, A. A. (2019). Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders. Frontiers in Neuroscience, 13, Article 163. https://doi.org/10.3389/fnins.2019.00163

The use of extracellular vesicles (EVs) as cell free therapy is a promising approach to stimulate tissue regeneration including that of the nervous system. EVs transfer bioactive proteins and lipids, RNA and microRNAs, which play a relevant role in E... Read More about Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders.

Therapeutic prospects of extracellular vesicles in cancer treatment (2018)
Journal Article
Chulpanoval, D. S., Kitaeva, K. V., James, V., Rizvanov, A. A., & Solovyeval, V. V. (2018). Therapeutic prospects of extracellular vesicles in cancer treatment. Frontiers in Immunology, 9, Article 1534. https://doi.org/10.3389/fimmu.2018.01534

Extracellular vesicles (EVs) are released by all cells within the tumor microenvironment, such as endothelial cells, tumor-associated fibroblasts, pericytes and immune system cells. The EVs carry the cargo of parental cells formed of proteins and nuc... Read More about Therapeutic prospects of extracellular vesicles in cancer treatment.

Application of mesenchymal stem cells for therapeutic agent delivery in anti-tumor treatment (2018)
Journal Article
Chulpanoval, D. S., Kitaeva, K. V., Tazetdinoval, L. G., James, V., Rizvanov, A. A., & Solovyeval, V. V. (2018). Application of mesenchymal stem cells for therapeutic agent delivery in anti-tumor treatment. Frontiers in Pharmacology, 9, Article 259. https://doi.org/10.3389/fphar.2018.00259

Mesenchymal stem cells (MSCs) are non-hematopoietic progenitor cells, which can be isolated from different types of tissues including bone marrow, adipose tissue, tooth pulp, and placenta/umbilical cord blood. There isolation from adult tissues circu... Read More about Application of mesenchymal stem cells for therapeutic agent delivery in anti-tumor treatment.

Regulation of vascular endothelial growth factor in prostate cancer (2015)
Journal Article
de Brot, S., Ntekim, A., Cardenas, R., James, V., Allegrucci, C., Heery, D. M., …Mongan, N. P. (2015). Regulation of vascular endothelial growth factor in prostate cancer. Endocrine-Related Cancer, 22(3), Article R107-R123. https://doi.org/10.1530/ERC-15-0123

Prostate cancer (PCa) is the most common malignancy affecting men in the western world. Although radical prostatectomy and radiation therapy can successfully treat PCa in the majority of patients, up to ?30% will experience local recurrence or metast... Read More about Regulation of vascular endothelial growth factor in prostate cancer.

Circulating microRNAs for the prediction of metastasis in breast cancer patients diagnosed with early stage disease (2015)
Journal Article
Inns, J., & James, V. (2015). Circulating microRNAs for the prediction of metastasis in breast cancer patients diagnosed with early stage disease. Breast, 24(4), 364-369. https://doi.org/10.1016/j.breast.2015.04.001

Breast cancer is the second most common malignancy diagnosed in women worldwide. The greatest cause of breast cancer mortality is development of metastasis. For many women metastasis is an early event in breast cancer which goes undetected until its... Read More about Circulating microRNAs for the prediction of metastasis in breast cancer patients diagnosed with early stage disease.

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity (2012)
Journal Article
Foxler, D. E., Bridge, K. S., James, V., Webb, T. M., Mee, M., Wong, S. C. K., …Sharp, T. V. (2012). The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. Nature Cell Biology, 14(2), 201-208. https://doi.org/10.1038/ncb2424

There are three prolyl hydroxylases (PHD1, 2 and 3) that regulate the hypoxia-inducible factors (HIFs), the master transcriptional regulators that respond to changes in intracellular O2 tension1,2. In high O2 tension (normoxia) the PHDs hydroxylate t... Read More about The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1 (2011)
Journal Article
Foxler, D. E., James, V., Shelton, S. J., de A. Vallim, T. Q., Shaw, P. E., & Sharp, T. V. (2011). PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1. FEBS Letters, 585(7), 1089-1096. https://doi.org/10.1016/j.febslet.2011.03.013

LIMD1 is a tumour suppressor gene (TSG) down regulated in ?80% of lung cancers with loss also demonstrated in breast and head and neck squamous cell carcinomas. LIMD1 is also a candidate TSG in childhood acute lymphoblastic leukaemia. Mechanistically... Read More about PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1.

All Outputs (46)